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New multi-cancer trial results require a dedicated review, beyond this selected agency explanation.","Current age-, risk- and jurisdiction-specific preventive-service schedules and evidence.","New multicancer-screening outcome trials, downstream harms, access and follow-up comparisons."]},{"article_id":"healthy-aging","title":"Healthy aging and longevity","words":978,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.4","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Frailty, disability-specific adaptations, falls, sensory loss, malnutrition and social-care access need dedicated coverage. Drug and supplement longevity claims require intervention-specific human outcome reviews.","Current sensory-care, medication, nutrition, environmental and social-support evidence for functional outcomes.","Independent replication and longer follow-up of selected cognitive and biological-aging findings."]},{"article_id":"seed-oils","title":"Seed oils","words":1317,"questions":15,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Oil-specific processing, repeated high-temperature frying, oxidation-product exposures and replacement foods need dedicated evidence reviews. This article does not independently appraise every oil or commercial preparation.","Oil-specific exposure measurements and long-term clinical comparisons of frying/reuse conditions remain unappraised; these precautions do not close that evidence gap."]},{"article_id":"ultra-processed-foods","title":"Ultra-processed foods","words":3168,"questions":22,"references":26,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How reliably do classifiers agree on mixed dishes and changing branded products?","How much do formulation, food structure, eating rate and dietary replacement explain observed outcomes?","Which long-term randomized comparisons can separate processing from nutritional composition?","Further controlled texture/energy-density comparisons, independent replication, long-term outcomes and review-overlap reconciliation remain necessary."]},{"article_id":"intermittent-fasting","title":"Intermittent fasting","words":952,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term clinical disease and mortality outcomes, schedule-specific adherence, nutritional adequacy and suitability for frail adults, adolescents, pregnancy and eating-disorder history need focused review.","Replication of human autophagic-flux findings and meaningful clinical outcomes; schedule-specific benefits cannot be inferred from a cellular assay."]},{"article_id":"cold-water-immersion","title":"Cold-water immersion","words":902,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Larger modern trials, women and diverse medical populations, open-water settings and regimen-specific adaptation effects need dedicated review. This page cannot establish an optimal plunge temperature, duration or personal suitability.","Independent replication, diverse participants, delayed-immersion schedules, clinically meaningful harms and water-setting comparisons remain incomplete."]},{"article_id":"microplastics","title":"Microplastics","words":1618,"questions":14,"references":17,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated independent appraisal of tissue-analytic methods, published corrections and critiques, exposure-response relationships and interventions that change clinical outcomes remains necessary. This page does not establish a safe dose or a validated detoxification protocol."]},{"article_id":"creatine","title":"Creatine","words":2261,"questions":16,"references":21,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false,"supplemental_depth1_checked_at":"2026-10-20"},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent re-analysis of the disputed cognition meta-analysis","Long-duration renal outcomes and condition-specific eligibility","Product-specific contamination and combined-ingredient safety","Direct muscle/water measurement, adequately blinded replication, full review-overlap mapping and functional outcomes remain necessary."]},{"article_id":"dietary-supplements","title":"Dietary supplements","words":1592,"questions":12,"references":14,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which product-specific claims have replicated effects on patient-important outcomes?","How do regulation, contamination and interaction evidence differ by product and country?"]},{"article_id":"processed-meat","title":"Processed meat","words":1298,"questions":12,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Product-specific processing and additives, dose-response absolute-risk examples, low intake and vulnerable-population nutrition require focused review. High-temperature cooking is related but not identical to the processed-meat category."]},{"article_id":"human-biology","title":"Human biology: cells, tissues, and organs","words":961,"questions":13,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["detailed feedback mechanisms for individual organ systems","specific genetic interactions and their effect sizes","clinical tests of particular wellness mechanisms","Cell-type exceptions, noncoding RNA, organ-system integration and specific genetic or cellular disorders."]},{"article_id":"social-connection","title":"Social connection and loneliness","words":966,"questions":14,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative trials of specific loneliness interventions","online versus in-person relationships in different populations","long-term effects of community-level programs","Specific support interventions, harmful relationships, community infrastructure and changes over time need fuller comparative and population-specific coverage."]},{"article_id":"habits-and-behavior-change","title":"Habits and behavior change","words":963,"questions":14,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative effectiveness of habit apps and coaching","habit formation in different clinical conditions","long-term adherence and unintended effects of intensive tracking","Condition-specific program trials, accessibility, long-term adherence and adverse effects of intensive tracking still need dedicated review."]},{"article_id":"hand-hygiene","title":"Hand hygiene","words":993,"questions":14,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative trials of particular handwashing products","specialized infection-control procedures","skin irritation and accommodations for frequent washing","Product-specific effectiveness and irritation, accommodations, organism-specific settings and healthcare sterilization procedures."]},{"article_id":"blood-pressure","title":"Blood pressure","words":1435,"questions":19,"references":14,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["absolute benefits and harms for specific treatment comparisons","pregnancy-specific diagnostic guidance","expanded international guideline comparisons","Cause-specific and orthostatic assessment, age/pregnancy contexts, absolute treatment benefits/harms and expanded international comparisons."]},{"article_id":"lung-health","title":"Lungs and breathing","words":809,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative treatment evidence for asthma and COPD","independent evidence reviews of breathwork techniques","individualized evaluation of persistent or acute breathing symptoms","Full lung-function technical appraisal, population-specific reference equations and condition-specific accuracy/outcome interpretation."]},{"article_id":"hormones-and-thyroid","title":"Hormones and thyroid health","words":944,"questions":13,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["other endocrine conditions beyond thyroid disease","comparisons of thyroid treatment strategies","independent appraisal of commercial hormone-testing panels","Condition-specific hormone patterns, full current nodule guidance, treatment comparisons and broader endocrine disorders."]},{"article_id":"digestion-and-microbiome","title":"Digestion and the gut microbiome","words":1100,"questions":14,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["independent assessment of commercial microbiome tests","specific probiotic comparisons and patient-important outcomes","condition-specific evaluation of gut-health diets and protocols"]},{"article_id":"kidney-health","title":"Kidneys and fluid balance","words":1052,"questions":13,"references":9,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["eGFR measurement accuracy and specific limitations in different body compositions","comparative disease-modifying treatment evidence","protein, potassium, phosphorus and fluid needs by kidney-disease stage"]},{"article_id":"allergy-and-autoimmunity","title":"Allergy and autoimmune disease","words":1283,"questions":15,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["diagnostic accuracy of particular allergy and autoimmune tests","condition-specific treatments and their benefits and harms","evaluation of commercial food-sensitivity tests and immune-boosting claims","Disease-specific immune mechanisms, current diagnostic performance, non-IgE allergy and current treatment comparisons."]},{"article_id":"anemia-and-blood","title":"Anemia and oxygen transport","words":850,"questions":13,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["ferritin interpretation in inflammation","condition-specific treatment comparisons and monitoring","inherited anemias and other blood disorders","Full anemia guideline appraisal, defined-population thresholds, cell morphology and cause-specific treatment/monitoring."]},{"article_id":"mental-health","title":"Mental health and finding support","words":1038,"questions":11,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["anxiety-treatment comparisons","eating disorders","country-specific crisis services and condition-specific recovery","Condition/population-specific comparative therapy benefits and harms, credential systems, access and long-term recovery outcomes."]},{"article_id":"bone-health","title":"Bone health and osteoporosis","words":844,"questions":14,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["absolute fracture benefits and harms of specific medicines","age- and risk-specific screening comparisons","independent trial synthesis of calcium or vitamin D supplementation","Cause-specific bone disease, scan/biochemical interpretation, absolute fracture benefits and treatment harms, and independent supplement-trial synthesis."]},{"article_id":"eye-health","title":"Eye health and vision","words":952,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["myopia-control interventions in children","cataract treatment comparisons","diabetic-retinopathy examination schedules","Disease-specific exam limitations, refractive correction comparisons, visual disability and defined-population prevention/treatment outcomes."]},{"article_id":"hearing-health","title":"Hearing and noise exposure","words":894,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["device-by-device comparisons","balance disorders","condition-specific tinnitus and hearing-loss treatment reviews","Mixed and central auditory problems, hearing in noise, defined-population device outcomes and current candidacy/rehabilitation guidance."]},{"article_id":"oral-health","title":"Oral health and tooth decay","words":845,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["dental procedure comparisons","fluoride exposure and age-specific product guidance","oral-systemic associations and causality","Root/pulp disorders, adult and child dental-care comparisons, material safety, dry-mouth causes and current prevention-policy differences."]},{"article_id":"vaccines-and-infections","title":"Vaccines and infection prevention","words":982,"questions":14,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current vaccine schedules by jurisdiction","product-specific absolute benefit and harm estimates","infection-specific testing and treatments","Current product-specific schedules, antibody-product eligibility, response/durability differences and absolute benefit/harms comparisons."]},{"article_id":"inherited-health-and-rare-disease","title":"Genetic conditions and inheritance","words":864,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["condition-by-condition rare-disease summaries","newborn and reproductive screening decisions","gene-specific treatment and counseling reviews","Tissue-specific test sensitivity, individual recurrence risk, rearrangement-specific reproductive outcomes and condition-specific counseling."]},{"article_id":"chronic-pain-and-fatigue","title":"ME/CFS, fatigue, and fibromyalgia","words":937,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["ME/CFS treatment-specific controlled evidence","fibromyalgia intervention comparisons","the full range of persistent-pain conditions","Condition-specific controlled treatment evidence, PEM-aware support, orthostatic assessment and harms; full fibromyalgia/ME/CFS comparative synthesis."]},{"article_id":"understanding-symptoms","title":"Symptoms and laboratory results","words":679,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["symptom-specific diagnostic pathways","test-specific sensitivity and specificity","interpretation of repeated tests and incidental imaging findings","Condition- and test-specific interpretation, including timing and the limits of a negative result."]},{"article_id":"contraception-and-fertility","title":"Family planning, contraception, and fertility","words":863,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["age- and condition-specific fertility evaluation","method-specific absolute effectiveness and adverse effects","assisted-reproduction comparisons and local access","Contemporary guideline changes, age-specific evaluation, absolute method effectiveness and harms, and assisted-reproduction comparisons need dedicated appraisal."]},{"article_id":"pregnancy-and-postpartum","title":"Pregnancy and postpartum care","words":1082,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["birth interventions and recovery comparisons","lactation and feeding-specific care","condition-specific prenatal screening and medication decisions","Dating accuracy in differing circumstances, condition/test-specific performance and procedural harms, current screening pathways and individual reproductive decisions."]},{"article_id":"child-health-development","title":"Early childhood health and development","words":909,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["growth assessment and common pediatric illnesses","feeding problems and individualized infant nutrition","developmental-condition-specific interventions","Complete age-specific communication assessment, hearing-screen accuracy and follow-up pathways, multilingual/sign-language development and intervention comparisons."]},{"article_id":"adolescent-health","title":"Adolescent health and development","words":1057,"questions":15,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["confidential youth care by jurisdiction","transition to adult services","condition-specific adolescent treatment and safety reviews","Condition-specific transition outcomes, support needs and local consent/confidentiality rules beyond this conceptual US example."]},{"article_id":"menstrual-health-and-menopause","title":"Menstrual health, perimenopause, and menopause","words":993,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["PCOS and premenstrual-disorder treatment comparisons","premature ovarian insufficiency","current individualized absolute HRT benefit and harm estimates","Full cycle-phase endocrine explanations, altered cycles, current POI treatment/follow-up and individualized surgical/hormone decisions."]},{"article_id":"prostate-health","title":"Prostate health","words":823,"questions":12,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current prostate-cancer screening recommendations by age and jurisdiction","condition-specific treatment effectiveness and harms","cancer diagnosis and active-surveillance decisions","Full trial methods, crossover, competing risks, absolute treatment harms, current risk-stratified surveillance and jurisdiction-specific screening guidance remain open."]},{"article_id":"sex-gender-and-health","title":"Sex, gender, and inclusive health","words":806,"questions":12,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative benefits and harms of specific gender-related treatments by age","organ-specific screening schedules and local access rules","intersex conditions and variation in clinical needs","Validation and privacy of specific instruments, population representation and intervention-specific evidence remain separate tasks."]},{"article_id":"disability-and-access","title":"Disability and access to health","words":916,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["condition-specific accommodations and neurodivergent needs","local benefits, rights, and complaint pathways","comparative performance, fitting, maintenance, and funding of individual assistive products","Person-specific accommodations, neurodivergent needs, accessibility audits, local legal/funding pathways and comparative intervention outcomes."]},{"article_id":"indoor-air-home-health","title":"Indoor air and home health","words":902,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["radon testing and mitigation procedures by jurisdiction","specific purifier-model comparisons and ozone-generating devices","building investigations, major mold remediation, and validated diagnosis of exposure-related illness","Indoor-sensor calibration and particle composition, jurisdiction-specific index algorithms and full exposure/outcome comparisons."]},{"article_id":"work-and-health","title":"Workplace hazards and prevention","words":820,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["industry-specific exposure limits and occupational diseases","comparative evidence for particular ergonomics and shift-scheduling interventions","local worker protections and occupational-health assessment pathways","Current sector/jurisdiction requirements, peak/impulse noise, complete dosimetry validation and intervention outcome comparisons."]},{"article_id":"heat-and-travel-health","title":"Heat and health","words":838,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative evidence for cooling methods across humidity and temperature conditions","condition-specific fluid and medication planning","destination-specific health risks are addressed separately in the travel-health article","Measurement/forecast uncertainty, exposure-specific adaptation and full comparisons of cooling and heat-prevention programs."]},{"article_id":"first-aid-emergencies","title":"Emergencies and first-aid literacy","words":1014,"questions":12,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["complete current CPR/AED and pediatric first-aid training","injury-specific procedures and severe allergic reactions","country-specific emergency and poison-center contacts","Complete age/situation-specific practical first-aid training, emergency treatment algorithms and local emergency/poison contacts."]},{"article_id":"wearables-and-self-tracking","title":"Wearables and home measurements","words":1083,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current product-by-product validation and software revisions","heart-rate variability, VO2max, body composition, and readiness-score methods","self-experiment design, data privacy, and whether tracking improves clinical outcomes","Device/software/population-specific accuracy and clinical benefit, with current authorization and policy scope checked separately."]},{"article_id":"genetic-testing","title":"Genetic and direct-to-consumer testing","words":1070,"questions":14,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["condition-specific indications and confirmation of consumer findings","polygenic-score calibration and outcomes of using particular scores in care","pharmacogenomics, variants of uncertain significance, and company-specific privacy practices","Current laboratory reporting/consent policies, gene-drug-specific evidence and actionability, ancestry representation, clinical utility and confirmation pathways."]},{"article_id":"medication-safety","title":"Medicines: benefits, risks, and interactions","words":949,"questions":12,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["individual drug interactions, dose adjustments, and deprescribing","pregnancy, breastfeeding, and pediatric medicine-specific evidence","adverse-effect frequency and comparative benefits for individual treatments","Product-specific current labels, monitoring standards, interactions and applicability in defined patient populations."]},{"article_id":"surgery-procedures-consent","title":"Procedures and informed consent","words":877,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["procedure-specific alternatives and absolute benefits and harms","individual anaesthetic risks and rehabilitation planning","decision capacity, pediatric consent, and jurisdiction-specific legal requirements","Procedure-specific absolute effects, current consent law, individual anaesthetic risks and complete comparison of decision-support tools remain open."]},{"article_id":"rehabilitation","title":"Rehabilitation and everyday function","words":959,"questions":15,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative evidence, dose, and pacing for condition-specific programs","assistive-product fitting and multidisciplinary care plans","long-term outcomes, fatigue management, and access barriers","Product-specific selection and harms, long-term follow-up, access barriers and condition-specific rehabilitation dosing remain open."]},{"article_id":"navigating-healthcare","title":"Navigating healthcare and appointments","words":1002,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["country-specific insurance, referrals, complaints, and patient-rights pathways","caregiver authority and cross-border record sharing","access to second opinions, waiting-list services, and urgent care alternatives","Decision-specific aid validation/currentness, comparative communication outcomes, local interpreter/navigation services and follow-up failures."]},{"article_id":"social-determinants-health","title":"Social conditions and health equity","words":922,"questions":12,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current comparative evaluations of housing, income, food-access, and education interventions","structural discrimination and community-specific experiences","local resources, costs, eligibility, and implementation tradeoffs","Causal policy evaluations, group/community-specific experiences, intervention implementation, health-literacy measurement and comparative outcomes."]},{"article_id":"sexual-health","title":"Sexual health and wellbeing","words":896,"questions":12,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["infection-specific screening intervals, treatment, vaccination, and post-exposure prevention","sexual desire, erection or orgasm difficulties, and causes of sexual pain beyond vaginitis","consent education, violence support, and local confidential services","Current infection/population-specific testing and prevention schedules, updated PEP/PrEP regimens, confidentiality/access and full benefit/harms comparisons."]},{"article_id":"food-and-water-safety","title":"Food and drinking-water safety","words":879,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["food-specific storage and cooking exceptions","validated treatment for individual contaminants and private wells","local advisories and outbreak information","Date labeling and product exceptions by jurisdiction, validated storage after opening and specific microbial hazards."]},{"article_id":"metabolic-health","title":"Insulin resistance and metabolic health","words":1338,"questions":14,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["type 1 diabetes and uncommon diabetes forms","long-term prevention durability and population-specific effects","complete metabolic intervention and adverse-effect comparisons","Current operational definitions by population/jurisdiction, full cardiometabolic risk and treatment comparisons, and assay-specific A1C performance."]},{"article_id":"reading-health-evidence","title":"How to read health evidence","words":948,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["full systematic searches for individual health claims","outcome-specific risk-of-bias and certainty appraisal","independent subject-matter review","Protocol/result matching, prespecified outcomes, full methods, disclosure and harms appraisal for each referenced study."]},{"article_id":"cancer-foundations","title":"Cancer: biology, diagnosis, and treatment","words":844,"questions":13,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["cancer-specific diagnostic criteria, treatment benefits and harms","molecular testing and inherited-risk evaluation","long-term survivorship and recurrence evidence by disease","Cancer-specific grading/staging, assay validation and predictive versus prognostic roles, actionable findings and complete treatment benefits/harms."]},{"article_id":"screening-and-test-errors","title":"Screening: benefits, false results, and overdiagnosis","words":1196,"questions":17,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current country- and risk-specific screening schedules","absolute benefits, false findings and downstream harms by test","test sensitivity, specificity and predictive-value calculations","Current population-specific screening recommendations, with downstream harms and outcomes for the invited population."]},{"article_id":"nervous-system","title":"The nervous system: brain, spinal cord, and nerves","words":1208,"questions":16,"references":14,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["separate disease pages for epilepsy, migraine and other neurological conditions","central versus peripheral diagnostic patterns","condition-specific treatment benefits and harms","Specific examination findings, neurophysiology and imaging limits, neurological disease patterns and treatment comparisons."]},{"article_id":"dementia","title":"Dementia and everyday brain health","words":823,"questions":13,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["complete dementia diagnostic pathways, including delirium and mild cognitive impairment","medicine-specific absolute benefits, monitoring and eligibility by jurisdiction","long-term dementia-incidence prevention trials and caregiver outcomes","Subtype-specific diagnostic criteria, delirium superimposed on dementia, individual prognosis and full current treatment appraisal."]},{"article_id":"chronic-pain","title":"Chronic pain: symptoms, function, and treatment evidence","words":824,"questions":13,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["mechanism- and condition-specific treatment comparisons","absolute benefits, adverse effects and long-term function","procedure evidence and personalized opioid transitions","Mechanistic uncertainty, condition-specific comparisons, mixed presentations and reliable assessment of people with communication difficulties need further coverage."]},{"article_id":"long-covid","title":"Long COVID and post-exertional malaise","words":856,"questions":13,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["completed treatment trials by symptom subgroup and outcome","post-exertional malaise-specific rehabilitation comparisons","pediatric care, alternative diagnoses and local care pathways","Definition validation across settings, updated mechanisms and interventions, population differences and full rehabilitation/PEM evidence."]},{"article_id":"insomnia","title":"Insomnia and cognitive behavioral therapy for insomnia","words":1421,"questions":15,"references":12,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current medicine-specific comparative benefits and harms","complete comparative primary-trial appraisal and long-term treatment durability","insomnia treatment with comorbidities and pediatric populations"]},{"article_id":"sleep-apnea","title":"Sleep apnea: obstruction, breathing signals, and assessment","words":1294,"questions":16,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["absolute symptom and health-outcome benefits of each treatment","negative or inconclusive home testing and complete diagnostic algorithms","central and pediatric apnea care, adherence and medicine-specific harms","Current scoring-rule and device differences, event duration and oxygen burden, pediatric testing and complete treatment comparisons."]},{"article_id":"supplement-medication-interactions","title":"Supplement and medicine interactions","words":825,"questions":13,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["An exhaustive interaction checker with current product labels","Combination-specific incidence and severity","Dose and formulation differences, especially in pregnancy and childhood","Combination-specific current evidence, exposure amounts, timing, route and population effects."]},{"article_id":"biotin-lab-tests","title":"Biotin supplements and laboratory test interference","words":825,"questions":12,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current assay-by-assay susceptibility and mitigation status","Incidence of clinically consequential error by setting","Interference from other supplements and prescribed high-dose treatments","Current platform-specific interference, full correction/method appraisal and validated laboratory mitigation."]},{"article_id":"toxicology-basics","title":"Toxicology: hazard, exposure, and risk","words":714,"questions":13,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["substance-specific dose-response evidence and actual exposure scenarios","mixtures, developmental susceptibility and occupational exposures","validated prevention options and interpretation of commercial exposure tests","Substance-, route-, duration- and population-specific assessment, plus meaningful outcomes of exposure reduction."]},{"article_id":"palliative-care","title":"Palliative care, quality of life, and caregiver support","words":918,"questions":15,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative benefits across diseases and service models","country-specific eligibility, funding and advance-care documents","caregiver outcomes and symptom-treatment adverse effects","Advance-planning processes, current local legal documents, disagreement and capacity, caregiver outcomes and treatment-specific goals need fuller coverage."]},{"article_id":"biomarkers-and-outcomes","title":"Biomarkers, surrogate endpoints, and actual health outcomes","words":974,"questions":14,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["individual aging-test validation and reproducibility","full drug-specific surrogate validation and confirmatory outcomes","measurement error and consequences of repeated low-risk testing","Full source-to-claim appraisal and purpose-specific performance, decision benefit and patient outcomes."]},{"article_id":"understanding-risk","title":"Understanding absolute risk, relative effects, and uncertainty","words":1244,"questions":15,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.8","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["predictive values and worked test-accuracy examples","competing risks and detailed time-to-event interpretation","complete outcome-specific uncertainty and harms appraisal","Outcome-specific absolute effects and appropriate interval estimates in the populations a reader is comparing."]},{"article_id":"protein-needs","title":"Protein needs","words":2060,"questions":19,"references":18,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary systematic synthesis of protein source, timing, and functional outcomes","Pregnancy, childhood, and condition-specific guidance in dedicated articles","Independent review of extreme long-duration intakes","Independent comparative review of US dietary targets, European adequacy references, and long-term patient-important outcomes","Current product comparisons, allergy and intolerance context, and meaningful long-term functional outcomes.","Direct and long-term comparisons of meal timing, meaningful physical function and special populations remain unresolved; the correction disclosure is now accessible."]},{"article_id":"magnesium-and-sleep","title":"Magnesium and sleep","words":1038,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.7","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Longer objective sleep trials and comparisons between formulations","Reliable deficiency-defined responder groups","Condition-specific and interaction safety beyond this selected-source overview","Full outcome-specific comparisons of formulations, with adequate nutritional-status measurement and clinically meaningful sleep outcomes."]},{"article_id":"zone-2-training","title":"Zone 2 training","words":1416,"questions":14,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Direct comparisons with matched exercise volume in general-population adults","Disease-specific exercise eligibility and safety","Long-term health outcomes and measurement agreement across devices","Full threshold-method validation, modality/population differences, funding and study dependence, and direct health-outcome comparisons."]},{"article_id":"probiotics","title":"Probiotics","words":1400,"questions":15,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.7","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current strain-by-strain syntheses for each indication","International guideline differences and newer studies after the cited guideline","Long-term outcomes and product-specific viability/contamination testing","Product-specific benefit and safety evidence for synbiotics and postbiotics; no class-wide superiority claim is established."]},{"article_id":"cholesterol-and-lipids","title":"Cholesterol and blood lipids","words":1570,"questions":18,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["absolute event reductions and harms by treatment and baseline risk","familial hypercholesterolemia and pregnancy-specific care","other countries’ lipid guidelines","Current FH diagnostic/family-screening pathways, condition-specific triglyceride evaluation, pregnancy care and absolute treatment benefits/harms."]},{"article_id":"acne","title":"Acne: what it is and how treatments differ","words":896,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["pregnancy-specific medicine safety","independent synthesis of diet, supplements, and light-device claims","absolute comparative benefits and harms of individual regimens"]},{"article_id":"migraine","title":"Migraine: attacks, triggers, and treatment approaches","words":1042,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative absolute benefits and harms of individual medicines","newer preventive therapies and pregnancy-specific evidence","pediatric, vestibular and chronic migraine details"]},{"article_id":"travel-health","title":"Travel health: preparation, vaccines, and destination risks","words":1189,"questions":15,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["current country-by-country requirements and outbreak notices","malaria medicine and vaccine suitability for particular itineraries","altitude, jet lag, air travel, injuries, and medical evacuation evidence","Altitude-illness syndromes and emergency recognition, ascent-specific evidence, jet-lag treatment comparisons and individualized itineraries."]},{"article_id":"adhd","title":"ADHD: diagnosis, support, and treatment","words":1397,"questions":11,"references":12,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["adult-specific comparative treatment evidence","long-term benefits and harms by medicine","coexisting autism, learning difficulties, and condition-specific accommodations"]},{"article_id":"depression-treatment","title":"Depression: treatment options and their limits","words":1461,"questions":12,"references":12,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["psychotherapy-by-psychotherapy comparisons","long-term relapse prevention and treatment-resistant strategies","child, adolescent, bipolar, and perinatal treatment reviews"]},{"article_id":"endometriosis","title":"Endometriosis: symptoms, diagnosis, and care","words":1272,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["comparative pain-treatment benefits and harms","surgical outcomes, recurrence, and fertility-specific decisions","diagnostic performance by lesion type and specialist imaging expertise","Subtype-specific treatment and fertility comparisons, coexistence with adenomyosis and classification validity beyond these selected definitions."]},{"article_id":"type-2-diabetes","title":"Type 2 diabetes","words":1047,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["complete drug-class comparisons and current cardiorenal outcome guidance","remission rates and durability for individual lifestyle, medicine and surgery approaches","pregnancy, pediatric type 2 diabetes and uncommon diagnostic forms","Current emergency diagnostic criteria and overlap, individualized low-glucose prevention and full outcome comparisons of medicines."]},{"article_id":"glp-1-medicines","title":"GLP-1 and dual-incretin medicines","words":1183,"questions":11,"references":14,"depth_status":{"status":"expanded_explainer","edition":"3.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["complete current product-label indications, age groups and formulation-specific restrictions by country","long-term absolute benefits and harms, head-to-head trials and maintenance strategies","pregnancy, contraceptive interactions, procedures, muscle/function outcomes and investigational agents"]},{"article_id":"sauna","title":"Sauna and heat exposure","words":1293,"questions":16,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Clinical-outcome trials, modality-specific comparisons, pregnancy and unstable-disease safety, fertility, optimal exposure and combined cold/heat routines need dedicated review. The selected evidence does not establish a personal temperature, duration or frequency prescription.","Long-term comparisons across dry sauna, infrared sauna, steam rooms and other passive-heating exposures.","Controlled fertility/live-birth research, modern pregnancy-specific exposures and comprehensive clinical harms remain incomplete; these selected sources do not establish a personal regimen."]},{"article_id":"caffeine","title":"Caffeine: coffee, alertness, performance, and sleep","words":1049,"questions":14,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term clinical effects of particular beverage patterns and doses.","Safe individualized timing in pregnancy, illness, childhood and medicine use.","Population- and product-specific effects, including combinations with other energy-drink ingredients.","Dose/timing sensitivity, reliable individual measurement and long-term clinical outcomes require separate evidence; short trials do not settle those questions."]},{"article_id":"vitamin-d","title":"Vitamin D: deficiency, testing, and supplementation","words":1876,"questions":14,"references":15,"depth_status":{"status":"expanded_explainer","edition":"3.7","independent_expert_review":false,"supplemental_depth1_checked_at":"2026-10-20"},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Deficiency treatment and monitoring in kidney disease or malabsorption.","Outcome-specific benefits in underrepresented populations and differing regimens.","Independent comparisons of diagnostic thresholds, assay performance and condition-specific treatment outcomes."]},{"article_id":"omega-3","title":"Omega-3s: foods, fish oil, and prescription EPA","words":1876,"questions":13,"references":15,"depth_status":{"status":"expanded_explainer","edition":"3.7","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Outcome-specific evidence for pregnancy, cognition, eye disease and psychiatric uses.","How formulation and comparator differences explain conflicting cardiovascular results.","Complete final 2026 rhythm-risk analysis, subgroup-interaction and absolute-harm appraisal, with overlapping reviews deduplicated."]},{"article_id":"melatonin","title":"Melatonin: body-clock timing, sleep, and product quality","words":1681,"questions":13,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.7","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term developmental outcomes and pediatric condition-specific comparisons.","Optimal timing and formulation for particular circadian disorders.","Later peer-reviewed safety results and condition-specific trials, with exposure misclassification and residual confounding independently appraised."]},{"article_id":"dietary-fiber","title":"Dietary fibre: types, foods, gut symptoms, and supplements","words":1269,"questions":12,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual fibre properties and product-specific efficacy beyond broad soluble/insoluble categories.","Diets in bowel obstruction, active disease, surgery and feeding disorders.","Condition-specific comparisons of physicochemical properties, symptom outcomes, dose and tolerability; normal-bowel models do not establish a universal fibre choice."]},{"article_id":"strength-training","title":"Strength training: what matters, what varies, and what is uncertain","words":1311,"questions":16,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Condition-specific rehabilitation, pregnancy, childhood and elite-sport programming.","Long-term harms and causal effects on disease or lifespan.","Goal-specific terminology and dosing, full current review appraisal, special populations, technique and long-term benefit/harms comparisons.","Individual response, indirect-set coding, full model appraisal and clinical-population comparisons remain unresolved; fitted curves do not supply personal prescriptions."]},{"article_id":"irritable-bowel-syndrome","title":"Irritable bowel syndrome: symptoms, subtypes, and treatment evidence","words":1253,"questions":9,"references":12,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative effects and harms of individual medicines and probiotics.","Pediatric IBS and long-term nutritional outcomes of restrictive diets."]},{"article_id":"asthma","title":"Asthma: airway inflammation, diagnosis, inhalers, and action plans","words":1018,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Detailed pediatric pathways and severe-asthma biologic comparisons.","Country-specific inhaler availability, licensing and action-plan protocols."]},{"article_id":"pcos","title":"PCOS / PMOS: hormones, metabolic health, periods, and fertility","words":1176,"questions":8,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Reconcile inositol reviews by formulation, comparator, outcome, study overlap and risk of bias.","Adolescent and postmenopausal care, and complete comparative treatment harms."]},{"article_id":"eating-disorders","title":"Eating disorders: types, recognition, support, and recovery","words":982,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current comparative treatment effects for each eating disorder, age and care setting.","ARFID, OSFED and culturally diverse care require dedicated deeper articles."]},{"article_id":"anxiety-disorders","title":"Anxiety disorders: worry, panic, social fear, and treatment","words":1520,"questions":11,"references":16,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative effects for children, pregnancy and co-occurring conditions need separate reviews.","Phobias, agoraphobia, OCD and trauma-related conditions need dedicated explanations."]},{"article_id":"acid-reflux","title":"Acid reflux and GERD: symptoms, tests, and treatment","words":1254,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative long-term treatment harms and surgery outcomes need deeper outcome-specific synthesis.","Children, pregnancy, Barrett’s surveillance and reflux hypersensitivity need dedicated articles."]},{"article_id":"osteoarthritis","title":"Osteoarthritis: joint changes, pain, movement, and care","words":1049,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term structural outcomes and comparative surgery or injection effects need deeper reviews.","Evidence for each joint, disability, multimorbidity and flare-management approach needs expansion."]},{"article_id":"stroke","title":"Stroke and TIA: types, warning signs, treatment, and recovery","words":793,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Detailed hemorrhagic-stroke, pediatric, pregnancy and recurrence pathways require separate articles.","Comparative rehabilitation and long-term outcome evidence needs deeper review."]},{"article_id":"allergic-rhinitis","title":"Allergic rhinitis: hay fever, triggers, medicines, and nasal rinses","words":834,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Immunotherapy, confirmatory testing and treatment in young children or pregnancy need separate reviews.","Perennial allergy, mixed rhinitis and long-term comparative outcomes need deeper synthesis."]},{"article_id":"vitamin-b12","title":"Vitamin B12: foods, deficiency, blood tests, and replacement","words":1106,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Clinical neurological outcomes for specific causes and regimens need deeper comparative synthesis.","Pregnancy, infant deficiency, nitrous oxide exposure and autoimmune gastritis need dedicated explanations."]},{"article_id":"type-1-diabetes","title":"Type 1 diabetes: insulin, monitoring, emergencies, and newer therapies","words":1026,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current automated-delivery comparisons, accessibility and patient-important outcomes need deeper review.","Autoantibody screening, disease staging, pregnancy and immune-therapy follow-up need dedicated articles."]},{"article_id":"detoxes-and-cleanses","title":"Detoxes and cleanses: what the claims mean, evidence, and risks","words":674,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Product-specific testing and subsequent trials need separate updated reviews.","Poisoning management, substance withdrawal and medically required bowel preparation are separate subjects."]},{"article_id":"red-light-therapy","title":"Red light therapy: wavelengths, clinical uses, and wellness claims","words":1336,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.7","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Device-specific replication and longer follow-up for meaningful benefits and harms.","Complete outcome-specific trial appraisal, review overlap and newer evidence since December 2023.","Condition- and device-specific benefit, durability and adverse effects, using measured target parameters."]},{"article_id":"acupuncture","title":"Acupuncture: comparators, chronic pain, safety, and guideline disagreement","words":707,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated condition-specific effect sizes, durability, adverse-event rates and comparator appraisal.","Differences by technique, patient group, practitioner qualifications and local costs."]},{"article_id":"hyperbaric-oxygen","title":"Hyperbaric oxygen: medical uses, wellness chambers, and aging claims","words":712,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current patient-important benefits and harms for each individual medical indication.","Controlled healthy-aging trials, durable clinical outcomes and device-specific applicability."]},{"article_id":"whole-body-mri","title":"Whole-body MRI: screening, incidental findings, and who the evidence 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infection, perforated eardrum and persistent-fluid assessment."]},{"article_id":"sinusitis","title":"Sinusitis: inflammation, acute versus chronic symptoms, antibiotics, and safe rinsing","words":1025,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current guideline and treatment comparisons for chronic rhinosinusitis, including polyp subtypes.","Independent evidence for irrigation, steroid preparations, surgery, biologics and recurrent unilateral symptoms."]},{"article_id":"restless-legs-syndrome","title":"Restless legs syndrome: symptom pattern, iron, augmentation, and changing guidance","words":937,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent current comparisons of treatment benefits, augmentation risks and longer-term harms.","Full international endorsement appraisal, PLMD, pediatric/pregnancy/renal care and device-specific evidence."]},{"article_id":"heart-failure","title":"Heart failure: pumping, filling, ejection fraction, tests, and care goals","words":1057,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary comparisons and absolute benefits/harms by heart-failure subtype.","Dedicated pages for cardiomyopathy, valve disease, device selection, reversible causes and pregnancy/pediatric care."]},{"article_id":"coronary-heart-disease","title":"Coronary disease: arteries, angina, tests, stents, and evidence limits","words":932,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete contemporary guideline comparisons, absolute outcome estimates and symptom benefits by population.","Dedicated accounts of acute coronary syndromes, microvascular/spasm testing, left-main disease and procedure-specific harms."]},{"article_id":"atrial-fibrillation","title":"Atrial fibrillation: rhythm, rate, stroke risk, tests, and follow-up","words":887,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current comparative trials and absolute benefits/harms by symptom burden, stroke risk and procedure.","Device-detected brief episodes, post-ablation anticoagulation research, valve-related AF and pregnancy-specific care require fuller review."]},{"article_id":"venous-blood-clots","title":"Venous blood clots: DVT, pulmonary embolism, tests, and treatment roles","words":911,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Absolute recurrence/bleeding estimates and comparative treatment evidence by risk group.","Dedicated accounts of thrombophilia, superficial vein thrombosis, post-thrombotic syndrome and chronic thromboembolic pulmonary hypertension."]},{"article_id":"copd","title":"COPD: emphysema, bronchitis, spirometry, rehabilitation, and targeted therapies","words":887,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete current guideline and regulatory inventory, comparative biologic trials and long-term benefit/harms.","Dedicated alpha-1 antitrypsin, bronchiectasis, oxygen-safety and procedure/rehabilitation evidence accounts."]},{"article_id":"pneumonia","title":"Pneumonia: causes, settings, tests, antibiotics, severity, and recovery","words":862,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Absolute benefits/harms and full contemporary comparisons by pathogen, age and severity.","Dedicated aspiration pneumonitis/swallowing, ventilator-associated disease, vaccination targets and organism-specific accounts."]},{"article_id":"hypothyroidism","title":"Hypothyroidism: hormones, Hashimoto disease, blood tests, replacement, and T3 uncertainty","words":924,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent appraisal of contemporary T4/T3 effectiveness and safety research, including outcomes relevant to persistent symptoms.","Dedicated pregnancy/congenital/central care, absorption interactions, thyroiditis and specialist selection for combination therapy."]},{"article_id":"hyperthyroidism","title":"Hyperthyroidism: Graves disease, thyroiditis, tests, and different treatment goals","words":899,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent contemporary comparative evidence for medicines, radioiodine and surgery by cause and risk group.","Dedicated thyroid-eye disease, pregnancy, toxic nodules, subclinical treatment decisions and each thyroiditis type."]},{"article_id":"hives-and-urticaria","title":"Hives: acute, chronic, spontaneous, inducible, and deeper swelling","words":758,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent current guideline appraisal, comparative therapies and longer-term benefits/harms by urticaria type.","Dedicated chronic spontaneous disease, hereditary/drug-related angioedema, urticarial vasculitis and pediatric care."]},{"article_id":"shingles","title":"Shingles: reactivation, rash, nerve pain, transmission, treatment, and vaccination","words":830,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent current synthesis of vaccine durability, rare harms and benefits across immune states and products.","Dedicated postherpetic-neuralgia care, ophthalmic/Ramsay Hunt complications, atypical rash diagnosis and national vaccination comparisons."]},{"article_id":"breathwork","title":"Breathwork: slow breathing, sighing, holds, stress outcomes, and safety","words":651,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Better blinded or expectation-matched studies, clinical populations, long-term outcomes and systematic harms reporting.","The optimal technique or dose is unresolved; physiological mechanisms do not establish clinical benefit."]},{"article_id":"yoga","title":"Yoga: practices, pain and anxiety studies, comparison groups, and adaptation","words":722,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Reliable absolute benefits and harms by style, instructor, participant characteristics and long-term adherence.","Pregnancy, children and individual clinical conditions require fuller dedicated assessment; a broad class label is insufficient."]},{"article_id":"meditation","title":"Meditation: mindfulness, structured courses, apps, benefits, and difficult experiences","words":693,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which specific programs improve meaningful longer-term outcomes for particular populations.","Reliable harms ascertainment, trauma-sensitive adaptation, program accessibility and direct app comparisons remain incomplete."]},{"article_id":"tai-chi-and-qigong","title":"Tai chi and qigong: movement traditions, balance, symptoms, and study limits","words":696,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current independent synthesis across specific qigong forms and comparators; reviews may reuse the same trials.","Absolute fall benefits by baseline risk, longer-term adherence, accessibility and condition-specific safety need fuller evaluation."]},{"article_id":"massage","title":"Massage: techniques, symptom relief, sports recovery, lymphatic care, and limits","words":646,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.17","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current condition-specific effect sizes, credible controls, durability and systematic harms reporting.","Percussion devices and other branded methods require separate evidence; therapist skill and context are incompletely captured in trials."]},{"article_id":"collagen-supplements","title":"Collagen supplements: proteins, peptides, skin and joint evidence, and bias","words":1163,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent, adequately blinded and standardized product trials with clinically meaningful outcomes and longer safety follow-up.","Resolve study overlap, sponsorship/design confounding, preparation-specific effects and absolute benefits before stronger conclusions."]},{"article_id":"ashwagandha","title":"Ashwagandha: preparations, stress and sleep research, interactions, and liver alerts","words":855,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Preparation-specific longer-term benefit/harms, independent replication and clinically meaningful insomnia/anxiety outcomes.","Regulator reports lack an all-user denominator; product attribution, co-exposures and vulnerable groups need fuller analysis."]},{"article_id":"turmeric-and-curcumin","title":"Turmeric and curcumin: food, extracts, absorption, clinical outcomes, and liver risk","words":1161,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Formulation-specific long-term effects, absolute benefits and harms, independent replication and clinically important outcomes.","No full current synthesis for metabolic, mood or other promoted uses; safety-report counts do not supply incidence or a product-risk ranking."]},{"article_id":"electrolyte-drinks","title":"Electrolyte drinks: minerals, sweat, carbohydrate, water, and oral rehydration","words":1258,"questions":11,"references":11,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current product-specific composition, independent testing and meaningful comparative outcomes.","Endurance-event plans, pediatric illness, pregnancy, kidney/heart disease and medicine effects need fuller tailored evidence pathways."]},{"article_id":"compression-garments","title":"Compression garments and recovery boots: medical uses, strength, soreness, and performance","words":779,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.17","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independently reconcile study overlap, pressure/fit, sham credibility, statistical methods and clinically meaningful outcome sizes.","Full current device safety assessment and disease-specific medical indications require dedicated review; biomarker/mechanical changes cannot establish every performance claim."]},{"article_id":"vitamin-c","title":"Vitamin C: foods, deficiency, colds, supplements, and intravenous claims","words":856,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["An updated cold synthesis, independently appraised clinical trials and current disease-specific IV evidence remain outside this selected overview.","Individual dosing, diagnosis and interactions require clinical assessment."]},{"article_id":"multivitamins","title":"Multivitamins: formulas, nutrient gaps, cognition, biological-age clocks, and lifespan claims","words":1268,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent reconciliation of all COSMOS reports, trial overlap, missingness, multiplicity and clinical outcomes remains incomplete.","A current comprehensive prevention review, formula comparisons and qualified clinical review are still needed."]},{"article_id":"zinc","title":"Zinc: foods, supplement forms, colds, copper balance, and clinical uses","words":912,"questions":11,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Optimal cold formulation, timing and systematic serious-harm reporting remain unresolved.","Full disease-specific guidance, current interaction assessment and qualified review are pending."]},{"article_id":"vitamin-a","title":"Vitamin A: retinol, carotenoids, deficiency, pregnancy, and smoker supplement trials","words":753,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current population-specific guidance, clinical deficiency assessment and qualified review remain incomplete.","These selected supplement trials do not establish the effect of every food, form, dose or retinoid medicine."]},{"article_id":"vitamin-e","title":"Vitamin E: forms, foods, antioxidant claims, bleeding, and cancer trials","words":794,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent full-text appraisal, current medication-specific safety guidance and qualified review are unfinished.","Evidence for one formulation or outcome cannot settle all vitamin E compounds and conditions."]},{"article_id":"calcium","title":"Calcium: foods, carbonate and citrate, blood levels, bones, and fracture evidence","words":936,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full current fracture-evidence synthesis, disease-specific treatment guidance and medication interaction assessment remain incomplete.","The draft’s future finalization should trigger an update; individual intake and laboratory interpretation are not supplied."]},{"article_id":"vitamin-b6","title":"Vitamin B6: forms, foods, nerve toxicity, intake limits, and changing regulation","words":755,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual dose-duration risk, current product composition and independent clinical review remain unresolved.","A full current efficacy review of all B6 indications and medication contexts is outside this overview."]},{"article_id":"folate","title":"Folate: food folate, folic acid, methylfolate, pregnancy, MTHFR, and B12","words":765,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full current pregnancy and genotype-specific evidence review and qualified review remain unfinished.","This overview does not set individual intake, interpret rare disorders or resolve medication-specific interactions."]},{"article_id":"iodine","title":"Iodine: thyroid hormones, iodized salt, seaweed variability, pregnancy, and radiation medicines","words":814,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current local pregnancy guidance, independently updated trials and population iodine surveillance remain outside this overview.","No individual thyroid treatment or emergency-medicine schedule is provided; qualified review remains pending."]},{"article_id":"selenium","title":"Selenium: foods, forms, excess, cancer prevention, and thyroid-marker evidence","words":718,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent updated cancer and thyroid reviews, clinically important thyroid endpoints and longer-term safety remain incomplete.","Qualified review, individualized intake assessment and full disease-specific treatment guidance are pending."]},{"article_id":"influenza","title":"Influenza: flu types, symptoms, tests, vaccines, and antiviral evidence","words":725,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current-season vaccine products, full antiviral comparisons, resistance surveillance and qualified review remain incomplete.","This page does not diagnose an illness or choose a medication, dose or personal return-to-work date."]},{"article_id":"covid-19","title":"COVID-19: transmission, tests, severe-risk context, prevention, and changing antiviral evidence","words":755,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full updated treatment and prevention synthesis, current local vaccine guidance and qualified review are unfinished.","The newer trials need full independent appraisal, including power, eligibility, adherence and severe immunosuppression applicability."]},{"article_id":"norovirus","title":"Norovirus: stomach bugs, spread, hydration, cleaning, and vaccine-study limits","words":1172,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current vaccine-development and authorization status, strain coverage and independent clinical review remain incomplete.","This page does not identify an individual’s pathogen or provide child-specific fluid quantities or triage."]},{"article_id":"hepatitis-b","title":"Hepatitis B: acute and chronic infection, blood tests, vaccination, suppression, and pregnancy","words":556,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current treatment eligibility, fibrosis/cancer monitoring and maternal/infant prevention guidance need independent review.","This page does not interpret individual serology, choose a regimen or resolve every pregnancy risk."]},{"article_id":"hepatitis-c","title":"Hepatitis C: bloodborne infection, antibody versus RNA, cure, reinfection, and liver follow-up","words":616,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full independent antiviral trial synthesis, regimen comparisons and current local access assessment remain unfinished.","Clinical interpretation, individualized treatment and qualified review remain pending."]},{"article_id":"hiv","title":"HIV: infection versus AIDS, test windows, treatment, U=U, PrEP, and PEP","words":590,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current treatment/PrEP comparisons, pregnancy/infant pathways and independent qualified review are incomplete.","Individual exposure assessment, test interpretation and prescriptions are outside this educational page."]},{"article_id":"hpv","title":"HPV: virus types, persistence, warts, cancer prevention, screening, and positive results","words":584,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current jurisdiction-specific vaccination/screening guidance and a complete cancer-site evidence review remain incomplete.","Individual test interpretation, lesion management and qualified review are pending."]},{"article_id":"chlamydia","title":"Chlamydia: silent infection, anatomical-site tests, treatment evidence, partners, and repeat testing","words":674,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated jurisdiction-specific screening and treatment guidance, full LGV coverage and independent review remain incomplete.","No individual antibiotic regimen, diagnosis or partner-notification action is provided."]},{"article_id":"gonorrhea","title":"Gonorrhea: genital, throat and rectal infection, resistance, follow-up tests, and partial vaccine protection","words":591,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full updated antibiotic and vaccine-evidence synthesis, local resistance data and independent review remain incomplete.","No individual eligibility decision, antibiotic selection or test interpretation is provided."]},{"article_id":"tuberculosis","title":"Tuberculosis: infection versus disease, airborne spread, tests, BCG, and resistant-TB treatment","words":719,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full diagnostic pathways, current resistance-guided regimens, extrapulmonary TB and independent review remain incomplete.","The page does not interpret a personal test, establish infectiousness or select a treatment duration."]},{"article_id":"common-cold","title":"Common cold: viral causes, overlapping symptoms, recovery, medicines, and antibiotic evidence","words":687,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A complete current symptom-treatment and supplement review, pathogen-specific distinctions and qualified review remain incomplete.","No individual diagnosis, antibiotic choice or pediatric medication dose is supplied."]},{"article_id":"mononucleosis","title":"Mononucleosis: glandular fever, EBV, antibody tests, fatigue, steroids, and spleen precautions","words":684,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated steroid/antiviral synthesis, detailed return-to-sport guidance and qualified review remain incomplete.","No diagnosis of chronic active EBV, personal serology interpretation or activity clearance is supplied."]},{"article_id":"lyme-disease","title":"Lyme disease: tick exposure, changing rash, antibody tests, antibiotics, and persistent symptoms","words":736,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A current complete treatment/prophylaxis synthesis, regional vectors and persistent-symptom mechanisms remain incomplete.","No personal diagnosis, tick-risk calculation, serology interpretation or antibiotic regimen is supplied."]},{"article_id":"syphilis","title":"Syphilis: stages, silent infection, paired blood tests, pregnancy, cure, and follow-up","words":627,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current full stage-specific, pregnancy and infant treatment protocols and independent review remain incomplete.","No personal stage assignment, antibody interpretation or antibiotic regimen is supplied."]},{"article_id":"genital-herpes","title":"Genital herpes: HSV types, hidden transmission, test limits, recurrence, and antiviral suppression","words":614,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.22","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated full prevention/treatment comparisons, precise trial follow-up appraisal and pregnancy protocols remain incomplete.","No individual antibody interpretation, source-partner determination or medication/delivery plan is supplied."]},{"article_id":"trichomoniasis","title":"Trichomoniasis: a protozoan STI, silent infection, test methods, treatment comparisons, and reinfection","words":699,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A current full screening/treatment synthesis, recurrent-infection pathways and independent review remain incomplete.","No diagnosis from symptoms, personal regimen or pregnancy outcome prediction is supplied."]},{"article_id":"scabies","title":"Scabies: itch mites, ordinary and crusted infestation, contact care, treatment, and lingering itch","words":684,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A current full treatment-comparison, resistance and institutional-outbreak review remains incomplete.","No individual rash diagnosis, product application plan or contact-treatment prescription is supplied."]},{"article_id":"ringworm","title":"Ringworm: dermatophyte fungi, body-site names, lookalikes, antifungals, and emerging resistance","words":759,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.22","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparative antifungal review, current regional resistance surveillance and independent review remain incomplete.","No individual rash/nail diagnosis, susceptibility prediction or oral-antifungal regimen is supplied."]},{"article_id":"head-lice","title":"Head lice: live infestation versus nits, transmission, combing, treatment choices, and school guidance","words":631,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full product-comparison, resistance and school-policy review and independent clinical review remain incomplete.","No individual infestation diagnosis, product choice or application calendar is supplied."]},{"article_id":"measles","title":"Measles: airborne infection, complications, MMR protection, testing, and vitamin A limits","words":669,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full vaccine-effectiveness and rare-harm synthesis, local exposure protocols and independent clinical review remain incomplete.","No personal diagnosis, vaccine eligibility decision, supplement dose or exposure-management plan is supplied."]},{"article_id":"tooth-decay","title":"Tooth decay: caries, early mineral loss, cavities, fluoride evidence, and ongoing prevention","words":748,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.23","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A complete updated prevention and restoration comparison and independent clinical review remain incomplete.","No personal lesion diagnosis, fluoride strength or dental procedure is selected."]},{"article_id":"gum-disease","title":"Gum disease: gingivitis versus periodontitis, plaque, pockets, care, and whole-body evidence","words":666,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current full treatment comparisons, systemic clinical outcomes and independent expert reconciliation remain incomplete.","No personal pocket interpretation, disease stage or periodontal procedure is supplied."]},{"article_id":"tooth-sensitivity","title":"Tooth sensitivity: exposed dentin, other pain causes, toothpaste evidence, and assessment","words":828,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A current full product/procedure comparison and independent review remain incomplete.","No individual tooth diagnosis, brand choice or dental procedure is supplied."]},{"article_id":"mouth-ulcers","title":"Mouth ulcers: aphthous types, other causes, treatment uncertainty, and persistent-sore assessment","words":656,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["An updated topical/systemic treatment synthesis, diagnostic pathways and independent review remain incomplete.","No personal lesion diagnosis, deficiency interpretation, allergy conclusion or medication mixture is supplied."]},{"article_id":"dry-mouth","title":"Dry mouth: xerostomia, saliva function, medicines, other causes, and treatment evidence limits","words":667,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A current full product and gland-treatment synthesis, cause-specific pathways and independent review remain incomplete.","No medication change, salivary test interpretation or autoimmune diagnosis is supplied."]},{"article_id":"bruxism","title":"Bruxism: awake and sleep jaw activity, updated definitions, tooth damage, and treatment outcomes","words":925,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A current full treatment/safety synthesis, sleep-disorder links and independent clinical review remain incomplete.","No individual activity diagnosis, appliance choice or medication change is supplied."]},{"article_id":"temporomandibular-disorders","title":"Temporomandibular disorders: TMJ versus TMD, muscle and joint pain, assessment, and treatment uncertainty","words":703,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full current guideline reconciliation, structural-disease pathways and independent expert review remain incomplete.","No personal jaw diagnosis, appliance selection, self-manipulation or surgical decision is supplied."]},{"article_id":"bad-breath","title":"Bad breath: halitosis, oral and other causes, masking versus control, and uncertain product rankings","words":804,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated product comparisons, nonoral diagnostic pathways and independent clinical review remain incomplete.","No individual odor diagnosis, organ-disease inference or rinse prescription is supplied."]},{"article_id":"wisdom-teeth","title":"Wisdom teeth: third molars, impaction, symptoms versus disease, removal, and surveillance","words":867,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current full guideline reconciliation, long-term/rare outcomes and independent clinical review remain incomplete.","No personal extraction decision, imaging interpretation, antibiotic plan or surveillance interval is supplied."]},{"article_id":"teeth-whitening","title":"Teeth whitening: stain types, bleaching versus cleaning, restorations, added light, and safety","words":710,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current full product/light comparisons, the stronger NHS wording and independent clinical reconciliation remain incomplete.","No personal peroxide dose, whitening protocol, cosmetic diagnosis or cross-border legal conclusion is supplied."]},{"article_id":"erectile-dysfunction","title":"Erectile dysfunction: erections, desire, underlying causes, treatment options, and enhancement claims","words":579,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.24","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, current head-to-head care comparisons and full shockwave trial appraisal remain incomplete.","No personal diagnosis, hormone result, drug regimen or enhancement protocol is supplied."]},{"article_id":"benign-prostatic-hyperplasia","title":"Benign prostate enlargement: urinary symptoms, size, cancer distinctions, care choices, and saw palmetto","words":687,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent review and current head-to-head medicine/procedure comparisons remain incomplete.","No personal PSA interpretation, urinary diagnosis, supplement regimen or procedure is selected."]},{"article_id":"uterine-fibroids","title":"Uterine fibroids: location, bleeding and pressure, treatment goals, fertility, and comparative evidence","words":668,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.24","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated comparisons across all medicines and procedures, reproductive outcomes and independent review remain incomplete.","No personal scan interpretation, bleeding diagnosis or fertility-preserving procedure is selected."]},{"article_id":"ovarian-cysts","title":"Ovarian cysts: functional versus other types, ultrasound features, observation, surgery, and follow-up differences","words":601,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.24","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent updated mass-management review and comparison of all current therapies remain incomplete.","No personal ultrasound interpretation, cancer prediction, follow-up interval or operation is selected."]},{"article_id":"dysmenorrhea","title":"Painful periods: primary versus secondary dysmenorrhea, prostaglandins, care options, and evidence limits","words":721,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated comparisons, broader functional outcomes and independent clinical review remain incomplete.","No personal pelvic diagnosis, painkiller dose, contraceptive choice or exercise prescription is supplied."]},{"article_id":"pms-and-pmdd","title":"PMS and PMDD: cycle-linked symptoms, prospective tracking, premenstrual exacerbation, and treatment evidence","words":672,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current guideline appraisal, updated head-to-head options and independent psychiatric/gynecological review remain incomplete.","No personal PMS/PMDD diagnosis, medicine schedule or hormone-suppression protocol is supplied."]},{"article_id":"vaginal-yeast-infections","title":"Vaginal yeast infections: symptoms versus colonization, recurrent thrush, antifungals, and probiotic uncertainty","words":614,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.24","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent review, full newer probiotic-trial appraisal and comprehensive current drug comparisons remain incomplete.","No personal infection diagnosis, antifungal regimen, probiotic protocol or prescription eligibility decision is supplied."]},{"article_id":"bacterial-vaginosis","title":"Bacterial vaginosis: vaginal dysbiosis, diagnosis, recurrence, changing partner evidence, and pregnancy screening","words":639,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.24","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full update appraisal, evidence in additional partner settings and independent clinical review remain incomplete.","No personal BV diagnosis, antibiotic regimen or partner treatment decision is supplied."]},{"article_id":"perimenopause","title":"Perimenopause: the transition, changing symptoms, diagnosis, treatment purposes, and recent hormone-label changes","words":1167,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current product-label appraisal, timing-specific mortality reconciliation and independent specialist review remain incomplete.","No personal hormone result, menopause diagnosis, HRT regimen or contraceptive choice is supplied."]},{"article_id":"gestational-diabetes","title":"Gestational diabetes: pregnancy glucose changes, screening versus diagnosis, care goals, early evidence, and follow-up","words":848,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.24","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent current diagnostic/medication review, complete early-screening reconciliation and long-term outcomes remain incomplete.","No personal glucose interpretation, pregnancy diet, medicine regimen or screening decision is supplied."]},{"article_id":"breast-cancer","title":"Breast cancer: tissue types, receptors, stage and grade, screening, and treatment purposes","words":724,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, complete subtype-specific comparative evidence and long-term treatment trade-offs remain incomplete.","The selected NCI pages are related explanations, not seven independent trials or an exhaustive screening synthesis."]},{"article_id":"prostate-cancer","title":"Prostate cancer: PSA, grade and stage, surveillance, treatment trade-offs, and long-term trial evidence","words":734,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, current risk-adapted screening reconciliation and complete modern treatment comparisons remain incomplete.","ProtecT is one randomized cohort; agency pages are related explanations rather than independent replication."]},{"article_id":"colorectal-cancer","title":"Colorectal cancer: colon and rectum, polyps, screening choices, newer blood tests, and treatment goals","words":799,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, complete current screening-guideline reconciliation and all newer test comparisons remain incomplete.","ECLIPSE is a diagnostic study, not a prevention trial; approval and performance documents share the same underlying evidence."]},{"article_id":"lung-cancer","title":"Lung cancer: cell types, risk beyond smoking, staging, tumor tests, and screening disagreements","words":825,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, complete subtype-specific treatment comparisons and all regional screening frameworks remain incomplete.","The guidelines share underlying trials; two organizations do not represent two independent replications."]},{"article_id":"cervical-cancer","title":"Cervical cancer: HPV, precancer, screening and self-collection, diagnosis, and treatment purposes","words":749,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, complete current screening-guideline comparison and subtype-specific treatment evidence remain incomplete.","The regulator record and guideline explain different scopes; neither supplies a home cancer diagnosis."]},{"article_id":"melanoma","title":"Melanoma: pigment cells, changing marks, ABCDE limits, tumor depth, and treatment purposes","words":743,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, full subtype-specific systemic-treatment evidence and all ocular/mucosal approaches remain incomplete.","No photograph, checklist, gene result or surface measurement is interpreted as a personal cancer diagnosis."]},{"article_id":"non-melanoma-skin-cancer","title":"Common non-melanoma skin cancers: basal and squamous cells, biopsy, and treatment choices","words":616,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, complete high-risk treatment evidence and all rarer skin cancers remain incomplete.","No photograph, home treatment or population-screening conclusion supplies a personal lesion diagnosis."]},{"article_id":"ovarian-cancer","title":"Ovarian cancer: tissue families, persistent symptoms, CA-125, screening, and treatment purposes","words":713,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, full rare-subtype evidence and current maintenance-drug comparisons remain incomplete.","No CA-125, ultrasound, inherited finding or symptom pattern is interpreted as a personal diagnosis."]},{"article_id":"endometrial-cancer","title":"Endometrial cancer: the uterine lining, abnormal bleeding, biopsy, molecular findings, and care","words":667,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, detailed molecular-treatment comparisons and hereditary-risk surveillance evidence remain incomplete.","No bleeding cause, ultrasound threshold, tumor marker or molecular label is interpreted as a personal diagnosis."]},{"article_id":"bladder-cancer","title":"Bladder cancer: urothelial cells, blood in urine, muscle invasion, BCG, and follow-up","words":824,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.25","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, complete variant-histology evidence and current systemic-treatment comparisons remain incomplete.","No personal hematuria, tissue depth, grade or medicine suitability is interpreted."]},{"article_id":"kidney-cancer","title":"Kidney cancer: renal-cell types, drainage-system cancers, biopsy, kidney function, and care","words":906,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, current comprehensive systemic-treatment comparisons and full rare-family coverage remain incomplete.","No kidney mass, biopsy decision, filtration value or trial eligibility is interpreted for an individual."]},{"article_id":"thyroid-cancer","title":"Thyroid cancer: nodules, cell families, hormone tests, radioactive iodine, and screening","words":875,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, contemporary surveillance selection and complete advanced/rare-family treatment comparisons remain incomplete.","No nodule image, hormone result, RET finding or radioiodine eligibility is interpreted for an individual."]},{"article_id":"pancreatic-cancer","title":"Pancreatic cancer: ductal cancers, neuroendocrine tumors, cysts, markers, and care","words":947,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, current comprehensive treatment comparisons and detailed cyst/NET surveillance selection remain incomplete.","No marker, pancreatic lesion, new diabetes or familial-risk finding is interpreted as an individual diagnosis or monitoring schedule."]},{"article_id":"liver-cancer","title":"Liver cancer: primary tumors, metastases, liver function, AFP, and local treatments","words":950,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, inaccessible guidance-update appraisal and complete current systemic-treatment comparisons remain incomplete.","No liver lesion, AFP value, functional score or transplantation/surveillance eligibility is interpreted for an individual."]},{"article_id":"stomach-cancer","title":"Stomach cancer: gastric types, H. pylori, endoscopy, biomarkers, and eating after treatment","words":964,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, full inherited-risk and gastric-premalignancy surveillance guidance, and current comparative systemic-treatment synthesis remain incomplete.","No gastric biopsy, biomarker, antibiotic suitability, nutrition deficiency or screening eligibility is interpreted for an individual."]},{"article_id":"esophageal-cancer","title":"Esophageal cancer: squamous and glandular types, Barrett changes, swallowing, and care","words":922,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, detailed contemporary Barrett/dysplasia surveillance guidance and complete systemic-treatment comparisons remain incomplete.","No biopsy, swallowing symptom, stage, nutritional route or trial eligibility is interpreted for an individual."]},{"article_id":"testicular-cancer","title":"Testicular cancer: germ-cell types, markers, surgery, surveillance, and fertility","words":925,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review, contemporary rare-family taxonomy and complete treatment/late-effect comparison remain incomplete.","No lump, marker, fertility outcome, surveillance interval or trial eligibility is interpreted for an individual."]},{"article_id":"leukemia","title":"Leukemia: acute and chronic families, blood counts, molecular findings, observation, and residual disease","words":983,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent hematology review, full contemporary subtype-specific treatment comparisons and pediatric/rare-family evidence remain incomplete.","No blood count, marrow finding, molecular response, phase, MRD result or medicine stopping decision is interpreted for an individual."]},{"article_id":"lymphoma","title":"Lymphoma: Hodgkin and non-Hodgkin families, tissue diagnosis, stage, observation, and treatment outcomes","words":968,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent hematology review, complete modern taxonomy, subtype-specific systemic treatment and long-term comparative outcomes remain incomplete.","No node, scan, stage, tissue marker, observation eligibility or cellular-therapy decision is interpreted for an individual."]},{"article_id":"multiple-myeloma","title":"Multiple myeloma: plasma cells, MGUS, smoldering disease, protein tests, defining events, and care","words":959,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.26","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent myeloma review, complete risk-model comparison, full AQUILA correspondence/response appraisal and modern active-disease regimen comparisons remain incomplete.","No monoclonal protein, free-light-chain result, marrow percentage, lesion, stage or early-treatment eligibility is interpreted for an individual."]},{"article_id":"helicobacter-pylori","title":"H. pylori: stomach infection, ulcers, cancer risk, testing, eradication, and follow-up","words":876,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent gastroenterology review, full regional/population screening reconciliation, original guideline appraisal and probiotic-adjunct synthesis remain incomplete.","No infection result, regimen, medication interruption or household testing decision is selected for an individual."]},{"article_id":"gastritis","title":"Gastritis and gastropathy: lining inflammation, causes, atrophy, absorption, testing, and care","words":893,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent gastroenterology review, rare-cause evidence, complete dietary-outcome comparisons and reconciliation of all surveillance guidelines remain incomplete.","No biopsy, B12 result, infection test, medicine interruption or endoscopy interval is selected for an individual."]},{"article_id":"peptic-ulcer-disease","title":"Peptic ulcers: stomach and duodenal sores, causes, complications, testing, healing, and recurrence","words":728,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent gastroenterology review, original ulcer-healing/bleeding evidence synthesis and regional follow-up reconciliation remain incomplete.","An individual ulcer cause, medication plan, endoscopy indication or recurrence explanation requires clinical assessment."]},{"article_id":"gastroparesis","title":"Gastroparesis: delayed stomach emptying, diagnosis, nutrition, medicines, procedures, and uncertain evidence","words":901,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent motility-specialist review, full medication-induced delay/GLP-1 synthesis, complete procedure appraisal and regional medicine-access reconciliation remain incomplete.","No emptying result, dietary restriction, insulin adjustment, medicine plan or procedure eligibility is selected for an individual."]},{"article_id":"acute-pancreatitis","title":"Acute pancreatitis: sudden inflammation, causes, severity, tests, hospital care, feeding, and recurrence","words":785,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent pancreatic-specialist review, full fluid-trial eligibility/appraisal, necrosis management synthesis and regional guideline reconciliation remain incomplete.","No suspected episode, fluid amount, fasting duration, antibiotic indication or procedure timing is selected for an individual."]},{"article_id":"chronic-pancreatitis","title":"Chronic pancreatitis: scarring, variable symptoms, digestion, diabetes, enzymes, pain treatment, and follow-up","words":904,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent pancreatic-specialist review, full enzyme/formulation comparisons, pediatric/genetic/autoimmune synthesis and complete procedure appraisal remain incomplete.","A pain course, elastase result, insulin plan, enzyme dose, dietary restriction or surgical eligibility is not interpreted for an individual."]},{"article_id":"appendicitis","title":"Appendicitis: the appendix, urgent symptoms, diagnosis, complications, surgery, antibiotics, and recurrence","words":857,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent surgical review, full trial/guideline reconciliation, pediatric and pregnancy evidence synthesis and abscess-follow-up pathways remain incomplete.","No suspected episode, antibiotic course, imaging choice, surgical delay or eligibility for nonoperative care is selected for an individual."]},{"article_id":"hernias","title":"Hernias: locations, trapped tissue, strangulation, watchful waiting, repair, mesh, and population differences","words":943,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent surgical review, complete hiatus/paraesophageal and rare-hernia coverage, sex/age-specific observation synthesis and full technique/device comparisons remain incomplete.","No groin lump, reduction maneuver, lifting restriction, waiting eligibility or repair material is selected for an individual."]},{"article_id":"bowel-obstruction","title":"Bowel obstruction: mechanical blockage, ileus, pseudo-obstruction, causes, tests, urgency, and treatment evidence","words":925,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent surgical/motility review, full current guideline reconciliation, neonatal/pediatric and malignant-obstruction synthesis, and original contrast-trial appraisal remain incomplete.","No suspected blockage, oral-intake decision, contrast administration, medicine choice or surgery timing is selected for an individual."]},{"article_id":"bile-acid-diarrhea","title":"Bile acid diarrhea: recycling, malabsorption, primary overproduction, tests, treatment evidence, and uncertainty","words":1004,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.27","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent gastroenterology review, full current guideline/test-access reconciliation, long-term treatment and pediatric/pregnancy evidence, and full dietary appraisal remain incomplete.","No chronic diarrhea diagnosis, laboratory cutoff, SeHCAT preparation, binder prescription or personal food restriction is selected."]},{"article_id":"refractive-errors","title":"Refractive errors: myopia, hyperopia, astigmatism, presbyopia, correction, and myopia-control evidence","words":1067,"questions":8,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent eye-care review, complete contemporary myopia-control comparisons, prescription terminology, presbyopia medicines and long-term surgery outcomes remain incomplete.","No prescription strength, child’s progression, outdoor-time target, device, eye drop or operation is selected for an individual."]},{"article_id":"age-related-macular-degeneration","title":"Macular degeneration: central vision, dry and wet AMD, stages, supplements, injections, and evidence limits","words":1179,"questions":10,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent retinal review, full contemporary guideline/regulatory-access reconciliation, complete supplement and product comparisons, functional and long-term outcomes remain incomplete.","No retinal image, disease stage, supplement choice, injection eligibility, treatment interval or driving ability is interpreted for an individual."]},{"article_id":"diabetic-retinopathy","title":"Diabetic retinopathy: vessel damage, macular edema, stages, screening, pregnancy, treatments, and outcome evidence","words":1162,"questions":8,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent retinal/diabetes review, full contemporary guideline and drug comparisons, original-trial funding/limitations appraisal beyond abstracts and population-specific surveillance remain incomplete.","No retinal grade, image, personal screening interval, glucose target, fenofibrate eligibility, injection schedule or pregnancy plan is selected."]},{"article_id":"retinal-detachment","title":"Retinal detachment: tears, vitreous separation, three causes, repair options, and gas-bubble safety","words":977,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent retinal-surgery review, complete contemporary surgical comparisons, full PIVOT limitations and newer follow-up, and prognosis by macular status remain incomplete.","No symptom diagnosis, operation, head posture, travel date, anesthetic plan or personal visual prognosis is selected."]},{"article_id":"conjunctivitis","title":"Conjunctivitis: what pink eye is, infectious and allergic causes, antibiotics, hygiene, and warning signs","words":1008,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent eye-care review, complete contemporary diagnostics and drug comparisons, unusual pathogens, recurrent disease and institutional attendance policies remain incomplete.","No red-eye diagnosis, infectious period, antibiotic or steroid regimen, contact-lens clearance or newborn treatment is selected."]},{"article_id":"uveitis","title":"Uveitis: inflammation inside the eye, anatomical types, infectious causes, childhood screening, and treatment tradeoffs","words":1133,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent uveitis-specialist review, full contemporary infectious workup, complete comparative treatments, newer pediatric guidance and jurisdiction-specific access remain incomplete.","No diagnosis, inflammation grade, child screening interval, steroid route/taper, immune medicine or individual prognosis is selected."]},{"article_id":"amblyopia","title":"Amblyopia: visual development, lazy eye versus eye alignment, screening, patching, drops, and newer research","words":1145,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent pediatric eye-care review, full modern digital-device authorizations/comparisons, original animal-method appraisal, adult human treatments and long-term binocular outcomes remain incomplete.","No visual diagnosis, patch hours, atropine regimen, device, surgical plan, treatment taper or personal chance of recovery is selected."]},{"article_id":"hearing-loss","title":"Hearing loss: conductive and sensorineural types, sudden changes, testing, communication, devices, and cognition evidence","words":1284,"questions":10,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent audiology/ENT review, complete contemporary device comparisons and implant criteria, cause-specific treatments, language-access outcomes and longer-term cognition follow-up remain incomplete.","No diagnosis, hearing-test interpretation, device, medicine, implant eligibility, exposure limit or personal dementia-risk estimate is selected."]},{"article_id":"benign-paroxysmal-positional-vertigo","title":"Benign paroxysmal positional vertigo (BPPV): examination, Epley evidence, alternative causes, and rehabilitation","words":835,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent ENT/neurology review, full current vestibular-migraine treatments, persistent perceptual dizziness, modern BPPV comparisons and long-term rehabilitation outcomes remain incomplete.","No cause, home stroke test, maneuver side or sequence, medicine course, exercise dose, driving clearance or personal recurrence probability is selected."]},{"article_id":"menieres-disease","title":"Ménière’s disease: hearing and vertigo, diagnostic categories, hydrops, treatment goals, and uncertain evidence","words":1125,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.28","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent ENT review, full current practice-guideline and post-2023 trial reconciliation, intervention-specific long-term hearing/vertigo outcomes and pediatric/pregnancy evidence remain incomplete.","No Ménière’s diagnosis, sodium/fluid target, medicine dose, injection schedule, surgical choice, exercise plan, driving clearance or personal chance of remission is selected."]},{"article_id":"adrenal-insufficiency","title":"Adrenal insufficiency: Addison’s disease, pituitary and steroid-related forms, tests, replacement, and adrenal-fatigue claims","words":1218,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent endocrine review, complete current diagnostic-assay and formulation comparisons, long-term crisis/quality-of-life synthesis and full pediatric/pregnancy reconciliation remain incomplete.","No adrenal diagnosis, cortisol cutoff, steroid taper, replacement dose, emergency injection sequence, sodium target or personal recovery prediction is selected."]},{"article_id":"cushing-syndrome","title":"Cushing’s syndrome and disease: cortisol excess, different causes, testing, treatment, and recurrence","words":972,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete current comparative treatment appraisal, including surgical center effects, remains unfinished.","The 2026 regional consensus was inspected at abstract level, not reconciled recommendation by recommendation.","Rare hereditary, pediatric, pregnancy, cyclic and ectopic presentations need deeper dedicated coverage.","No qualified independent clinical review or individualized testing/medicine decision has been completed."]},{"article_id":"primary-aldosteronism","title":"Primary aldosteronism: aldosterone and renin, hypertension screening, adrenal subtypes, treatment, and outcome limits","words":948,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Familial disease, pregnancy, chronic kidney disease and cortisol co-secretion need deeper dedicated explanation.","New molecular imaging and the complete comparative surgery-versus-medical evidence have not been fully appraised.","Optimal renin-directed treatment when blood pressure is controlled remains uncertain in the cited guideline.","No qualified independent review, personal screening decision or medicine/dose recommendation is provided."]},{"article_id":"adrenal-incidentalomas","title":"Adrenal incidentalomas: unexpected masses, imaging and hormones, mild cortisol secretion, biopsy, and follow-up","words":956,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete appraisal of newer surgery trials and the full guideline’s conditional testing and imaging pathways remains unfinished.","Bilateral masses, hereditary syndromes, pregnancy, adrenal cancer and metastatic disease need deeper separate coverage.","Long-term event prevention and the best selection for surgery in MACS remain incompletely resolved.","No qualified independent review or personal decision about biopsy, surgery or surveillance has been completed."]},{"article_id":"pheochromocytoma-and-paraganglioma","title":"Pheochromocytoma and paraganglioma: locations, catecholamines, inherited risk, testing, treatment, and newer drug evidence","words":968,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current full diagnostic, genetic and surveillance guidance needs reconciliation beyond selected official passages.","Radiopharmaceutical, chemotherapy, local therapy and newer targeted-drug comparisons need separate detailed appraisal.","Pediatric, pregnancy, head/neck and individual hereditary-syndrome pathways need deeper dedicated coverage.","No qualified independent medical review or personalized testing, operation or medicine plan has been completed."]},{"article_id":"pituitary-tumors","title":"Pituitary tumors and incidentalomas: adenoma and PitNET names, size, hormone activity, vision, care, and surveillance","words":934,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full 2025 incidentaloma recommendations and exact surveillance pathways need further appraisal.","Aggressive/metastatic tumors, posterior-pituitary lesions, cysts and inherited syndromes need dedicated coverage.","Patient-reported outcomes, center-dependent procedural effects and long-term hormone recovery need deeper comparison.","No qualified independent review or personal MRI, hormone-test or treatment decision is provided."]},{"article_id":"prolactinoma-and-hyperprolactinemia","title":"Prolactinoma and hyperprolactinemia: hormone function, non-tumor causes, laboratory pitfalls, and treatment evidence","words":1040,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current comparative appraisal of modern surgery versus medical care remains incomplete.","Pregnancy, adolescents, menopause, psychiatric co-treatment and invasive/resistant disease need fuller dedicated assessment.","Macroprolactin methods and mixed active-hormone elevation need a laboratory-specific explanation beyond this introduction.","No qualified independent review or personal imaging, hormone-result or prescription interpretation is supplied."]},{"article_id":"acromegaly","title":"Acromegaly: growth hormone, IGF-1, diagnosis, complications, treatment goals, and newer oral-treatment evidence","words":1082,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full appraisal of the 2026 complication guidance and cancer-screening differences remains incomplete.","Active-comparator evidence, long-term patient outcomes, adolescent gigantism and inherited causes need deeper coverage.","Other drug classes, combinations, radiotherapy and procedural outcomes are introduced rather than exhaustively compared.","No qualified independent review or personal diagnosis, hormone target or treatment selection is supplied."]},{"article_id":"hypopituitarism","title":"Hypopituitarism: missing pituitary signals, central thyroid and adrenal deficiency, water balance, and replacement interactions","words":1168,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full correction text for the newer GH survey and a complete current comparative replacement appraisal remain unavailable or unfinished.","Congenital syndromes, immune-therapy hypophysitis, head-injury pathways and pediatric transition need dedicated articles.","Water-balance testing, formulation-specific desmopressin care, fertility and pregnancy need fuller assessment.","No qualified independent review or personal hormone interpretation, water plan or replacement prescription is supplied."]},{"article_id":"parathyroid-disorders","title":"Parathyroid disorders: PTH and calcium, primary versus secondary disease, low-PTH states, and treatment evidence","words":1224,"questions":8,"references":14,"depth_status":{"status":"expanded_explainer","edition":"3.29","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The entire original-trial versus regulatory response-rate difference is not yet reconciled; a dose-ceiling effect is verified.","Long-term renal, fracture, cardiovascular and mortality benefits need deeper current comparative appraisal.","Kidney-transplant disease, PTH resistance, inherited syndromes, hungry-bone syndrome and pregnancy need dedicated coverage.","No qualified independent review or personal calcium/PTH interpretation, supplementation plan or surgical decision is supplied."]},{"article_id":"congenital-adrenal-hyperplasia","title":"Congenital adrenal hyperplasia: inherited enzyme disorders, classic and nonclassic forms, screening, replacement, and newer treatment","words":1180,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Rare CAH enzyme defects need dedicated explanations; this page chiefly covers 21-hydroxylase deficiency.","Longer follow-up, final height, fertility, fractures, cardiovascular outcomes and comparative treatment burdens need fuller appraisal.","Prenatal and genital-surgery outcomes, diverse lived experiences and jurisdictional differences need deeper review.","No qualified independent review, individual genetic/laboratory interpretation or hormone-adjustment plan is supplied."]},{"article_id":"multiple-endocrine-neoplasia-type-1","title":"Multiple endocrine neoplasia type 1: inherited tumor risk, hormone effects, genetic testing, surveillance, and treatment uncertainty","words":1093,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary surveillance and operative-threshold reconciliation across the two 2025 documents remains incomplete.","The international guideline correction body was inaccessible; no corrected table or unchanged-content assumption is supplied.","Breast risk, thymic/bronchial tumors, childhood care, pregnancy and mutation-negative phenocopies need dedicated appraisal.","No qualified independent review or personal genetic, imaging or surgical decision is supplied."]},{"article_id":"multiple-endocrine-neoplasia-type-2","title":"Multiple endocrine neoplasia type 2: RET inheritance, MEN2A and MEN2B, medullary thyroid cancer, prevention, and targeted treatment","words":1139,"questions":8,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary variant-specific thyroidectomy timing and long-term surveillance differences need fuller expert appraisal.","Inherited versus sporadic trial subgroups, overall survival and newer follow-up need dedicated comparative review.","Adrenal-sparing surgery, pediatric drug evidence, pregnancy and quality-of-life outcomes need deeper coverage.","No qualified independent review, personal prognosis or genetic, surgical or drug-treatment plan is supplied."]},{"article_id":"hypophysitis","title":"Hypophysitis: pituitary inflammation, autoimmune and treatment-related forms, hormone loss, imaging, and treatment evidence","words":845,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Larger and longer randomized comparisons, subtype-specific care and hormone recovery remain incompletely resolved.","Pediatric, infectious and systemic IgG4-related disease need dedicated appraisal.","No qualified independent review, personal diagnostic interpretation or cancer-treatment decision is supplied."]},{"article_id":"sheehan-syndrome","title":"Sheehan syndrome: postpartum pituitary injury, immediate and delayed symptoms, hormone assessment, replacement, and recovery questions","words":892,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Population incidence, screening after hemorrhage and long-term patient-important treatment effects need deeper appraisal.","Fertility, subsequent pregnancy, prolactin deficiency and rarer nonclassic injury presentations need dedicated coverage.","No qualified independent review or personal postpartum diagnosis, hormone interpretation or prescription plan is supplied."]},{"article_id":"growth-hormone-deficiency","title":"Growth-hormone deficiency: childhood growth, adult metabolic effects, diagnostic testing, replacement, and weekly-treatment evidence","words":962,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The linked foresiGHt correction body was inaccessible; corrected numerical result reconciliation is pending.","Contemporary diagnostic thresholds, pediatric final-height effects and long-term weekly-product comparisons need fuller expert appraisal.","No qualified independent review, personal testing interpretation or replacement/enhancement plan is supplied."]},{"article_id":"arginine-vasopressin-deficiency","title":"Arginine vasopressin deficiency: central diabetes insipidus, thirst and urine, copeptin testing, desmopressin, and fluid safety","words":927,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Pediatric, pregnancy-associated and adipsic disease need fuller dedicated appraisal.","Local assay availability, partial forms and contemporary diagnostic algorithms need qualified comparison.","No qualified independent review, home deprivation procedure or personal fluid/desmopressin plan is supplied."]},{"article_id":"arginine-vasopressin-resistance","title":"Arginine vasopressin resistance: nephrogenic diabetes insipidus, inherited and acquired causes, kidney signaling, nutrition, and treatment evidence","words":899,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term comparative treatment and patient-important renal/quality-of-life outcomes need deeper appraisal.","Partial resistance, pregnancy, acquired causes and emerging gene-targeted approaches require dedicated coverage.","No qualified independent review, personal genetic interpretation or fluid, diet or medication plan is supplied."]},{"article_id":"precocious-puberty","title":"Precocious puberty: early development, central and peripheral causes, normal variants, assessment, and treatment evidence","words":1046,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Age-specific causal height benefit, long-term psychological outcomes and boys’ comparative evidence need deeper appraisal.","Peripheral disease, hormone exposure, environmental hypotheses and syndrome-specific care need dedicated explanations.","No qualified independent review, personal diagnosis or puberty-treatment schedule is supplied."]},{"article_id":"delayed-puberty","title":"Delayed puberty: self-limited delay, chronic illness, hormone deficiency, assessment, and treatment goals","words":1011,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.30","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Newer diagnostic accuracy studies and cause-specific treatment comparisons need deeper appraisal.","Turner/Klinefelter syndromes, stalled progression, fertility pathways and diverse developmental/sex-trait contexts need dedicated coverage.","No qualified independent review, adolescent diagnosis, hormone interpretation or induction regimen is supplied."]},{"article_id":"peripheral-arterial-disease","title":"Peripheral artery disease: arterial narrowing, walking symptoms, limb-threatening disease, tests, exercise, and procedural evidence","words":1002,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Device-specific safety, modern drug comparisons and complete procedural-subgroup reconciliation need deeper appraisal.","Nonatherosclerotic arterial disease, acute limb ischemia and ulcer/diabetic-foot pathways need dedicated explanations.","No qualified independent review, personal ABI interpretation, walking prescription or procedure selection is supplied."]},{"article_id":"heart-valve-disease","title":"Heart valve disease: stenosis, regurgitation, prolapse, assessment, repair or replacement, and early-intervention uncertainty","words":1070,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual valve lesions, congenital forms, pregnancy, infection and prosthesis durability need dedicated explanations.","Full reconciliation of early-intervention trials, guideline differences and current device-specific safety remains incomplete.","No qualified independent review, personal echo interpretation, procedure choice or anticoagulation plan is supplied."]},{"article_id":"cardiomyopathy","title":"Cardiomyopathy: heart muscle phenotypes, inherited disease, assessment, recovery, and targeted treatment evidence","words":998,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual inherited syndromes, arrhythmia prevention, sports eligibility, peripartum disease and amyloid pathways need dedicated explanations.","Long-term comparative myosin-inhibitor outcomes and reliable predictors of sustained DCM remission need deeper appraisal.","No qualified independent review, personal genetic interpretation, exercise clearance or medication-withdrawal plan is supplied."]},{"article_id":"myocarditis","title":"Myocarditis: heart muscle inflammation, causes, diagnostic uncertainty, treatment differences, and recovery","words":886,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Treatment effects for individual histological/infectious causes and long-term prognosis require deeper study-level appraisal.","Absolute vaccine/infection risks by product, age, sex and dose need a dedicated, current comparison.","No qualified independent review, individual diagnosis, medication regimen or exercise clearance is supplied."]},{"article_id":"pericarditis","title":"Pericarditis: the heart’s surrounding sac, acute and recurrent inflammation, effusion, and treatment evidence","words":929,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Constrictive pericarditis, malignancy/infection-specific care and procedural effusion management need dedicated explanations.","Optimal duration, withdrawal strategy and head-to-head immune-therapy comparisons need deeper appraisal.","No qualified independent review, individual chest-pain diagnosis, dosing regimen or activity clearance is supplied."]},{"article_id":"aortic-aneurysm","title":"Aortic aneurysm: abdominal and thoracic enlargement, screening, surveillance, and repair tradeoffs","words":1033,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Heritable thoracic syndromes, segment-specific thresholds, women’s screening evidence and pregnancy need deeper dedicated coverage.","Modern-device durability, endoleak management and current guideline reconciliation remain incomplete.","No qualified independent review, personal scan interpretation, screening eligibility decision or repair threshold is supplied."]},{"article_id":"aortic-dissection","title":"Aortic dissection: wall-layer separation, type A and B, emergency assessment, treatment, and long-term follow-up","words":881,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Intramural hematoma, penetrating ulcers, heritable syndromes and pregnancy-specific pathways need dedicated coverage.","Modern trials, device-era differences and complete long-term benefit/risk reconciliation remain incomplete.","No qualified independent review, emergency diagnosis, home medication adjustment or personal procedure choice is supplied."]},{"article_id":"pulmonary-hypertension","title":"Pulmonary hypertension: five cause groups, functional classes, diagnostic tests, and treatment-specific evidence","words":961,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary PAH trial extraction, numerical precision and drug-combination comparisons need deeper appraisal.","CTEPH surgery/balloon pathways, pregnancy, inherited PAH and exercise rehabilitation need dedicated coverage.","No qualified independent review, personal hemodynamic classification, drug eligibility or dosing plan is supplied."]},{"article_id":"orthostatic-hypotension","title":"Orthostatic hypotension: standing-related pressure drops, timing patterns, causes, assessment, and management tradeoffs","words":850,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["POTS, vasovagal syncope, autonomic syndromes and validated monitoring protocols need dedicated explanations.","Comparative treatment efficacy, falls prevention and optimal management of supine hypertension need deeper appraisal.","No qualified independent review, personal standing-test diagnosis, salt/fluid target or medication adjustment is supplied."]},{"article_id":"varicose-veins","title":"Varicose veins: venous reflux, symptoms, duplex assessment, compression uncertainty, and procedural evidence","words":1074,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.31","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Venous-insufficiency severity staging, arterial suitability for compression, recurrence and modern nonthermal procedures need dedicated coverage.","Complete EVRA methods/harms appraisal and newer comparative treatment evidence remain outstanding.","No qualified independent review, personal wound diagnosis, stocking pressure or procedural selection is supplied."]},{"article_id":"low-back-pain","title":"Low back pain: specific and nonspecific causes, duration, scans, rehabilitation, and changing guidance","words":1075,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full NICE surveillance-rationale appraisal and cross-guideline reconciliation remain incomplete.","Inflammatory spine disease, individual structural causes and contemporary exercise comparisons need dedicated coverage.","Qualified review, personal diagnosis, imaging interpretation and exercise or medicine prescriptions are not supplied."]},{"article_id":"neck-pain","title":"Neck pain: nonspecific pain, nerve-root and spinal-cord problems, whiplash, exercise, and manipulation uncertainty","words":1046,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Dedicated cervical myelopathy, radiculopathy and post-trauma pathways need fuller coverage.","Contemporary exercise comparisons and reliable serious-manual-treatment risk estimates remain incompletely appraised.","Qualified review, personal imaging decisions, exercise clearance and manipulation recommendations are not supplied."]},{"article_id":"sciatica","title":"Sciatica: radiating nerve pain, disc herniation, assessment, medicines, injections, and surgery evidence","words":1099,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current NICE-detail reconciliation, contemporary nonsurgical comparisons and precise serious-procedure risks remain incomplete.","Dedicated disc disease, spinal stenosis, cauda equina and other leg-pain differentials need deeper coverage.","Qualified review, personal diagnosis, medicine changes, injection selection and surgical decisions are not supplied."]},{"article_id":"tendinopathy","title":"Tendinopathy: tendon pain, terminology, loading, tears, regional differences, and injection evidence","words":1085,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full 2024 Achilles recommendations, contemporary regional loading comparisons and complete GRASP correction/harms appraisal remain outstanding.","Individual tendon sites, rupture pathways, systemic/inflammatory contributions and formulation-specific injection evidence need fuller coverage.","Qualified review, personal diagnosis, loading prescriptions, pain-monitoring targets and return-to-sport clearance are not supplied."]},{"article_id":"bursitis","title":"Bursitis: cushioning sacs, superficial and deep locations, infection, aspiration, and treatment uncertainty","words":927,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary bursa-specific treatment comparisons, recurrence and full septic-bursitis pathways need deeper appraisal.","Greater-trochanteric pain syndrome, tendon/bursa overlap and regional differential diagnoses need dedicated explanations.","Qualified review, personal infection diagnosis, self-aspiration, medicine plans and procedure selection are not supplied."]},{"article_id":"plantar-fasciitis","title":"Plantar fasciitis: fascia and heel spurs, first-step pain, rehabilitation, orthoses, injections, and evidence limits","words":1289,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Newer injection, shock-wave, orthosis and rehabilitation comparisons require deeper appraisal.","Heel fat-pad pain, regional neuropathy, inflammatory enthesitis and foot-specific bone-stress pathways need dedicated coverage.","Qualified review, personal diagnosis, exercise dosing, injection selection and surgical decisions are not supplied."]},{"article_id":"carpal-tunnel-syndrome","title":"Carpal tunnel syndrome: median-nerve compression, symptom distribution, diagnostic guidance, splints, injections, and surgery","words":995,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full cross-guideline diagnostic reconciliation and complete surgical/injection harms appraisal remain outstanding.","Other hand neuropathies, electrodiagnostic interpretation, workplace exposures and recurrent postoperative symptoms need dedicated coverage.","Qualified review, personal diagnosis, self-scoring clearance, injection decisions and surgery selection are not supplied."]},{"article_id":"fractures","title":"Fractures: broken-bone terminology, open and stress injuries, alignment, healing, fixation, and rehabilitation evidence","words":1011,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Bone-specific fracture pathways, pediatric injuries, fragility-fracture prevention and full open-fracture care need dedicated coverage.","Complete WAX eligibility, protocol, funding and longer-term outcome appraisal remain outstanding.","Qualified review, personal imaging interpretation, cast adjustment and weight-bearing clearance are not supplied."]},{"article_id":"sprains","title":"Sprains: ligament injury, grades, ankle patterns, fracture assessment, support, rehabilitation, and reinjury evidence","words":816,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Knee, wrist, high-ankle and individual ligament pathways need dedicated explanations.","Newer recurrence comparisons, validated return-to-sport criteria and full review-method appraisal remain outstanding.","Qualified review, personal injury grading, brace duration and return-to-sport clearance are not supplied."]},{"article_id":"muscle-strains","title":"Muscle strains: muscle and tendon injury, severity, avulsions, rehabilitation timing, PRP, and return-to-activity uncertainty","words":908,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.32","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Newer rehabilitation, return-to-activity and PRP comparisons need deeper appraisal.","Other muscle locations, injury grading systems, complete HIT follow-up and pediatric avulsion pathways need dedicated coverage.","Qualified review, personal imaging diagnosis, exercise dosing and return-to-sport clearance are not supplied."]},{"article_id":"fibromyalgia","title":"Fibromyalgia: widespread pain, diagnosis, care, exercise evidence, and immune-mechanism uncertainty","words":875,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary exercise, psychological, drug and complementary comparisons need fuller systematic appraisal.","Replication and clinical relevance of immune findings, subgroup identification and validated biomarkers remain open.","Qualified review, individual diagnosis, medication selection and a personal exercise program are not supplied."]},{"article_id":"systemic-lupus-erythematosus","title":"Systemic lupus erythematosus: autoimmune disease, organ patterns, antibody tests, treatment goals, and trial outcomes","words":816,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full 2025 recommendation/evidence-table appraisal and organ-specific pathways, including nephritis, need deeper work.","Comparative drug effectiveness, long-term harms, pregnancy pathways and patient-important outcomes remain incompletely synthesized.","Qualified review, individual ANA interpretation, flare assessment and medication selection are not supplied."]},{"article_id":"sjogren-disease","title":"Sjögren disease: dryness, wider autoimmune effects, antibody limitations, dental care, and systemic-treatment evidence","words":822,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary guideline appraisal, systemic organ pathways and newer randomized therapies need additional work.","Long-term patient-important outcomes, pediatric evidence, fatigue management and lymphoma risk stratification remain incompletely synthesized.","Qualified review, individual antibody interpretation, biopsy decisions and medication selection are not supplied."]},{"article_id":"systemic-sclerosis","title":"Systemic sclerosis: localized versus systemic scleroderma, skin patterns, vascular disease, lung outcomes, and care","words":897,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current guideline appraisal, lung/cardiovascular/kidney pathways and comparative treatment outcomes need expansion.","Localized morphea, pediatric disease, capillary findings and newer long-term trial evidence need dedicated coverage.","Qualified review, personal subtype diagnosis, medication choice and organ-monitoring schedules are not supplied."]},{"article_id":"axial-spondyloarthritis","title":"Axial spondyloarthritis: radiographic and non-radiographic disease, inflammatory back pain, testing limits, and care","words":788,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary comparative drug, exercise, imaging and structural-progression evidence needs deeper appraisal.","Pediatric disease, MRI specificity, sex-related diagnostic delay and fracture pathways need fuller coverage.","Qualified review, individual diagnosis, MRI interpretation and a personal treatment or exercise program are not supplied."]},{"article_id":"psoriatic-arthritis","title":"Psoriatic arthritis: joints, entheses, dactylitis, skin and nails, diagnosis, treatment domains, and comparison evidence","words":854,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary domain-specific comparisons, guideline evidence tables and GRAPPA correction appraisal need further work.","Axial PsA, juvenile disease, prevention after skin psoriasis and long-term comparative harms need fuller coverage.","Qualified review, personal diagnosis, drug sequencing and a personal rehabilitation program are not supplied."]},{"article_id":"polymyalgia-rheumatica","title":"Polymyalgia rheumatica: shoulder and hip stiffness, diagnostic mimics, steroid exposure, relapse, and newer evidence","words":877,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full July 2026 EULAR recommendation/supporting-review appraisal and contemporary drug comparisons remain outstanding.","Diagnostic mimics, frailty, exercise, checkpoint-inhibitor syndromes and long-term treatment harms need deeper coverage.","Qualified review, personal diagnosis, medication initiation and a personal glucocorticoid taper are not supplied."]},{"article_id":"giant-cell-arteritis","title":"Giant-cell arteritis: urgent visual risk, artery involvement, diagnostic pathways, steroid-sparing trials, and newer guidance","words":858,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full July 2026 management and comparative imaging evidence appraisal, including local implementation, remains outstanding.","Longer-term comparative harms, visual outcomes, large-vessel monitoring and newer direct comparisons need fuller coverage.","Qualified review, personal diagnosis, urgent-care triage and medication/taper selection are not supplied."]},{"article_id":"reactive-arthritis","title":"Reactive arthritis: infection triggers, wider symptoms, diagnostic questions, antibiotic evidence, and recovery","words":851,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary organism-specific antibiotic comparisons, review/trial overlap and complete study appraisal remain outstanding.","Chronic disease, pediatric patterns, extra-articular care and newer long-term outcomes need deeper coverage.","Qualified review, personal infection/joint diagnosis, test interpretation and antibiotic selection are not supplied."]},{"article_id":"septic-arthritis","title":"Septic arthritis: urgent joint infection, native versus prosthetic joints, testing limits, drainage, and antibiotic evidence","words":816,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.33","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current diagnostic-test accuracy, review erratum, complete non-inferiority methods and larger-joint comparisons need appraisal.","Pediatric, gonococcal, fungal, tuberculosis and prosthetic-infection pathways require dedicated explanations.","Qualified review, personal diagnosis, urgent-care triage, procedure selection and antibiotic choice/duration are not supplied."]},{"article_id":"essential-tremor","title":"Essential tremor: action versus rest tremor, assessment, daily function, procedures, and the changed 2026 medication evidence","words":855,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full 2026 study-level appraisal, contemporary genetics and comparative procedural evidence remain outstanding.","Head/voice tremor, ET-plus controversies, device evidence and long-term functional outcomes need dedicated coverage.","Qualified review, personal tremor diagnosis, medicine choice and procedure selection are not supplied."]},{"article_id":"dystonia","title":"Dystonia: muscle contractions, body distributions, causes, focal injections, deep-brain stimulation, and evidence limits","words":836,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Modern cause-specific treatment, repeated injection cycles and complete surgical harms/funding need further appraisal.","Pediatric/genetic disease, functional dystonia, rehabilitation comparisons and individual regional pathways need dedicated coverage.","Qualified review, personal movement diagnosis, genetic interpretation and injection or surgery selection are not supplied."]},{"article_id":"bells-palsy","title":"Bell’s palsy: facial-nerve weakness, urgent alternatives, eye protection, early treatment, recovery, and antiviral uncertainty","words":850,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current pediatric trials, facial rehabilitation and complete review/trial overlap need fuller appraisal.","Persistent synkinesis, alternative facial-nerve diagnoses, prognostic testing and procedure comparisons need dedicated coverage.","Qualified review, personal facial-weakness diagnosis, medicine selection and eye-treatment instructions are not supplied."]},{"article_id":"myasthenia-gravis","title":"Myasthenia gravis: fatigable weakness, ocular versus generalized disease, testing, crisis, and treatment evidence","words":775,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full 2025 recommendations, newer comparative therapies, seronegative/ocular evidence and pediatric care need appraisal.","Complete corrected MGTX data, trial overlap, pregnancy and long-term targeted-therapy harms need deeper coverage.","Qualified review, personal diagnosis, crisis assessment and medicine/surgery selection are not supplied."]},{"article_id":"guillain-barre-syndrome","title":"Guillain–Barré syndrome: acute immune nerve injury, urgent monitoring, recovery, treatment, and vaccine-risk context","words":756,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full variant definitions, diagnostic accuracy, severity/timing recommendations and newer immune treatments need appraisal.","Complete recovery cohorts, pediatric care, trial overlap and product-specific contemporary vaccine estimates need deeper coverage.","Qualified review, personal diagnosis, emergency assessment and immune-treatment or vaccine selection are not supplied."]},{"article_id":"amyotrophic-lateral-sclerosis","title":"ALS: motor neurons, diagnosis, genetics, daily support, and what newer treatment results actually show","words":858,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current prescribing information, confirmatory trials, missing-data methods and comparative disease-modifying care need appraisal.","Broader MND subtypes, genetic variant interpretation, presymptomatic counseling and dedicated respiratory/end-of-life resources need expansion.","Qualified review, personal diagnosis, prognosis, genetic interpretation and treatment selection are not supplied."]},{"article_id":"huntingtons-disease","title":"Huntington’s disease: movement, thinking, inheritance, testing choices, care, and disease-modification claims","words":847,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Newer gene-targeting programs, current trial status, comparative symptom medicines and full protocol appraisal remain outstanding.","Juvenile care, reproductive options, advanced feeding/communication support and local predictive-testing pathways need expansion.","Qualified review, personal genetic interpretation, onset/prognosis prediction and treatment selection are not supplied."]},{"article_id":"narcolepsy","title":"Narcolepsy: sleepiness, cataplexy, type 1 versus type 2, specialist testing, care, and orexin research","words":843,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current phase-three/regulatory orexin evidence, full study protocols, pediatric testing and comparative symptom outcomes need appraisal.","Type-2 diagnostic uncertainty, long-term harms, pregnancy, school/work support and local driving pathways need deeper coverage.","Qualified review, personal diagnosis, test preparation, medication selection and driving clearance are not supplied."]},{"article_id":"idiopathic-hypersomnia","title":"Idiopathic hypersomnia: sleepiness versus fatigue, difficult awakening, assessment, and treatment-study limits","words":977,"questions":11,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full diagnostic criteria, repeat-test reliability, long-sleep cohorts and current comparative/regulatory evidence need appraisal.","Study overlap, current prescribing details, long-term harms, comorbidities and practical work/school support need expansion.","Qualified review, personal diagnosis, sleep-test preparation, treatment choice and driving clearance are not supplied."]},{"article_id":"trigeminal-neuralgia","title":"Trigeminal neuralgia: shock-like facial pain, classification, MRI limits, medicines, and procedure trade-offs","words":806,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.34","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary drug trials, MRI accuracy, classification boundaries and secondary-disease procedures need appraisal.","Complete network assumptions, study overlap, long-term recurrence/harms, correspondence and facial-pain alternatives need expansion.","Qualified review, personal facial-pain diagnosis, test interpretation and medicine/procedure selection are not supplied."]},{"article_id":"exocrine-pancreatic-insufficiency","title":"Pancreatic enzyme insufficiency: digestion, EPI versus diabetes, assessment, replacement enzymes, and nutrition","words":770,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full diagnostic thresholds, watery-sample accuracy, mild disease and complete comparative PERT evidence need appraisal.","Condition-specific postoperative care, pediatric/genetic causes, formulation differences and contemporary study overlap need deeper coverage.","Qualified review, personal diagnosis, laboratory interpretation, enzyme dosing and nutrition prescriptions are not supplied."]},{"article_id":"cholecystitis","title":"Cholecystitis: gallbladder inflammation, stones versus no stones, urgent care, drainage, and surgery evidence","words":734,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary imaging accuracy, guideline criteria, trial flow and newer drainage techniques need appraisal.","Acalculous disease, critically ill/inoperable populations, antibiotic strategies and long-term postoperative outcomes need deeper coverage.","Qualified review, personal diagnosis, emergency triage and antibiotic/procedure selection are not supplied."]},{"article_id":"hiatus-hernia","title":"Hiatus hernia: sliding and paraesophageal types, reflux, investigation, surgery, and uncertainty about mesh","words":709,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The linked review correction, full contemporary trial eligibility, funding, attrition and mesh-specific harms need verification.","Complete emergency, giant-hernia, recurrence and asymptomatic decision evidence needs expansion.","Qualified review and personal test, medicine or surgical selection are not supplied."]},{"article_id":"lactose-intolerance","title":"Lactose intolerance: milk sugar, lactase, malabsorption versus symptoms, allergy, and keeping a nutritious diet","words":1173,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary controlled lactase, fermented-food, prebiotic and adaptation studies need full appraisal.","Breath-test accuracy, symptom reproducibility and congenital/pediatric nutrition need expansion.","Qualified review, personal diagnosis, allergy assessment and dietary/supplement prescriptions are not supplied."]},{"article_id":"anal-fissure","title":"Anal fissure: a tear versus hemorrhoids, acute and chronic disease, stool care, medicines, surgery, and continence","words":902,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary botulinum, tailored sphincterotomy, flap and long-term continence trials require complete appraisal.","Atypical fissures, obstetric injury, pediatric disease, treatment interactions and trial overlap need expansion.","Qualified review, personal bleeding diagnosis and medicine or procedural selection are not supplied."]},{"article_id":"small-intestinal-bacterial-overgrowth","title":"SIBO: classical malabsorption, breath testing, IBS controversy, methanogen terminology, and treatment uncertainty","words":886,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary diagnostic accuracy, invasive sampling, transit measurement and methane-specific treatment need complete appraisal.","Full randomized antibiotic, recurrence, dietary, probiotic and non-antibiotic comparisons remain outstanding.","Qualified review, personal breath-test interpretation and antimicrobial or restrictive-diet protocols are not supplied."]},{"article_id":"microscopic-colitis","title":"Microscopic colitis: watery diarrhea, normal-looking colonoscopy, biopsy subtypes, budesonide, relapse, and diet limits","words":774,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary induction/maintenance trials, complete sponsor roles, adverse effects and responder selection need appraisal.","Incomplete histology, biopsy sampling, overlapping bile-acid diarrhea, refractory therapy and pediatric disease need expansion.","Qualified review, personal diarrhea diagnosis and medicine/diet prescriptions are not supplied."]},{"article_id":"short-bowel-syndrome","title":"Short bowel syndrome: remaining anatomy, malabsorption, adaptation, intestinal failure, nutrition support, and teduglutide","words":818,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current long-term and pediatric trials, support independence, quality of life and complete sponsor roles require appraisal.","Anatomy-specific fluid physiology, catheter safety, reconstruction, transplant criteria and rare complications need expansion.","Qualified review and personal nutrition, fluid, catheter or medicine instructions are not supplied."]},{"article_id":"dumping-syndrome","title":"Dumping syndrome: early fluid shifts, late low glucose, postoperative anatomy, nutrition, and conflicting test guidance","words":728,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary diagnostic accuracy, overlap between late dumping/PBH, emergency hypoglycemia care and CGM-management trials need expansion.","Full comparative drug, diet and revisional-surgery evidence, sponsor roles and rare nonsurgical populations remain outstanding.","Qualified review, personal glucose diagnosis and diet, medication or surgical prescriptions are not supplied."]},{"article_id":"barretts-esophagus","title":"Barrett’s esophagus: metaplasia versus dysplasia, biopsy confirmation, surveillance, eradication therapy, and cancer-risk context","words":848,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.35","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete contemporary surveillance effectiveness, absolute-risk strata, expert reclassification and trial funding/correspondence require appraisal.","Indefinite dysplasia, recurrence after eradication, early cancer, emerging sampling devices and long-term mortality need expansion.","Qualified review, personal biopsy interpretation and endoscopy/medicine/procedure schedules are not supplied."]},{"article_id":"thiamin","title":"Thiamin (vitamin B1): food, deficiency, beriberi, Wernicke–Korsakoff disease, testing, and supplement claims","words":902,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete contemporary disease-specific supplementation and dose evidence, funding, correspondence and safety appraisal remain outstanding.","Refeeding, pregnancy vomiting, infant deficiency and specialist emergency protocols require dedicated coverage.","Qualified review, personal deficiency diagnosis and replacement regimens are not supplied."]},{"article_id":"riboflavin","title":"Riboflavin (vitamin B2): food, deficiency, intake estimates, migraine research, and rare transporter disorders","words":899,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current migraine guideline recommendations, pediatric results and full trial-level benefit/safety and sponsorship appraisal remain outstanding.","Rare transporter syndromes, biomarker validation and special nutritional populations need dedicated coverage.","Qualified review, personal deficiency diagnosis and supplement or migraine regimens are not supplied."]},{"article_id":"niacin","title":"Niacin (vitamin B3): forms, food, pellagra, flushing, cholesterol trials, and NAD-related claims","words":934,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current lipid guidelines, newer B3 derivatives, skin-cancer-specific nicotinamide trials and full sponsor/correspondence appraisal need expansion.","NAD-targeted products, laboratory claims and long-term high-dose safety require product-specific articles and evidence.","Qualified review, personal nutrient diagnosis and supplement or lipid-treatment regimens are not supplied."]},{"article_id":"pantothenic-acid","title":"Pantothenic acid (vitamin B5): food, adequate-intake estimates, deficiency, pantethine, acne research, and evidence limits","words":869,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full ingredient, sponsor-role and bias appraisal, contemporary acne replication and event-based pantethine evidence remain outstanding.","Specialist PKAN treatment trials, contemporary nutrient-status validation and special nutritional populations need expansion.","Qualified review, personal deficiency diagnosis and acne, lipid or supplement regimens are not supplied."]},{"article_id":"vitamin-k","title":"Vitamin K: K1 and K2, food, warfarin, newborn prevention, bone studies, and calcification claims","words":843,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current K2 bone/cardiovascular evidence, sponsor roles, trial correspondence and subsequent replication require appraisal.","Malabsorption, medicine-specific interactions, neonatal oral regimens across jurisdictions and emerging formulations need expansion.","Qualified review, personal anticoagulant changes and infant/adult vitamin K dosing protocols are not supplied."]},{"article_id":"choline","title":"Choline: nutrient forms, food, liver function, intake estimates, infant cognition research, and TMAO uncertainty","words":851,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current pregnancy/cognition guidance, later follow-up, clinical liver-treatment trials and full sponsor/participant-level appraisal remain outstanding.","TMAO causality, citicoline/alpha-GPC-specific evidence, formulation equivalence and long-term safety need dedicated expansion.","Qualified review, personal deficiency or cognitive diagnosis and pregnancy/adult supplement regimens are not supplied."]},{"article_id":"copper","title":"Copper: essential functions, food, deficiency, zinc interactions, testing, excess exposure, Menkes syndrome, and Wilson disease","words":927,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full amended safety/exposure tables, current specialist diagnostic/treatment guidance and disease-specific supplementation studies need appraisal.","Neurological recovery after deficiency, bariatric/nutrition-support settings and environmental copper exposure need expansion.","Qualified review, personal laboratory interpretation and copper/zinc replacement or Wilson/Menkes treatment regimens are not supplied."]},{"article_id":"phosphorus","title":"Phosphorus and phosphate: food, absorption, blood levels, kidney disease, additives, and intake uncertainty","words":788,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full patient-important renal diet/additive outcomes, nutritional tradeoffs, sponsor roles and current guideline updates need appraisal.","Severe low phosphate, refeeding, genetic phosphate wasting, binders and medicine-related phosphate injury need dedicated expansion.","Qualified review, personal phosphate interpretation and supplement, diet or binder prescriptions are not supplied."]},{"article_id":"chromium","title":"Chromium: disputed essentiality, chromium III versus VI, old intake tables, diabetes guidance, weight-loss evidence, and supplement safety","words":848,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary diabetes/weight/PCOS trial appraisal, medicine-specific interactions, sponsor roles and long-term safety remain outstanding.","The original 2005 FDA qualified-claim letter was blocked in its archive and was not independently appraised.","Qualified review, personal chromium deficiency diagnosis and diabetes, weight or supplement regimens are not supplied."]},{"article_id":"molybdenum","title":"Molybdenum: enzyme cofactors, food, rare deficiency, sulfite-oxidase disorders, newer type-A treatment, and supplement claims","words":883,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.36","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current subtype-specific specialist guidance, full integrated-review/label appraisal, newer gene classification and long-term treated outcomes remain outstanding.","Original acquired-deficiency case, exposure thresholds and trials of common sulfite-sensitivity or detox claims need separate appraisal.","Qualified review, personal genetic/nutritional diagnosis and molybdenum or fosdenopterin treatment regimens are not supplied."]},{"article_id":"rhodiola","title":"Rhodiola: plant identity, adaptogen claims, fatigue, exercise, depression trials, traditional registration, and safety uncertainty","words":916,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full revised EMA assessment, newer endurance-trial quality, effect precision, sponsor roles and publication overlap need appraisal.","Other Rhodiola species, altitude, chronic illness, burnout, pregnancy and long-term outcomes require separate expansion.","Qualified review, personal fatigue/depression diagnosis and supplement or antidepressant regimens are not supplied."]},{"article_id":"echinacea","title":"Echinacea: species, roots versus aerial parts, cold prevention versus treatment, differing study results, allergy, and product-specific evidence","words":911,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Newer respiratory trials, preparation equivalence, full funding/precision data and current review reconciliation require appraisal.","Pediatric recurrent infections, immunosuppression, pregnancy, allergy subgroups and skin indications need further expansion.","Qualified review, personal infection/allergy diagnosis and echinacea treatment schedules are not supplied."]},{"article_id":"ginkgo","title":"Ginkgo: leaf extracts versus seeds, dementia prevention versus symptoms, the 2026 review, European medicinal scope, and bleeding precautions","words":878,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.37","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete updated review tables, displayed-estimate reconciliation, trial overlap and contemporary licensing comparisons need appraisal.","Healthy-younger-person cognition, longer-term dementia treatment, interaction risks and all extract specifications require expansion.","Qualified review, personal cognitive diagnosis and ginkgo or anticoagulant regimens are not supplied."]},{"article_id":"st-johns-wort","title":"St John’s wort: depression evidence, extract differences, conflicting trials, enzyme induction, serious medicine interactions, and long-term uncertainty","words":820,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.37","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary guideline and trial reconciliation, extract equivalence, rare harms, full sponsor roles and severe/long-term depression require appraisal.","Individual low-hyperforin preparations, starting/stopping interaction dynamics, other indications and reproductive contexts need further expansion.","Qualified review, personal psychiatric diagnosis and supplement or medicine-switching regimens are not supplied."]},{"article_id":"elderberry","title":"Elderberry: berry preparations, cold prevention versus duration, conflicting influenza trials, cytokine claims, raw-plant toxicity, and COVID marketing","words":977,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary respiratory trials, complete review updates, product equivalence, sponsor roles and harms precision require appraisal.","Pregnancy, breastfeeding, pediatric preparations, immunosuppression and validated processing methods need further expansion.","Qualified review, personal infection/toxicity diagnosis and supplement, home-preparation or antiviral regimens are not supplied."]},{"article_id":"milk-thistle","title":"Milk thistle: silymarin mixtures, liver claims, hepatitis C and NASH trials, product quality, and uncertain benefit","words":831,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary liver-trial reconciliation, full sponsor-role/bias appraisal, preparation equivalence and current batch quality remain outstanding.","Other liver diseases, non-oral medicinal preparations, glucose outcomes, lactation and reproductive contexts need separate expansion.","Qualified review, personal liver diagnosis and supplement or treatment regimens are not supplied."]},{"article_id":"ginseng","title":"Ginseng: Asian versus American species, red versus white preparations, fatigue and sexual-function evidence, traditional use, and safety","words":928,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.37","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full trial-level appraisal, updated fatigue/sexual-function synthesis, sponsor roles and preparation equivalence remain outstanding.","Other plants marketed as ginseng, athletic/cognitive/metabolic claims, reproductive safety and long-term outcomes require separate expansion.","Qualified review, personal fatigue or sexual-function diagnosis and supplement or oncology regimens are not supplied."]},{"article_id":"black-cohosh","title":"Black cohosh: plant identity, menopausal symptom evidence, extract and blend differences, conflicting findings, and liver-safety reports","words":918,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.37","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full preparation-specific reconciliation, contemporary guideline comparison, search-cutoff verification, bias and sponsor roles remain outstanding.","Original liver-case appraisal, current batch verification, hormone-sensitive cancer, reproductive contexts and long-term safety require expansion.","Qualified review, personal menopause or liver diagnosis and supplement or hormone-treatment regimens are not supplied."]},{"article_id":"valerian","title":"Valerian: root preparations, subjective versus measured sleep, conflicting trials, European medicinal categories, sedation, and safety gaps","words":961,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Updated sleep guideline/review reconciliation, full trial-level bias, sponsor roles, preparation equivalence and missing-data analysis remain outstanding.","Long-term use, withdrawal reports, combined herbal preparations, reproductive safety and other indications need separate expansion.","Qualified review, personal sleep diagnosis and supplement, sedative or insomnia treatment regimens are not supplied."]},{"article_id":"berberine","title":"Berberine: what it is, weight-loss uncertainty, newer fat-imaging and blend trials, diabetes-study boundaries, drug interactions, and regulatory review","words":887,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.37","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary synthesis of ordinary-berberine diabetes/weight trials, bias, sponsorship, event outcomes and longer-term safety remains outstanding.","EFSA final-opinion/legal-status reconciliation, complete toxicology, current product quality, other botanicals and reproductive contexts require expansion.","Dihydroberberine, other absorption-modified formulations and other indications require dedicated evidence rather than borrowed trial results.","Qualified review, personal metabolic diagnosis and supplement, diabetes or medication-combination regimens are not supplied."]},{"article_id":"cranberry","title":"Cranberry: fruit versus supplements, proanthocyanidins, UTI prevention versus treatment, population differences, and qualified health claims","words":800,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.38","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary prevention/treatment updates, complete trial-level bias, sponsorship, absolute-risk applicability and product equivalence remain outstanding.","PAC assay comparability, current product labeling, stones, medicine interactions and special populations need further expansion.","Qualified review, personal UTI diagnosis and supplement or antibiotic regimens are not supplied."]},{"article_id":"peppermint-oil","title":"Peppermint oil: essential oil versus tea, capsule release, IBS trial disagreements, medicinal-use categories, reflux, and age-specific safety","words":955,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary guideline/review reconciliation, trial bias, secondary endpoints, sponsor roles and preparation equivalence remain outstanding.","Non-IBS indications, combined oils, procedures, pediatric/reproductive contexts, poisoning and ongoing EMA revision need expansion.","Qualified review, personal abdominal-symptom diagnosis and capsule, essential-oil or IBS treatment regimens are not supplied."]},{"article_id":"ginger","title":"Ginger: rhizome versus extracts, nausea versus vomiting, pregnancy evidence, chemotherapy trial disagreements, and two-species osteoarthritis research","words":954,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary reviews, pregnancy safety precision, chemotherapy regimen/outcome differences and complete trial-level bias or sponsor appraisal need reconciliation.","Product chemistry, menstrual-pain, motion-sickness, postoperative and pediatric evidence require further expansion.","Qualified review, personal nausea diagnosis, pregnancy supplementation and oncology or joint-pain regimens are not supplied."]},{"article_id":"garlic","title":"Garlic: food versus extracts, conflicting cholesterol findings, blood-pressure endpoints, gastric-cancer incidence versus mortality, and bleeding or skin risks","words":1045,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary disease-specific reviews, trial inclusion/bias, sponsor roles, responder definitions and preparation equivalence remain incompletely appraised.","Cancer endpoint/factorial interpretation, medication interactions, surgical contexts and reproductive or pediatric evidence need further expansion.","Qualified review, personal lipid/pressure treatment, cancer-prevention supplementation and topical or oral garlic regimens are not supplied."]},{"article_id":"green-tea","title":"Green tea: tea versus concentrated extracts, catechins and EGCG, weight and cancer claims, liver-injury evidence, and a nadolol interaction","words":910,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.38","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary reviews and regulations, complete trial-level bias/sponsorship, genotype analyses and preparation equivalence remain to be reconciled.","Tea types, matcha, decaffeination, pregnancy, pediatric exposures, more medicine interactions and topical prescription labeling need expansion.","Qualified review, personal EGCG safety thresholds, weight-loss supplementation and medication-spacing or liver-treatment regimens are not supplied."]},{"article_id":"saw-palmetto","title":"Saw palmetto: berry extracts, placebo-controlled urinary results, escalating exposure, European medicinal categories, PSA, and safety limits","words":822,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.38","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary reviews and European assessment/labeling, exact preparation comparisons, active-comparator equivalence and later corrections require ongoing reconciliation.","Full trial-level bias, sponsorship, rare safety effects, hair outcomes and special populations require expansion.","Qualified review, personal urinary diagnosis, PSA interpretation and saw-palmetto, hormone or BPH treatment regimens are not supplied."]},{"article_id":"kava","title":"Kava: traditional drinks versus extracts, conflicting generalized-anxiety trials, rare liver injury, case-report limits, and sedative interactions","words":1015,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete contemporary systematic synthesis, trial bias/sponsorship, case-level causality scoring, current LiverTox update and beverage risk-assessment text remain outstanding.","Cultivar/plant-part chemistry, rare-harm frequency, dependence, cognitive effects, regulatory differences and reproductive contexts need further expansion.","Qualified review, personal anxiety or liver diagnosis and kava, sedative or monitoring regimens are not supplied."]},{"article_id":"licorice-root","title":"Licorice root: glycyrrhizin versus DGL, blood-pressure and potassium risks, a small dyspepsia trial, and a newly revised European assessment","words":973,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current EMA monograph, precise crossover duration/results, systematic trial bias/sponsorship and later product-specific efficacy/safety need reconciliation.","Mechanistic clinical appraisal, electrolyte case evidence, topical and respiratory purposes, pregnancy and medicine interactions require further expansion.","Qualified review, personal safe intake thresholds, blood-pressure or potassium treatment and licorice/DGL regimens are not supplied."]},{"article_id":"aloe-vera","title":"Aloe vera: inner gel versus latex and whole leaf, topical versus oral evidence, burn and acne comparisons, animal findings, and laxative regulation","words":862,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.38","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete current burn/skin guidance, trial quality/sponsorship, full IARC monograph, human exposure and commercial preparation equivalence remain incompletely appraised.","Other wound types, oral metabolic/intestinal claims, decolorization chemistry, current regulations and special populations need expansion.","Qualified review, personal burn/wound or cancer-risk assessment and topical, laxative or diabetes aloe regimens are not supplied."]},{"article_id":"passionflower","title":"Passionflower: medicinal plant parts, tea versus extracts, subjective versus measured sleep, a small anxiety comparison, traditional use, and sedation risks","words":970,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary synthesis, full trial-level bias/sponsor roles, endpoint multiplicity, clinical significance and the EMA periodic-review outcome remain outstanding.","Product chemistry, procedural contexts, dependence, combination products, other indications and special populations need expansion.","Qualified review, personal insomnia/anxiety diagnosis and passionflower, sedative or procedural regimens are not supplied."]},{"article_id":"coenzyme-q10","title":"Coenzyme Q10: mitochondrial function, ubiquinone, heart-failure signals, conflicting statin-pain reviews, Parkinson’s trials, and interactions","words":961,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary heart-failure synthesis, full comparison of statin reviews, clinical significance, sponsor roles and trial-level bias remain outstanding.","Ubiquinol versus ubiquinone products, absorption, deficiency disorders, migraine, fertility, cancer contexts and special populations need expansion.","Qualified review, personal symptoms and supplement or medicine regimens are not supplied."]},{"article_id":"alpha-lipoic-acid","title":"Alpha-lipoic acid: thioctic acid, diabetic neuropathy, short versus long trials, primary endpoints, weight claims, and autoimmune hypoglycemia","words":934,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full reconciliation of contemporary neuropathy reviews, their searches, routes, durations, bias and clinical importance remains outstanding.","Product chemistry, other indications, special populations, medicine interactions and current regulatory follow-up need expansion.","Qualified review, personal neuropathy or hypoglycemia diagnosis and supplement or diabetes regimens are not supplied."]},{"article_id":"n-acetylcysteine","title":"N-acetylcysteine: NAC, glutathione, antidote use, COPD findings, conflicting OCD trials, GlyNAC, and supplement policy","words":776,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Contemporary respiratory and psychiatric synthesis, the BRONCUS correction, full PANTHEON primary/subgroup appraisal and complete later marketing-policy history remain outstanding.","Full trial bias, sponsor roles, individual ingredients, long-term harms, other indications, medicines and special populations need expansion.","Qualified review, personal poisoning or psychiatric diagnosis and NAC or treatment regimens are not supplied."]},{"article_id":"taurine","title":"Taurine: biological function, animal longevity findings, disputed aging biomarkers, selected blood-pressure trials, and energy-drink boundaries","words":868,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary human longevity and safety synthesis, complete reconciliation of aging cohorts and newer experimental reports remain outstanding.","Trial missing-data handling, sponsor roles, product exposures, interactions, exercise, other indications and special populations need expansion.","Qualified review, personal biological-age interpretation and taurine or blood-pressure regimens are not supplied."]},{"article_id":"glycine","title":"Glycine: amino-acid function, small sleep studies, daytime tests, the 2026 collagen review, GlyNAC attribution, and longevity uncertainty","words":887,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary trial-level bias, sponsorship, mediation, clinically meaningful sleep effects and long-term safety remain outstanding.","Dietary contributions, other indications, disease-specific studies, medicine compatibility and special populations need expansion.","Qualified review, personal sleep diagnosis and glycine or GlyNAC regimens are not supplied."]},{"article_id":"l-theanine","title":"L-theanine: tea versus isolated supplements, preliminary sleep findings, stress and attention studies, anxiety trials, and claim boundaries","words":817,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete contemporary sleep synthesis, review overlap, caffeine combinations, trial prespecification, clinical importance, full sponsorship and long-term safety appraisal remain outstanding.","Children, pregnancy, medicine interactions and condition-specific indications need expansion.","Qualified review, personal insomnia or anxiety diagnosis and theanine regimens are not supplied."]},{"article_id":"beta-alanine","title":"Beta-alanine: carnosine and buffering, exercise capacity versus performance, male and female evidence, tingling, and safety limits","words":844,"questions":9,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary safety synthesis, underlying-study overlap, sponsor roles, prespecified subgroups and clinical or competitive importance remain outstanding.","Older adults, clinical indications, pregnancy, children, long endurance events, resistance training and medicine or ingredient interactions need expansion.","Qualified review, individualized sport selection and beta-alanine or pre-workout regimens are not supplied."]},{"article_id":"glucosamine","title":"Glucosamine: sulfate versus hydrochloride, conflicting osteoarthritis trials and guidelines, joint-space measures, prevention, longevity associations, and safety","words":798,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary synthesis, guideline updates, product equivalence, trial bias, sponsorship, clinically important effects and reconciliation of conflicting structure findings remain outstanding.","Other joints, cardiovascular and liver associations, allergies, diabetes management, special populations and long-term harms need expansion.","Qualified review, a personal osteoarthritis diagnosis and glucosamine or joint-care regimens are not supplied."]},{"article_id":"chondroitin","title":"Chondroitin: cartilage function, formulation differences, mixed knee evidence, hand osteoarthritis, joint-space outcomes, and conflicting recommendations","words":787,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary synthesis, guideline updates, preparation-specific ESCEO detail, independent trial bias/sponsor appraisal, participant overlap and clinical importance remain outstanding.","Full structural-trial reconciliation, other joints, interactions, allergies, product quality, special populations and long-term safety need expansion.","Qualified review, personal joint diagnosis and chondroitin or arthritis-treatment regimens are not supplied."]},{"article_id":"red-yeast-rice","title":"Red yeast rice: monacolin K and lovastatin, variable products, cholesterol and coronary-event evidence, citrinin, newer safety assessment, and changing claims","words":903,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.39","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary efficacy and safety synthesis, trial-level bias/sponsor roles, modern background care, product equivalence and complete subsequent legal-history review remain outstanding.","Batch-specific composition, citrinin assays, adulteration, individual statin intolerance, interactions and special populations need expansion.","Qualified review, personal cholesterol diagnosis, product clearance and red-yeast-rice or medicine regimens are not supplied."]},{"article_id":"boswellia","title":"Boswellia: gum resin versus frankincense preparations, disputed knee-arthritis reviews, newer trials, combination products, and safety limits","words":735,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary review reconciliation, study overlap, clinically important between-group effects, prespecification, bias and sponsor roles remain outstanding.","Product equivalence, long-term safety, interactions, digestive/respiratory uses, cancer-related contexts and special populations need expansion.","Qualified review, personal disease diagnosis and Boswellia or frankincense regimens are not supplied."]},{"article_id":"msm","title":"MSM: methylsulfonylmethane, small knee-pain studies, mixed arthritis endpoints, a negative prevention trial, combination products, and food-safety boundaries","words":826,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary synthesis, prespecified effects, statistical-report reconciliation, independent clinical importance, trial bias and sponsor roles remain outstanding.","Complete food-notice correspondence, manufacturing specifications, interactions, long-term safety, non-joint purposes and special populations need expansion.","Qualified review, personal pain diagnosis and MSM or food-concentration dosing regimens are not supplied."]},{"article_id":"saffron","title":"Saffron: culinary stigmas versus extracts, low mood and clinical depression, conflicting outcome scales, newer trials, and safety limits","words":768,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary trial-level synthesis, scale-specific certainty, review overlap, attrition, prespecification and sponsor/patent appraisal remain outstanding.","Comparisons with medicines, relapse prevention, other uses, adulteration, interactions, pregnancy, childhood and long-term safety need expansion.","Qualified review, personal psychiatric assessment and saffron or antidepressant-treatment regimens are not supplied."]},{"article_id":"inositol","title":"Inositol: myo and D-chiro forms, PCOS review disagreement, fertility outcomes, pregnancy prevention trials, mood claims, and uncertainty","words":692,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full updated synthesis, overlapping trials, corrections/retractions, guideline currency, pregnancy-trial adherence, study bias and clinical importance remain outstanding.","Formulation ratios, other metabolic and psychiatric uses, diagnosed gestational-diabetes treatment, interactions, long-term safety and special populations need expansion.","Qualified review, individual fertility/pregnancy assessment and inositol or medicine regimens are not supplied."]},{"article_id":"carnitine","title":"Carnitine: endogenous production and forms, prescription deficiency treatment, modest weight findings, exercise intensity, cardiovascular evidence, and TMAO","words":985,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full updated synthesis, modern clinical-outcome trials, underlying trial overlap, form equivalence, study bias and sponsor roles remain outstanding.","Other deficiency settings, acetyl-form neurological/psychiatric uses, fertility, renal disease, interactions and special populations need expansion.","Qualified review, personal deficiency assessment and carnitine, weight-loss or medicine regimens are not supplied."]},{"article_id":"5-htp","title":"5-HTP: serotonin precursor versus tryptophan, weak depression evidence, a small sleep trial, interaction warnings, and disputed historical contamination findings","words":796,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full updated efficacy synthesis, trial overlap, control-adjusted effects, linked sleep comment, statistical reporting and sponsor roles remain outstanding.","Original interaction cases, historical analytical disagreement, current batch quality, other purposes, pregnancy, childhood and long-term safety need expansion.","Qualified review, individual psychiatric/sleep assessment and 5-HTP or medicine-combination regimens are not supplied."]},{"article_id":"dhea","title":"DHEA: a hormone precursor, oral versus vaginal prasterone, aging claims, different guideline contexts, fertility evidence, and safety","words":753,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary synthesis, complete aging-trial endpoint extraction, guideline updates, route-specific efficacy, independent bias and sponsor appraisal remain outstanding.","Long-term endocrine/cancer safety, systemic exposure, interactions, sport eligibility, other purposes and special populations need expansion.","Qualified review, individual hormone/adrenal assessment and oral or vaginal DHEA regimens are not supplied."]},{"article_id":"beta-glucans","title":"Beta-glucans: cereal versus yeast forms, lipid reviews, food matrices, a newer negative bread trial, respiratory claims, and scoped health labels","words":797,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full updated trial-level synthesis, overlapping studies, barley erratum content, matrix/composition effects, clinical importance and sponsor appraisal remain outstanding.","Other glycemic, gastrointestinal and immune purposes, cancer claims, current formulations, interactions, special populations and long-term outcomes need expansion.","Qualified review, individual lipid/diabetes assessment, product compliance and beta-glucan dosing regimens are not supplied."]},{"article_id":"plant-sterols","title":"Plant sterols and stanols: cholesterol absorption, foods versus capsules, lipid evidence versus clinical events, genetic findings, sitosterolemia, and health-claim scope","words":814,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current clinical-event and benefit–risk synthesis, guideline/policy updates, genetic-inference assumptions, overlapping trials and sponsor appraisal remain outstanding.","Free/ester unit conversions, formulation quality, interactions, vitamin-related effects, individual genetic disorders and special populations need expansion.","Qualified review, personal lipid/genetic assessment, product compliance and plant-sterol regimens are not supplied."]},{"article_id":"psyllium","title":"Psyllium: husk and gel-forming fiber, constipation and IBS evidence, lipid and glucose findings, adequate fluid, swallowing warnings, and medicine timing","words":790,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.40","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full current outcome synthesis, trial overlap, comparative fiber forms, sponsor appraisal, clinical importance and event outcomes remain outstanding.","Food/product differences, medicine-specific timing, swallowing disorders, allergies, special populations, long-term use and alternative symptoms need expansion.","Qualified review, individual bowel/glucose assessment and psyllium or medicine regimens are not supplied."]},{"article_id":"fermented-foods","title":"Fermented foods: what they are, live cultures, pickles, yogurt, gut-health evidence, and safety","words":876,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary food-specific synthesis, diet-trial extraction, bias, sponsor roles, overlap and regulatory updates remain outstanding.","Specific products, composition, viable cultures, diagnosed gastrointestinal conditions and long-term clinical outcomes need further appraisal.","Qualified review, individual assessment and home preservation or fermentation protocols are not supplied."]},{"article_id":"raw-milk","title":"Raw milk: what it means, infection risks, nutrition, lactose claims, farm-allergy findings, and testing limits","words":884,"questions":8,"references":6,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary benefit–risk synthesis, outbreak surveillance, vitamin contributions, farm confounding, trial quality and sponsor appraisal remain outstanding.","Current local law, individual dairy products, special populations and complete H5N1 evidence need separate appraisal.","Qualified review, individual allergy assessment and home processing or exposure regimens are not supplied."]},{"article_id":"pasteurization","title":"Pasteurization: why foods are heated, milk labels, homogenization, UHT, refrigeration, nutrients, and virus evidence","words":1548,"questions":11,"references":12,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary thermal/viability synthesis, laboratory versus commercial comparability, detection limits and nutritional contributions remain outstanding.","Post-process contamination, packaging validation, donor human milk, other foods and international requirements need further appraisal.","Qualified review, individual product compliance and home-processing protocols are not supplied."]},{"article_id":"coffee","title":"Coffee: what is in the cup, caffeine amounts, filtering, sleep, and the health evidence","words":1144,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or clinical review has been completed.","Long-term disease prevention is not established by the selected observational evidence.","Commercial caffeine amounts vary; this page has not tested current brands or menus.","Pregnancy, children, interacting medicines, and individual symptom management require separate source-specific coverage."]},{"article_id":"decaf-coffee","title":"Decaf coffee: remaining caffeine, how it is made, solvents, and health evidence","words":954,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or clinical review has been completed.","Head-to-head clinical comparisons of decaffeination methods were not established by the selected sources.","No current commercial product was tested for caffeine or solvent residues.","The male bladder-cancer finding needs further study and full appraisal; the selected abstract does not identify the extraction method or residue exposure."]},{"article_id":"energy-drinks","title":"Energy drinks: caffeine, sugar, extra ingredients, heart studies, and everyday questions","words":951,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or clinical review has been completed.","The selected high-volume trials do not establish absolute serious-event risks for ordinary servings or chronic use.","These references overlap in background evidence and trial authorship; reference count is not a count of independent replications.","Current commercial formulations, label compliance, and individual medication interactions have not been comprehensively assessed."]},{"article_id":"organic-food","title":"Organic food: what the label means, pesticides, nutrition, and health evidence","words":1354,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete appraisal of the 2026 cohort outcome estimates and subgroup analyses remains pending.","No independent exhaustive synthesis of long-term clinical outcomes, farming impacts, or individual product-residue data is provided."]},{"article_id":"sugar-alcohols","title":"Sugar alcohols: erythritol, xylitol, calories, gut effects, and heart-risk uncertainty","words":967,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No comprehensive update of dental evidence after the Cochrane 2014 search cutoff is provided.","Long-term randomized cardiovascular-outcome evidence and individual safe-use thresholds were not established by the selected studies."]},{"article_id":"monosodium-glutamate","title":"MSG: umami flavor, naturally occurring glutamate, sodium, and sensitivity evidence","words":938,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A complete synthesis of newer challenge studies, long-term outcomes, and current EU use-level legislation remains pending.","Individual headache causes or reproducible sensitivity cannot be determined from this overview."]},{"article_id":"food-emulsifiers","title":"Food emulsifiers: what they do, common ingredients, and gut-health uncertainty","words":1649,"questions":10,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.41","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A complete appraisal of the mouse-paper correction, cohort supplements, and newer intervention studies remains pending.","This is not an exhaustive ingredient-by-ingredient inventory or a current compliance guide for every jurisdiction, infant food, or medical formula."]},{"article_id":"frozen-and-canned-foods","title":"Frozen and canned foods: preservation, nutrients, ingredients, freezer burn, refrigeration, and everyday comparisons","words":831,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete contemporary composition synthesis, crop-specific vitamin extraction, study sponsorship and links to actual dietary outcomes remain unfinished.","Container contaminants, cold-chain failures, individual recalls and complete home-canning procedures need separate appraisal; no brand ranking or personal diet is supplied."]},{"article_id":"microwave-cooking","title":"Microwave cooking: how heating works, radiation myths, nutrients, uneven heating, containers, and plastic-particle research","words":881,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary composition comparisons, clinically relevant particle-exposure studies and complete modeling appraisal remain unfinished.","The identified 2024 correspondence and any response to the 2023 plastic study need appraisal; actual products and appliance-specific instructions cannot be certified from these studies."]},{"article_id":"air-fryers","title":"Air fryers: hot-air cooking, oil uptake, acrylamide disagreement, a published critique, and food-safety checks","words":1199,"questions":12,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Full contemporary analytical synthesis, disputed measurement reconciliation and any author response remain unfinished.","Food-specific long-term clinical outcomes, coating/material issues and brand-specific product or appliance validation need separate work; no personal risk calculation is supplied."]},{"article_id":"sparkling-water","title":"Sparkling water: bubbles, minerals, flavored drinks, hydration, teeth, and bloating","words":838,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or qualified clinical review has been completed.","Laboratory erosion is not a measurement of long-term tooth damage in an individual.","Current brands have not been tested or ranked; formulation and mineral composition vary.","The hydration trial did not study illness treatment, strenuous exercise, or every population."]},{"article_id":"bottled-water","title":"Bottled water: sources, treatment, labels, tap-water comparisons, and microplastics","words":1063,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or qualified clinical review has been completed.","The selected particle measurements do not estimate disease risk from a particular bottle.","No brand ranking, batch verification, or individualized tap-water testing has been performed.","The 2019 WHO overview and dated surveillance do not settle all later evidence or current contaminant-specific legal standards."]},{"article_id":"sports-drinks","title":"Sports drinks: fluid, carbohydrate, electrolytes, everyday use, and medical rehydration","words":947,"questions":10,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or qualified clinical review has been completed.","These sources do not compare every modern product, activity, or personal sweat profile.","Several guidance sources share background evidence; reference count is not independent replication.","Older statements retain their dates, and full subsequent policy history has not been comprehensively reviewed."]},{"article_id":"olive-oil","title":"Olive oil: extra virgin, refined, cooking, and what the health evidence means","words":1148,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent synthesis isolates extra virgin oil from the complete dietary pattern across long-term clinical trials.","Cooking and storage experiments do not provide a universal clinical ranking of brands, phenol levels, or cooking methods."]},{"article_id":"protein-powders","title":"Protein powders: whey, casein, plant proteins, and what a scoop can offer","words":1457,"questions":10,"references":13,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent comparison establishes the best current brand, flavor, or ingredient blend for every consumer.","Disease-specific protein needs, individual dosing, and every possible powder ingredient are outside this product explainer."]},{"article_id":"plant-based-milks","title":"Plant-based milks: soy, oat, almond, coconut, and how nutrition differs","words":1231,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The older product samples are not current inventories of every country’s market; individual labels still require checking.","Long-term clinical outcomes and direct dairy comparisons for each plant-drink family have not been independently synthesized here."]},{"article_id":"nutrition-labels","title":"Nutrition labels: servings, sugars, Daily Values, ingredients, and package claims","words":1656,"questions":11,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.42","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["This is a consumer explanation, not an exhaustive legal manual for every exemption, rounding rule, age-specific label, or jurisdiction.","Front-of-pack schemes and every regulated nutrition or health claim require separate jurisdiction-specific explanations."]},{"article_id":"butter-and-margarine","title":"Butter and margarine","words":1278,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Private-label and newer formulations may differ from the 2020 marketplace study.","The cited evidence does not rank current brands or establish randomized long-term disease effects for every spread."]},{"article_id":"coconut-oil","title":"Coconut oil","words":1299,"questions":10,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Selected evidence does not establish long-term randomized cardiovascular outcomes for coconut oil.","The cited reviews overlap studies and use different comparator and eligibility rules; they are not independent replications.","Product-specific storage and cooking instructions still govern use; this article does not assign a universal shelf life or smoke-point temperature."]},{"article_id":"non-stick-cookware","title":"Non-stick cookware","words":1098,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected studies do not establish long-term disease risk from each household’s use or wear pattern.","No complete brand ranking, global legal inventory or independent laboratory product testing has been performed."]},{"article_id":"plastic-food-containers","title":"Plastic food containers","words":1433,"questions":11,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected particle experiment does not establish long-term disease risk or rank all current products.","The agency disagreement has been explained from the agencies’ own materials; no independent full reappraisal of the underlying BPA evidence is claimed.","A product’s manufacturer instructions and applicable local rules still need checking; this is not a complete global legal or product-certification inventory."]},{"article_id":"toothpaste","title":"Toothpaste: fluoride, whitening, sensitivity, charcoal, and fluoride-free alternatives","words":1019,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or qualified dental review has been completed.","Products, outcomes, funding, and eligibility differ; reference count does not establish independent replication.","The dated charcoal review does not comprehensively assess all later formulations.","Hydroxyapatite conclusions remain formulation-specific; full comparative evidence and independent replication require further appraisal."]},{"article_id":"soap-and-hand-sanitizer","title":"Soap and hand sanitizer: detergents, antibacterial claims, alcohol, skin comfort, and real-world evidence","words":1023,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or qualified clinical review has been completed.","The selected trials compare combined programs in particular settings, not isolated ingredients or every consumer product.","No batch-specific product verification or complete current regulatory-order review has been performed.","Formulation-specific effectiveness, individual tolerability, and all later comparative infection trials require further appraisal."]},{"article_id":"deodorants-and-antiperspirants","title":"Deodorants and antiperspirants: odor, sweat, aluminum, cancer evidence, and skin reactions","words":1061,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No independent systematic synthesis or qualified clinical review has been completed.","Cancer sources share some underlying studies; mixed observational evidence and mechanistic hypotheses are not independent causal proof.","The small exposure study and conditional regulatory assessment do not establish lifetime clinical outcomes for every formulation.","Full subsequent monograph/opinion history, contemporary ingredient-allergy prevalence and individual product compliance remain outside this selected-source review."]},{"article_id":"household-cleaners","title":"Household cleaners: detergents, disinfectants, bleach, green claims, and asthma evidence","words":1337,"questions":11,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full systematic review of exposure patterns and respiratory outcomes remains needed.","Individual formulations, occupational exposures, and local product rules are not comprehensively reviewed."]},{"article_id":"laundry-detergents","title":"Laundry detergents: ingredients, fragrance, enzymes, skin reactions, and concentrated packets","words":1195,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current population-level skin reaction rates and comparative formulation studies need broader review.","Occupational enzyme exposure and current brand/batch or package compliance have not been comprehensively appraised."]},{"article_id":"food-irradiation","title":"Food irradiation: what it is, radiation myths, nutrients, chemical changes, and labels","words":986,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.43","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual treatment conditions, complete modern toxicology and nutrition syntheses, and national food authorizations require more detailed review.","The references include overlapping agency background; they are not seven independent human clinical experiments."]},{"article_id":"eggs","title":"Eggs: whites and yolks, labels, cholesterol, heart evidence, and food safety","words":1173,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected sources are not an exhaustive current systematic review or qualified clinical assessment.","Long-term randomized cardiovascular-event comparisons of ordinary egg-containing diets remain outside this source set.","Selected original abstract and design details plus the 2025 corrigendum have been incorporated; full Methods and independent risk-of-bias appraisal remain incomplete.","Several original sources were accessible only through selected indexed passages; complete funding and bias appraisal remains incomplete."]},{"article_id":"yogurt","title":"Yogurt: Greek, plant-based, live cultures, sugar, lactose, and health claims","words":911,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No exhaustive current yogurt trial review or qualified clinical assessment has been completed.","The product-composition study does not cover all current formulations or establish clinical equivalence between plant and dairy products.","Strain-specific probiotic treatment effects are outside this product explainer and require separate condition-specific appraisal.","Some extension and agency material was accessible only in original indexed passages; the high-protein notice is dated, rather than a complete regulatory update history."]},{"article_id":"cheese","title":"Cheese: natural and processed types, nutrients, lactose, heart studies, and storage","words":1174,"questions":10,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No exhaustive current cheese review or qualified clinical assessment has been completed.","Long-term randomized clinical-event evidence, every cheese subtype and every nondairy replacement are outside this selected source set.","Some original studies and agency passages were available only as indexed extracts; full funding and bias appraisal remains incomplete.","Nutrient composition and food safety vary by actual formulation, manufacturing and handling, which were not tested product by product."]},{"article_id":"chocolate","title":"Chocolate and cocoa: types, processing, health studies, metals, and milk allergy","words":1415,"questions":10,"references":15,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No exhaustive current cocoa/chocolate trial review or qualified clinical assessment has been completed.","Ordinary bars, analytical flavanol measures and standardized extracts are not interchangeable exposure evidence.","The selected metal survey is not a representative current brand ranking and did not measure clinical injury in consumers.","Some original studies were accessible only through indexed passages; full funding, multiplicity and causal appraisal remains incomplete."]},{"article_id":"wholegrain-bread","title":"Wholegrain bread","words":968,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected acute and one-week experiments do not establish long-term effects for every loaf or isolate every aspect of processing.","Current brand rankings and a complete international survey of bread-name requirements have not been performed."]},{"article_id":"breakfast-cereals","title":"Breakfast cereals","words":1150,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No complete search through October 2026, current brand ranking or independent verification of product labels has been completed.","Acute meal findings and observational dietary associations do not establish disease-prevention or weight-loss effects for every cereal."]},{"article_id":"nuts-and-seeds","title":"Nuts and seeds","words":1111,"questions":9,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Tree-nut studies do not establish matching effects for every seed or prepared product; no independent comparative ranking of all nuts and seeds has been performed.","Concentrated supplements, infant feeding and individualized allergy management are outside this food-shopping overview."]},{"article_id":"juice-and-smoothies","title":"Juice and smoothies","words":1103,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected acute experiments do not establish effects for every commercial smoothie recipe or longer-term glucose outcomes.","No complete search through October 2026, brand comparison or independent full-text appraisal has been completed; the Codex full standard could not be retrieved directly."]},{"article_id":"red-meat","title":"Red meat","words":1017,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The overview is not a complete appraisal of all meat subtypes, farming systems, preparation practices or global dietary guidelines.","Independent full-text appraisal and reconciliation of all review-level risk-of-bias and funding details remain pending.","Short risk-factor trials and long-term observational outcomes do not provide one definitive personal-risk estimate."]},{"article_id":"fish-and-seafood","title":"Fish and seafood","words":1095,"questions":9,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.44","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["This is not a complete species/contaminant database or a current advisory for every fishing location.","Independent full-text appraisal and reconciliation of every seafood review, funding disclosure and later guideline change remain pending.","Existing observational findings do not establish an identical benefit from all species, preparations or populations."]},{"article_id":"fruit","title":"Fruit","words":957,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected older review and cohort reports are not a complete synthesis through October2026.","Several papers were available only as original indexed passages; funding, methods and bias appraisal are incomplete where stated.","No universal fruit ranking, individual disease diet or expert-reviewed personal portion recommendation is established here."]},{"article_id":"vegetables","title":"Vegetables","words":833,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Selected studies do not constitute a complete synthesis of every vegetable, cooking method or health outcome.","The indexed MyPlate explanation provides food-group terminology; current direct retrieval and comprehensive US dietary-policy review were unavailable.","Short-term blood pressure, laboratory compound retention and observational mortality are distinct outcomes; no individual treatment prescription is established."]},{"article_id":"legumes-and-beans","title":"Legumes and beans","words":1188,"questions":9,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No exhaustive contemporary legume-outcome synthesis or qualified review completed.","The canned-bean paper numerical results were not retrieved; no fixed sodium-reduction percentage is asserted.","Food allergy management and gastrointestinal treatment require separate individual assessment."]},{"article_id":"potatoes","title":"Potatoes","words":969,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Agency raw-potato refrigerator advice differs as of the check date; later harmonization would trigger an update.","Selected laboratory and small feeding studies do not settle long-term disease outcomes.","No independent systematic review, funding appraisal or qualified clinical review completed."]},{"article_id":"rice","title":"Rice","words":1055,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Selected older glucose reviews are not a current comprehensive synthesis; product-specific effects remain variable.","The2021 review was accessed through original indexed abstract passages, not full-text appraisal.","Home rice handling times here are specifically UK FSA guidance, not a harmonized international legal standard."]},{"article_id":"pasta","title":"Pasta","words":978,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Selected meal experiments and older reviews do not establish universal GI values or long-term disease protection.","The weight review studied dietary patterns containing pasta, not isolated pasta effects.","Several sources were available only through original indexed abstracts/results; no independent full-text or qualified clinical review completed."]},{"article_id":"dried-fruit","title":"Dried fruit","words":1035,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term disease outcomes and smaller usual-serving comparisons remain outside these short trials.","Prune full-text methods and funding were not accessible through the two bounded retrieval routes.","The NHS page displays a 2022 review and a 2025 next-review date; no completed later review was verified."]},{"article_id":"soya-foods","title":"Soya foods","words":1229,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term product-specific clinical outcomes are not established by these short protein and hormone studies.","The selected hormone review has a small evidence base for several outcomes; it cannot answer all fertility or life-stage questions.","Complete study-level funding and independent risk-of-bias appraisal of the LDL review remain incomplete; the UCSF composition table has no verified recent review date."]},{"article_id":"plant-based-meat-alternatives","title":"Plant-based meat alternatives","words":938,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term product-specific clinical outcomes remain untested by these short trials.","The 2021 survey and 2022 ingredient examples do not describe every current formulation.","Full funding/conflict and sampling detail of the UK survey were unavailable through the bounded primary retrieval routes."]},{"article_id":"ready-meals-and-takeaways","title":"Ready meals and takeaways","words":1088,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.45","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These dated composition studies do not describe every current meal or typical home-cooked alternative.","Product-specific long-term causal health effects are not established by the selected observational cohort.","Full methods, funding/conflict inspection and independent bias appraisal remain incomplete for several studies; no global comparison of delivery regulation or product labelling was completed."]},{"article_id":"black-tea","title":"Black tea","words":1123,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific long-term causal prevention claim follows from these trials and cohort.","The full text of the indexed cohort correction and several complete funding/conflict records remained unavailable or uninspected.","The selected product analysis is dated and does not establish caffeine totals for every current product or brewing method."]},{"article_id":"herbal-teas","title":"Herbal teas","words":1207,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected short, preparation-specific studies do not establish effects for all herbal blends or long-term disease outcomes.","Full study methods, funding/conflicts and independent bias appraisal remain incomplete for several research references.","Pregnancy, breastfeeding and medicine questions depend on the particular plant and preparation; the EMA periodic review has not been treated as a new final guidance conclusion."]},{"article_id":"soft-drinks","title":"Soft drinks","words":969,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The dated diabetes synthesis is not an exhaustive assessment through 2026, and beverage cohorts cannot resolve every causal claim.","Complete trial disclosures and several full-text methods/appraisal passages were not available or inspected.","Product formulations and portions vary; none of the cited research establishes a health ranking for every current brand."]},{"article_id":"peanut-butter-and-nut-spreads","title":"Peanut butter and nut spreads","words":1211,"questions":9,"references":10,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No contemporary comprehensive nut-spread outcome synthesis or independent qualified review completed.","Small food-form and meal experiments do not establish long-term diabetes or weight outcomes.","Several original studies and one guidance page were inspected through indexed passages rather than full-text retrieval."]},{"article_id":"ice-cream-and-frozen-desserts","title":"Ice cream and frozen desserts","words":1028,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No comprehensive current frozen-dessert outcome synthesis or qualified independent review completed.","A product-label survey describes its sampled market rather than every current formulation.","Some original explanatory passages and survey results were retrieved through indexing or an author-identical university reprint."]},{"article_id":"snack-bars","title":"Snack bars","words":1052,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No comprehensive current market survey or bar-specific long-term disease synthesis completed.","Short-term calorie compensation in young adults does not settle sustained weight effects in other populations.","Exact contemporary products and individual allergy or digestive tolerance require product-specific checks."]},{"article_id":"chicken-and-poultry","title":"Chicken and poultry","words":1307,"questions":11,"references":11,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected trial assesses short-term blood outcomes rather than clinical cardiovascular events.","The dated scoping review maps research without synthesizing outcomes or grading certainty; it is not a complete current disease-risk review.","Some sources were available only as original indexed passages. No universal healthiest cut, individual disease diet or independent expert review is established."]},{"article_id":"water-filters","title":"Water filters","words":1584,"questions":12,"references":14,"depth_status":{"status":"expanded_explainer","edition":"3.46","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The selected field study does not test every current product or measure illness outcomes.","Whole-paper device appraisal and an independent current certification-directory audit have not been completed.","Local test results and applicable emergency instructions cannot be inferred from taste or a general product name."]},{"article_id":"honey","title":"Honey: sugars, varieties, cough evidence, authenticity and infant safety","words":921,"questions":10,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term clinical outcomes and product-specific effects remain incompletely studied."]},{"article_id":"vinegar","title":"Vinegar: food types, acidity, apple cider claims and evidence quality","words":824,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term clinical outcomes and product-specific effects remain incompletely studied."]},{"article_id":"energy-balance","title":"Energy balance: calories, metabolism, adaptation, and why predictions vary","words":674,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual prediction errors across disease and medication contexts","No independent appraisal of all diet-comparison trials"]},{"article_id":"appetite-and-satiety","title":"Appetite and satiety: hunger, fullness, eating rate, and biological regulation","words":669,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Durability and real-world comparison of appetite-focused interventions","How individual illness, medicines and eating disorders affect interpretation"]},{"article_id":"carbohydrate-types","title":"Carbohydrates: sugars, starches, fiber, food quality, and blood glucose","words":1777,"questions":14,"references":16,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term comparison of glycemic-index strategies and complete eating patterns","Independent appraisal of carbohydrate-specific clinical evidence across diabetes populations"]},{"article_id":"dietary-fat-types","title":"Dietary fats: saturated, unsaturated, trans fats, and the importance of replacement","words":1103,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Food-matrix-specific long-term comparisons beyond broad fatty-acid classes","Independent systematic appraisal of hard clinical outcomes and individual fatty acids"]},{"article_id":"inflammation","title":"Inflammation: useful defense, chronic disease, biomarkers, and treatment limits","words":1202,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent comparative review of dietary-pattern claims and inflammatory outcomes","Translation of resolution biology into condition-specific clinical benefit"]},{"article_id":"homeostasis-allostasis","title":"Homeostasis and allostasis: how the body regulates, adapts, and changes","words":732,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual clinical utility of allostatic-load algorithms","Comparative tests of regulatory frameworks across contexts"]},{"article_id":"acute-kidney-injury","title":"Acute kidney injury: sudden loss of kidney function","words":819,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparison of subtype-specific management and long-term outcomes; selected sources do not constitute a systematic synthesis."]},{"article_id":"acute-bronchitis","title":"Acute bronchitis: a chest cold is not every kind of cough","words":679,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparison of subtype-specific management and long-term outcomes; selected sources do not constitute a systematic synthesis."]},{"article_id":"cirrhosis","title":"Cirrhosis: scarring, disease stage and prevention of complications","words":784,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparison of subtype-specific management and long-term outcomes; selected sources do not constitute a systematic synthesis."]},{"article_id":"interstitial-lung-disease","title":"Interstitial lung disease: one umbrella, several different causes","words":690,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparison of subtype-specific management and long-term outcomes; selected sources do not constitute a systematic synthesis."]},{"article_id":"hepatitis-a","title":"Hepatitis A: spread, recovery and prevention after exposure","words":683,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparison of subtype-specific management and long-term outcomes; selected sources do not constitute a systematic synthesis."]},{"article_id":"urinary-retention","title":"Urinary retention: difficulty emptying the bladder","words":919,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A full comparison of subtype-specific management and long-term outcomes; selected sources do not constitute a systematic synthesis."]},{"article_id":"walking-and-step-counts","title":"Walking and step counts: intensity, realistic goals, health associations, and what trackers miss","words":963,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive systematic search have not been completed.","Long-term outcomes, harms and applicability to unstudied populations remain uncertain."]},{"article_id":"high-intensity-interval-training","title":"HIIT: hard intervals, sprint training, time savings, fitness evidence, and safety","words":848,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive systematic search have not been completed.","Long-term outcomes, harms and applicability to unstudied populations remain uncertain."]},{"article_id":"exercise-snacks","title":"Exercise snacks: short activity bouts, sitting breaks, fitness, and blood-glucose evidence","words":788,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive systematic search have not been completed.","Long-term outcomes, harms and applicability to unstudied populations remain uncertain."]},{"article_id":"recovery-and-overtraining","title":"Recovery and overtraining: normal fatigue, overload, persistent underperformance, and uncertain tests","words":659,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive systematic search have not been completed.","Long-term outcomes, harms and applicability to unstudied populations remain uncertain."]},{"article_id":"relative-energy-deficiency-in-sport","title":"Relative energy deficiency in sport: under-fuelling, REDs, clinical assessment, and competing interpretations","words":677,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive systematic search have not been completed.","Long-term outcomes, harms and applicability to unstudied populations remain uncertain."]},{"article_id":"warm-up-and-cool-down","title":"Warm-up and cool-down: preparation, injury programs, soreness, stretching, and lactate myths","words":1066,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive systematic search have not been completed.","Long-term outcomes, harms and applicability to unstudied populations remain uncertain."]},{"article_id":"grief-and-prolonged-grief","title":"Grief: ordinary bereavement, prolonged grief, cultural context and treatment evidence","words":797,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative durability, access, culturally appropriate support and individual treatment suitability require fuller appraisal.","This page has not undergone qualified independent medical review."]},{"article_id":"postpartum-depression","title":"Postpartum depression: baby blues, perinatal timing, screening, treatment and psychosis","words":855,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative durability, access, culturally appropriate support and individual treatment suitability require fuller appraisal.","This page has not undergone qualified independent medical review."]},{"article_id":"social-media-and-mental-health","title":"Social media use: content, connection, problematic use, mental-health associations and digital breaks","words":802,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Durability,individual differences,work or family context and comparative effectiveness need fuller appraisal.","No qualified independent medical review or individual diagnosis is supplied."]},{"article_id":"shift-work-sleep-disorder","title":"Shift work sleep disorder: body-clock misalignment, sleepiness, assessment, adaptation and treatment limits","words":818,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Durability,individual differences,work or family context and comparative effectiveness need fuller appraisal.","No qualified independent medical review or individual diagnosis is supplied."]},{"article_id":"body-focused-repetitive-behaviors","title":"Body-focused repetitive behaviors: hair pulling, skin picking, habit reversal and conflicting treatment trials","words":1041,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term outcomes,individual differences and comparative interventions need fuller appraisal.","This page has not undergone qualified independent medical review."]},{"article_id":"infant-sleep-safety","title":"Infant sleep safety: SIDS, suffocation, room sharing, bed-sharing evidence and monitor claims","words":939,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"private-completion-2026-10-13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term outcomes,individual differences and comparative interventions need fuller appraisal.","This page has not undergone qualified independent medical review."]},{"article_id":"air-fresheners","title":"Air fresheners: fragrance, diffusers, VOCs, ozone chemistry and what evidence can establish","words":860,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No exhaustive product-by-product emissions ranking or individual risk threshold is supplied.","Long-term causal health evidence, ingredient-specific effects and independent full-text appraisal remain incomplete."]},{"article_id":"candles-and-incense","title":"Candles and incense: combustion, fragrance, soot, disease studies and fire safety","words":735,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["There is no universally safe burn time or complete wax-by-wick exposure ranking in this selected-source overview.","Long-term causal comparisons and complete industry-funding and risk-of-bias appraisal remain incomplete."]},{"article_id":"air-purifiers","title":"Air purifiers: HEPA, gas filters, CADR, ozone, certifications and health-outcome uncertainty","words":1299,"questions":9,"references":12,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No brand ranking, universal room-size prescription or guarantee of disease prevention is provided.","Long-term clinical effects across technologies, pollutant mixtures and populations need further synthesis and qualified review."]},{"article_id":"bpa-free-and-pfas-free-claims","title":"BPA-free and PFAS-free claims: chemical identity, substitutes, testing and the limits of a label","words":662,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The page does not certify products, interpret an individual regulatory case or supply a universal definition of toxin-free.","Comparative substitute hazard, migration under actual use and complete current legal application need case-specific verification."]},{"article_id":"laboratory-detection-limits","title":"Laboratory detection limits: non-detects, quantification, uncertainty and what a product test can tell you","words":741,"questions":7,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["This is laboratory-result literacy, not clinical interpretation or a complete sampling/method-validation protocol.","No individual pass/fail verdict, laboratory endorsement or contaminant health threshold is supplied."]},{"article_id":"glass-and-ceramic-foodware","title":"Glass and ceramic foodware: glazes, decoration, leaching, lead-free claims and heat limits","words":939,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.0","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No current brand ranking, complete all-metals certification or personal blood-lead assessment is supplied.","Product-specific leach methods, wear, full current regulatory tables and contemporary heat-strengthening comparisons require further appraisal."]},{"article_id":"prebiotics","title":"Prebiotics: substrates, fibers, gut microbes and indication-specific benefits","words":721,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which formulations offer sustained symptom benefit rather than only microbiota changes?","How should longer studies assess tolerability and baseline microbiome differences?"]},{"article_id":"histamine-intolerance","title":"Histamine in foods and intolerance claims: mechanisms, tests and competing explanations","words":790,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Can independent blinded trials validate a reproducible subgroup and diagnostic standard?","Which dietary or enzyme interventions outperform appropriate controls?"]},{"article_id":"portion-sizes","title":"Portion sizes: label servings, energy density and what experiments show","words":1038,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How durable are portion interventions outside controlled feeding settings?","How should adequate intake and eating-disorder-sensitive care shape individualized use?"]},{"article_id":"meal-planning","title":"Meal planning: flexible routines, food access and what the evidence can establish","words":804,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which planning interventions improve diet quality independent of other support?","How do cost, food access, fatigue and storage limitations change usefulness?"]},{"article_id":"indoor-mold","title":"Indoor mold: damp buildings, testing, remediation and illness claims","words":1132,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The particular damp-building exposures causing symptoms and a universally applicable quantitative health threshold remain unresolved."]},{"article_id":"humidifiers","title":"Humidifiers: mist types, mineral dust, cleaning and realistic benefits","words":720,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term household benefits and risks by device, maintenance quality and water chemistry are incompletely quantified."]},{"article_id":"dehumidifiers","title":"Dehumidifiers: humidity, capacity, moisture control and limits of health claims","words":787,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Health benefits depend on achieved conditions, housing and susceptibility; current-device clinical effects are not established by the older small studies."]},{"article_id":"perfume-and-fragrance","title":"Perfume and fragrance: ingredients, allergy, respiratory symptoms and labels","words":1294,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Specific fragrance ingredients, dose-response relationships and individual respiratory mechanisms remain variable and incompletely resolved."]},{"article_id":"cosmetics-and-ingredient-safety","title":"Cosmetics and ingredient safety: product categories, exposure, labels and preservation","words":1054,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Product-specific exposure, replacement ingredient tradeoffs and personal allergy cannot be predicted from marketing or an ingredient list alone."]},{"article_id":"nail-products","title":"Nail products: polish, gels, acrylate allergy, salon exposure and UV lamps","words":929,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Absolute cancer risk from ordinary curing-lamp use and the safety of each replacement formulation are not established by the cited cell study or ingredient rules."]},{"article_id":"stainless-steel-cookware","title":"Stainless steel cookware: alloys, metal migration and what risk evidence means","words":712,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current product-specific migration and clinical benefits of changing cookware in sensitized people need further direct study."]},{"article_id":"food-poisoning","title":"Food poisoning: infections, toxins, symptoms, hydration and preventing spread","words":819,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A specific source or pathogen often cannot be established from symptoms alone; test selection depends on the illness and public-health context."]},{"article_id":"boil-water-advisories","title":"Boil-water advisories: notice types, safe uses, filters and returning to normal","words":898,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The incident contaminant, affected area, duration and local lifting/cleanup procedures must come from the current utility or health-authority notice."]},{"article_id":"carbon-monoxide","title":"Carbon monoxide: sources, CO versus CO₂, alarm limits and urgent response","words":1181,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Exposure severity cannot be inferred from a home sensor or isolated blood value; follow emergency responders’ and clinicians’ instructions."]},{"article_id":"hormonal-contraception","title":"Hormonal contraception: combined methods, progestin-only options and choosing safely","words":741,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"emergency-contraception","title":"Emergency contraception: pills, IUDs, timing and what the evidence can establish","words":790,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"fertility-tracking","title":"Fertility tracking: calendars, temperature, mucus, LH tests and contraception boundaries","words":904,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"female-infertility","title":"Female infertility: ovulation, tubes, ovarian reserve and treatment outcomes","words":1084,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"male-infertility","title":"Male infertility: sperm production, obstruction, semen tests and supplement claims","words":935,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"breastfeeding","title":"Breastfeeding: milk production, feeding patterns, benefits and practical support","words":944,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"lactation-problems","title":"Lactation problems: low supply, milk transfer, pain and the mastitis spectrum","words":804,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"falls-prevention","title":"Falls prevention: balance, home hazards, medication review and interpreting trial results","words":925,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"frailty","title":"Frailty: reduced reserve, different measurement models and maintaining function","words":955,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"polypharmacy-and-deprescribing","title":"Polypharmacy and deprescribing: appropriate combinations, medication review and safe change","words":963,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["These selected sources do not resolve every individual treatment choice or subgroup outcome.","Independent medical review and an exhaustive evidence synthesis have not been completed."]},{"article_id":"naps","title":"Naps: planned rest, sleep inertia, alertness and long-term health claims","words":835,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No nap prescription for children, sleep disorders or safety-sensitive occupations is supplied.","Long-term causal effects and optimal individual nap timing remain unresolved."]},{"article_id":"chronotype","title":"Chronotype: morningness, eveningness, measurement and schedule mismatch","words":869,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Clinical diagnosis and individualized light or medication timing are outside this overview.","Long-term superiority of schedule shifting versus accommodation and the distinct contributions of intervention components remain unresolved."]},{"article_id":"circadian-misalignment","title":"Circadian misalignment: body-clock timing, sleep schedules and metabolic evidence","words":1318,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized light, medication or meal-timing protocol is supplied.","Real-world long-term disease prevention and feasibility across occupations remain uncertain."]},{"article_id":"mouth-taping","title":"Mouth taping: oral closure, selected sleep-apnea studies and airway-dependent risks","words":893,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No safe unsupervised taping protocol, product ranking or replacement for clinical apnea assessment is supplied.","Long-term outcomes, adverse-event frequency and selection of potential responders remain insufficiently established."]},{"article_id":"blue-light-glasses","title":"Blue light glasses: eye-strain claims, amber evening lenses and sleep evidence","words":923,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No brand ranking, individual light-timing protocol or pediatric treatment recommendation is supplied.","Long-term clinical outcomes, spectral comparability and harms require further study."]},{"article_id":"burnout","title":"Burnout: workplace stress, exhaustion, measurement and organizational responses","words":1268,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["This page supplies no psychiatric diagnosis, occupational certification or universal recovery timeline.","Comparative long-term effectiveness outside physician settings and the diagnostic boundaries remain debated."]},{"article_id":"caregiver-stress","title":"Caregiver stress: demands, resources, support and conflicting health findings","words":1227,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No caregiver psychiatric diagnosis, service eligibility decision or individual mortality estimate is supplied.","Evidence is concentrated in dementia/cancer settings; practical support access and long-term outcomes differ across roles."]},{"article_id":"procrastination","title":"Procrastination: harmful delay, emotion regulation, bedtime patterns and treatment evidence","words":864,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No psychiatric diagnosis or individualized treatment protocol is supplied.","Long-term clinical benefits, intervention component effects and generalization beyond selected student/volunteer samples remain uncertain."]},{"article_id":"attention-and-distraction","title":"Attention and distraction: alertness, selection, switching and ordinary lapses","words":829,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individual cognitive assessment, ADHD diagnosis or guaranteed focus-training program is supplied.","Effects of specific real-world workplace strategies and permanent cognitive change cannot be inferred from brief laboratory tasks."]},{"article_id":"digital-wellbeing","title":"Digital wellbeing: useful connection, unwanted habits, measurement and digital breaks","words":890,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized screen-time threshold, addiction diagnosis or replacement for mental-health treatment is supplied.","Long-term effects, children, essential-use requirements and selection/adherence limitations need further appraisal."]},{"article_id":"home-blood-pressure","title":"Home blood pressure: cuffs, technique, repeated readings and treatment evidence","words":1031,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"heart-rate-variability","title":"Heart rate variability: beat timing, metrics, wearable validation and stress claims","words":1231,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"continuous-glucose-monitoring","title":"Continuous glucose monitoring: interstitial sensors, diabetes benefits and wellness uncertainty","words":1198,"questions":9,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"blood-glucose-meters","title":"Blood glucose meters: finger-stick measurements, strips, error and diagnostic limits","words":994,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"biological-age-tests","title":"Biological age tests: clock families, risk prediction, repeatability and longevity claims","words":1179,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"cortisol-testing","title":"Cortisol testing: daily rhythms, specimens, dynamic tests and misleading stress claims","words":1228,"questions":10,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"thyroid-testing","title":"Thyroid testing: TSH, free and total hormones, antibodies and misleading results","words":1175,"questions":9,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"testosterone-testing","title":"Testosterone testing: total and free hormone, repeat samples, assay quality and interpretation","words":775,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"body-composition-measurement","title":"Body composition measurement: fat, lean tissue, smart scales, DXA and change detection","words":797,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"pulse-oximetry","title":"Pulse oximetry: saturation estimates, hidden hypoxemia, skin pigmentation and home monitoring","words":789,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","Individual test interpretation, current brand ranking and personalized treatment decisions are outside this explainer."]},{"article_id":"lead","title":"Lead: metal sources, dust and water, blood testing, reference values and prevention","words":858,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personalized treatment or house-specific source investigation is provided.","Exact occupational and drinking-water implementation requirements need jurisdiction-specific review."]},{"article_id":"inorganic-arsenic","title":"Inorganic arsenic: chemical species, water and food, urine testing and threshold limits","words":888,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No household-water assessment, brand ranking or clinical test interpretation is supplied.","Sparse data on some organoarsenic species and individual susceptibility remain important gaps."]},{"article_id":"cadmium","title":"Cadmium: food, smoking, occupational exposure, kidney accumulation and competing intake models","words":893,"questions":6,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personalized whole-diet estimate, workplace compliance assessment or treatment advice is provided.","Interpretation of biomarkers in kidney disease and translation of population models require further clinical appraisal."]},{"article_id":"mercury","title":"Mercury: chemical forms, seafood choices, spills, skin products and testing limits","words":881,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized fish allowance, exposure-test interpretation or chelation advice is supplied.","Contemporary batch variation and location-specific fish advisories require separate evidence."]},{"article_id":"mycotoxins","title":"Mycotoxins: fungal toxins, major families, food testing, processing and diagnostic uncertainty","words":891,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No current brand ranking, complete legal-limit table or clinical diagnostic protocol is supplied.","Mixture effects, modified toxins and generalization from animal studies remain source-specific uncertainties."]},{"article_id":"aflatoxins","title":"Aflatoxins: B1 and M1, food and feed, liver-cancer evidence, sampling and action levels","words":896,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No complete current commodity-specific legal table, brand survey or personal cancer-risk calculation is supplied.","Translation of mixture experiments and species-specific potency assumptions needs further appraisal."]},{"article_id":"3-mcpd","title":"3-MCPD: free and ester forms, sauces and refined oils, intake models and infant context","words":859,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No current formula brand ranking, complete EU legal table or individualized intake calculation is provided.","Clinical developmental evidence, the appropriate interpretation of historical surveys and full current law need further appraisal."]},{"article_id":"glycidyl-esters","title":"Glycidyl esters: refining, glycidol, cancer-hazard evidence, exposure margins and infant nutrition","words":844,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No current formula brand ranking, complete EU numerical table or personal cancer-risk estimate is supplied.","Human outcome evidence, dietary-dose extrapolation and full regulatory applicability require further appraisal."]},{"article_id":"glyphosate","title":"Glyphosate: active substance and formulations, residues, conflicting assessments and newer studies","words":1456,"questions":9,"references":15,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product certification, urine-test diagnosis, lawsuit assessment or personal cancer-risk estimate is supplied.","New assessment conclusions, formulation-specific evidence and independent reappraisal of animal and human studies remain outstanding."]},{"article_id":"radon","title":"Radon: gas and decay particles, home tests, smoking, action levels and mitigation","words":1286,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No building-specific mitigation design, personal cancer probability or device/contractor ranking is supplied.","Local transaction protocols, repeated measurements and post-mitigation performance need building-specific assessment."]},{"article_id":"consumer-vagus-nerve-devices","title":"Consumer vagus nerve devices: nerve targets, clinical indications, and wellness uncertainty","words":894,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term consumer-device effectiveness, optimal clinical selection and product-equivalence evidence remain unresolved."]},{"article_id":"tens-for-pain","title":"TENS for pain: temporary relief, different protocols, and mixed trial results","words":1048,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal electrode placement, stimulation setting, diagnosis or brand recommendation is provided."]},{"article_id":"pemf-devices","title":"PEMF devices: changing magnetic fields, medical uses, and consumer mats","words":811,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No retail-mat comparison, personal exposure setting or conclusion about longevity is supplied."]},{"article_id":"electrical-muscle-stimulation","title":"Electrical muscle stimulation: rehabilitation, whole-body training, and product claims","words":898,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal current setting, suit schedule or unsupervised rehabilitation protocol is supplied."]},{"article_id":"earthing-and-grounding","title":"Earthing and grounding: electrical contact, pilot findings, and unproven health claims","words":768,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Strong independently replicated clinical trials are a substantive evidence gap; source quantity should not hide this limitation.","No wiring, outlet-testing or personal treatment instructions are provided."]},{"article_id":"massage-guns","title":"Massage guns: percussion, flexibility, recovery, and clinical limits","words":924,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal pressure, body placement, treatment duration or brand ranking is provided.","Durable clinical outcomes and adverse-event incidence remain unresolved."]},{"article_id":"hydrogen-water","title":"Hydrogen water: dissolved gas, trial findings, and the limits of wellness claims","words":1027,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Actual retail-device gas delivery, long-term harms, disease prevention and survival effects require further evidence."]},{"article_id":"alkaline-water","title":"Alkaline water: pH, mineral buffering, reflux studies, and hydration claims","words":1006,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal pH target, water volume, ionizer setting or reflux-treatment substitution is supplied."]},{"article_id":"supplemental-oxygen-wellness","title":"Supplemental oxygen for wellness: medical need, performance experiments, and consumer claims","words":751,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal oxygen flow, saturation target, exercise protocol or treatment change is provided.","Direct consumer-product efficacy, durable healthy-person outcomes and cost-benefit remain unresolved."]},{"article_id":"noninvasive-brain-stimulation","title":"Noninvasive brain stimulation: magnetic and electrical methods, clinical treatment, and enhancement claims","words":1054,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.1","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal electrode montage, current, session schedule or brain-region prescription is supplied.","Healthy-person benefit, long-term safety, replication and retail-product equivalence remain separate appraisal gaps."]},{"article_id":"independent-certification","title":"Independent certification: product seals, laboratory accreditation and the scope of a claim","words":1307,"questions":11,"references":13,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which schemes independently evaluate the attributes that consumers assume from their seals?","How consistently do ongoing audits detect batch changes and advertising outside the certified scope?"]},{"article_id":"regulatory-versus-health-based-thresholds","title":"Regulatory and health-based thresholds: legal limits, exposure guidance and warning levels","words":900,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do updated health assessments change the interpretation of older compliance reports?","Which exposure assumptions and decision rules underlie a specific product comparison?"]},{"article_id":"measurement-uncertainty","title":"Measurement uncertainty: estimates, error bars, traceability and decisions near a limit","words":1017,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which uncertainty components are included in the specific report, and which are outside its scope?","How should a stated conformity rule allocate false-acceptance and false-rejection risks for the intended use?"]},{"article_id":"representative-sampling","title":"Representative sampling: batches, pooled samples, chain of custody and limits of a test","words":949,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Does the report identify the precise lot and selection process needed for its advertised conclusion?","How much of the uncertainty comes from sampling rather than analysis for the relevant product?"]},{"article_id":"gas-stoves","title":"Gas stoves: combustion, cooking particles and useful ventilation","words":818,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual long-term health benefits of specific household changes need more clinical outcome trials."]},{"article_id":"indoor-vocs","title":"Indoor VOCs: gases, total readings and misleading low-VOC labels","words":870,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Real-room gas removal varies by chemical, media quantity, source rate and maintenance."]},{"article_id":"dust-mites","title":"Dust mites: allergens, bedding and why control results differ","words":818,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which sustained combinations best improve clinical outcomes across climates and patient groups remains uncertain."]},{"article_id":"pet-allergens","title":"Pet allergens: fur, proteins, air cleaning and breed claims","words":1065,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Real-world clinical benefit of particular combinations of pet exposure controls needs better outcome evidence."]},{"article_id":"household-pest-control","title":"Household pest control: prevention, baits, sprays and cleanup","words":903,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative exposure and effectiveness vary by pest, building, formulation and resistance; not a product ranking."]},{"article_id":"wildfire-smoke","title":"Wildfire smoke: particles, clean rooms and ventilation tradeoffs","words":964,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal long-term risks and real-world benefits of particular filters are not quantified by this educational overview."]},{"article_id":"home-ventilation","title":"Home ventilation: fresh air, exhaust, filters and carbon dioxide","words":959,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["A specific home’s needed airflow and system changes require its building, occupancy, climate and sources to be assessed."]},{"article_id":"water-filter-maintenance","title":"Water filter maintenance: replacement, cleaning and claim boundaries","words":752,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No universal cartridge schedule or cleaning recipe is appropriate across all models, source waters and contaminants."]},{"article_id":"essential-oil-diffusers","title":"Essential oil diffusers: scent, emissions and realistic health claims","words":799,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term household disease risk by oil, device, duration and user susceptibility remains incompletely quantified."]},{"article_id":"hypoallergenic-claims","title":"Hypoallergenic claims: cosmetics, allergy tests and pet labels","words":1262,"questions":8,"references":12,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["There is no universally applicable product ranking for personal allergy tolerance; comparison data for current formulations are limited."]},{"article_id":"mouthwash","title":"Mouthwash: cosmetic rinses, fluoride, antiseptics and the oral microbiome","words":701,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual dental indications, duration and formulation selection require dental assessment.","Long-term systemic outcomes for each retail formulation are not resolved here."]},{"article_id":"toothbrushing","title":"Toothbrushing: manual and powered brushes, fluoride and interdental cleaning","words":759,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual technique, interdental fit and prescribed fluoride strength require dental advice.","Modern device-model comparisons and lasting clinical outcomes are not comprehensively reviewed."]},{"article_id":"moisturizers","title":"Moisturizers: humectants, emollients, occlusion and skin-barrier claims","words":772,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal moisturizer selection, patch testing and eczema treatment changes are not supplied.","No universal ranking of moisturizer brands or prevention regimen is established."]},{"article_id":"topical-retinoids","title":"Topical retinoids: cosmetic retinol, acne medicines and photoaging evidence","words":1234,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal dosing, prescription changes and pregnancy exposure assessment are not provided.","Retail cosmetic equivalence, brand rankings and whole-body rejuvenation are not established."]},{"article_id":"hair-care-products","title":"Hair care products: cleansing, conditioning, scalp treatment and breakage","words":796,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized wash schedule, allergy diagnosis or hair-loss treatment is prescribed.","Claims about a retail formulation’s growth, repair or heat protection need product-specific outcome evidence."]},{"article_id":"hair-straightening-products","title":"Hair straightening products: relaxers, smoothing treatments and distinct exposure risks","words":766,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No safe-brand ranking, personal cancer estimate or home straightening instructions are supplied.","Kidney-injury incidence, responsible formulations and evolving jurisdiction-specific restrictions require further appraisal."]},{"article_id":"menstrual-products","title":"Menstrual products: absorbent and collecting options, safe use and contaminant evidence","words":780,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized device fitting, brand ranking or blood-metal interpretation is supplied.","Product-specific absorption, cumulative exposure and long-term outcomes require further investigation."]},{"article_id":"intimate-care-products","title":"Intimate care products: external washing, douching, lubrication and microbiome claims","words":789,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individual discharge diagnosis, antibiotic selection or microbiome-treatment prescription is provided.","Ingredient-specific mucosal safety and claims for retail washes require formulation-specific evidence."]},{"article_id":"clean-beauty-claims","title":"Clean beauty claims: natural, organic, free-from and allergy labels","words":1246,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual allergen avoidance requires a confirmed exposure and clinical assessment.","No retailer exclusion list, clean score or certification is treated as proof of superior health outcomes."]},{"article_id":"clothing-and-textiles","title":"Clothing and textiles: fibers, finishes, skin reactions and functional claims","words":827,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individual rash diagnosis, safe-brand ranking or full garment-exposure assessment is supplied.","Environmental impacts, occupational textile exposures and infection-prevention claims are not comprehensively reviewed."]},{"article_id":"infant-formula","title":"Infant formula: product types, preparation, storage, and what regulation means","words":1006,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized product choice, feeding-volume prescription, allergy diagnosis or emergency-water recipe is supplied.","Comparative developmental benefits of retail brands are not established by this selective overview."]},{"article_id":"complementary-foods","title":"Complementary foods: readiness, textures, nutrients, and why recommendations differ","words":891,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal allergen challenge, feeding-volume schedule or prematurity timetable is generated.","Texture, nutritional adequacy and developmental readiness require individual assessment when feeding is difficult."]},{"article_id":"baby-food","title":"Baby food: purées, pouches, textures, contaminants, and safe storage","words":969,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal contaminant dose, batch-safety guarantee or infant-feeding prescription is generated.","Product-specific nutrient content and contamination require the actual label and appropriately interpreted testing."]},{"article_id":"picky-eating","title":"Picky eating: ordinary selectivity, feeding disorders, growth, and practical approaches","words":779,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individual feeding diagnosis, supplement plan, forced-exposure schedule or allergy elimination diet is generated.","Persistent restriction, developmental differences, prematurity and swallowing difficulty may require tailored multidisciplinary assessment."]},{"article_id":"growth-charts","title":"Growth charts: percentiles, trajectories, prematurity, and what a change means","words":799,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal percentile diagnosis, growth-faltering cause or calorie prescription is generated.","Local charts, developmental conditions and individualized preterm follow-up can require separate interpretation."]},{"article_id":"childhood-fever","title":"Fever in children: temperature, age, comfort, and urgent warning signs","words":838,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal diagnosis, triage clearance, antibiotic decision or weight-based antipyretic dose is generated.","Prematurity, immunocompromise, complex disease and ill appearance require pathways beyond the well-infant algorithm."]},{"article_id":"child-car-seats","title":"Child car seats: restraint stages, belt fit, installation, and crash history","words":1037,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal seat-fit certification, local legal compliance determination or manufacturer-specific installation recipe is supplied.","Prematurity, medical positioning needs and adapted transport require professional individualized advice."]},{"article_id":"choking-prevention","title":"Choking prevention: food shape, small objects, swallowing hazards, and emergency recognition","words":863,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No remote assurance that an airway is clear, ingestion triage clearance or substitute for practical CPR training is supplied.","Children with swallowing disorders, prematurity or developmental differences may need individualized texture and feeding assessment."]},{"article_id":"child-sleep-routines","title":"Child sleep routines: age, bedtime habits, tested methods, and caregiver wellbeing","words":1107,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No individualized newborn training method, night-feed reduction, medication or melatonin dosing plan is supplied.","Prematurity, feeding needs, neurodevelopmental differences and breathing symptoms require individualized assessment."]},{"article_id":"screen-time-and-children","title":"Screens and children: age, content, context, displacement, and what research can show","words":895,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No personal developmental diagnosis, ADHD causation attribution, universal hourly prescription or mental-health treatment plan is generated.","Accessibility, schooling, neurodevelopment, platform design and lasting intervention effects need separate assessment."]},{"article_id":"running","title":"Running: pace, training exposure, health associations, and injury uncertainty","words":960,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"cycling","title":"Cycling: commuting, indoor riding, fitness, and the meaning of health claims","words":918,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"swimming","title":"Swimming: strokes, aquatic exercise, training outcomes, and water safety","words":879,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"rucking","title":"Rucking: loaded walking, energy cost, equipment, and limits of military evidence","words":834,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"weighted-vests","title":"Weighted vests: added load, walking, bone findings, and body-composition claims","words":1244,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"blood-flow-restriction-training","title":"Blood-flow-restriction training: cuffs, low loads, rehabilitation, and safety limits","words":969,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"training-to-failure","title":"Training to failure: set endings, repetitions in reserve, muscle growth, and fatigue","words":864,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"concurrent-training","title":"Concurrent training: combining endurance and strength, interference, and distinct outcomes","words":858,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"fasted-exercise","title":"Fasted exercise: meal timing, fuel use, performance, and limits of fat-loss claims","words":882,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"balance-training","title":"Balance training: static, dynamic and reactive skills, fall outcomes, and transfer","words":1097,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false,"supplemental_depth1_checked_at":"2026-10-20"},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Personal exercise programming, suitability with medical conditions, and return after injury require individual assessment.","Long-term outcomes and understudied populations may differ from the selected protocols."]},{"article_id":"dizziness","title":"Dizziness: spinning, faintness, timing, triggers and assessment","words":712,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"fainting","title":"Fainting: syncope, warning patterns, first aid and investigation","words":763,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"fever","title":"Fever: temperature measurements, infection, age and warning signs","words":724,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"cough","title":"Cough: dry and productive symptoms, duration and treatment limits","words":743,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"sore-throat","title":"Sore throat: pharyngitis, strep testing and antibiotic decisions","words":812,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"nausea-and-vomiting","title":"Nausea and vomiting: symptom patterns, dehydration and cause-specific care","words":749,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"bloating","title":"Bloating: fullness, visible distension, gas and competing treatment advice","words":850,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"palpitations","title":"Palpitations: heartbeat awareness, rhythm categories and monitoring","words":798,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"chest-pain","title":"Chest pain: urgent discomfort, angina patterns and diagnostic limits","words":797,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"shortness-of-breath","title":"Shortness of breath: breathing sensations, patterns, tests and urgent changes","words":775,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The exact cause and appropriate management of an individual symptom episode require clinical assessment.","Independent medical review and exhaustive evidence synthesis remain pending."]},{"article_id":"bisphenol-a","title":"Bisphenol A and other bisphenols: food contact, replacement chemicals and competing assessments","words":1394,"questions":9,"references":12,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"phthalates","title":"Phthalates: plasticizers, food pathways, cosmetics and cumulative exposure","words":786,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"pfas","title":"PFAS: chemical families, food and water exposure, testing and evolving rules","words":1194,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"formaldehyde","title":"Formaldehyde: gas, formalin, household emissions, salon exposure and cancer evidence","words":1048,"questions":7,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"benzene","title":"Benzene: air, fuel, product contamination and the importance of validated testing","words":836,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"ochratoxin-a","title":"Ochratoxin A: storage fungi, coffee and cereals, kidney hazard and changing risk assessments","words":826,"questions":6,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"fumonisins","title":"Fumonisins: corn contamination, B-type forms, intake guidance and human-evidence limits","words":780,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"deoxynivalenol","title":"Deoxynivalenol: vomitoxin, modified forms, wheat products and urinary exposure studies","words":862,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"zearalenone","title":"Zearalenone: a fungal estrogen, modified forms, grain exposure and biomarker limits","words":748,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"patulin","title":"Patulin: apple spoilage, juice processing, action levels and testing quality","words":839,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.2","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No product-specific safety certificate or individualized exposure diagnosis is provided.","Jurisdiction-specific implementation, sampling methods and newly published evidence require separate assessment."]},{"article_id":"medical-records","title":"Medical records: portals, copies, corrections, results and privacy after sharing","words":1011,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which information is absent from a particular portal and needed for a specific care decision?","How can services provide timely access and understandable explanation without widening inequity?"]},{"article_id":"telehealth","title":"Telehealth: video, phone, messages, monitoring and when remote care fits","words":994,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which patients and clinical tasks can safely use a remote format as a replacement rather than added support?","How should services measure accessibility, continuity and total costs alongside clinical outcomes?"]},{"article_id":"second-opinions","title":"Second opinions: independent review, diagnostic differences, preparation and limits","words":929,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which second-opinion pathways improve patient-important outcomes rather than only changing recommendations?","How can access and timeliness be improved without delaying necessary care?"]},{"article_id":"referrals","title":"Referrals: clinical requests, insurance rules, specialist advice and closing the loop","words":968,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which coordination interventions reliably improve timely completion and patient-important outcomes?","How should health systems distinguish appropriate avoidance of a visit from a missed necessary referral?"]},{"article_id":"ketogenic-diets","title":"Ketogenic diets: ketosis, medical therapy and consumer keto","words":773,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"low-carbohydrate-diets","title":"Low-carbohydrate diets: definitions, replacements and comparative evidence","words":785,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"low-fat-diets","title":"Low-fat diets: total fat, fat quality and what replaces it","words":807,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"dash-diet","title":"DASH diet: a food pattern, sodium reduction and blood-pressure evidence","words":774,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"carnivore-diet","title":"Carnivore diet: animal-only variants, reported benefits and unanswered safety questions","words":773,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"anti-inflammatory-diet-claims","title":"Anti-inflammatory diet claims: biological responses, scores and clinical outcomes","words":1115,"questions":7,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"fasting-mimicking-diets","title":"Fasting-mimicking diets: periodic low-energy eating and what the human trials measured","words":784,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"sustainable-diets","title":"Sustainable diets: nutrition, environmental impacts, cost and cultural fit","words":947,"questions":7,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"cultural-dietary-patterns","title":"Cultural dietary patterns: traditional foods, adaptation and what research labels mean","words":814,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"food-fortification","title":"Food fortification: added nutrients, population programs and label interpretation","words":989,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual diet choice, medicine adjustment and nutrition adequacy require assessment beyond this educational overview.","Long-term comparative clinical outcomes and feasibility in underrepresented populations remain incompletely resolved."]},{"article_id":"matcha","title":"Matcha: powdered tea, caffeine, product grades and the limits of brain-health claims","words":787,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which independent longer trials confirm meaningful cognitive outcomes?","How do measured compounds vary across prepared servings and batches?"]},{"article_id":"spices","title":"Spices: seasoning, culinary doses, concentrated products and food-safety limits","words":758,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which culinary mixtures have reproducible long-term effects beyond short trials?","How do routine seasoning and concentrated products compare at matched exposures?"]},{"article_id":"food-additives","title":"Food additives: functions, approval pathways, E numbers and changing evidence","words":1161,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How well do current exposure estimates capture combinations and high consumers?","Which assessments require additional independent human data?"]},{"article_id":"genetically-modified-foods","title":"Genetically modified foods: methods, traits, safety assessment and what labels mean","words":817,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How should new traits be assessed as technologies and exposure patterns change?","Which agricultural tradeoffs are specific to traits and local farming practices?"]},{"article_id":"food-matrix","title":"Food matrix: why structure and preparation matter alongside nutrients","words":798,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which matrix measures predict meaningful outcomes across foods?","How can longer trials separate structure from composition, eating speed and palatability?"]},{"article_id":"lectins-in-cooked-foods","title":"Lectins in cooked foods: raw-bean hazards, preparation and exaggerated avoidance claims","words":804,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which standardized activity measures predict human risk after normal cooking?","How should risks from less-studied lectins be assessed without unnecessary broad restrictions?"]},{"article_id":"food-budgets","title":"Food budgets: useful comparisons, realistic constraints and affordable meal choices","words":801,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How should affordability measures incorporate time, equipment and transportation?","Which supports improve access when a household’s available income remains insufficient?"]},{"article_id":"food-insecurity","title":"Food insecurity: reliable access, severity, measurement and routes to support","words":1086,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which combinations of income, transport and benefit support most reliably improve access?","How can survey methods better describe unequal experiences within households?"]},{"article_id":"food-waste","title":"Food waste: prevention, storage, date labels and safety before salvage","words":868,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which household interventions remain effective under limited time and storage?","How can measurements separate preventable edible waste from inedible or unsafe material?"]},{"article_id":"food-preparation-skills","title":"Food preparation skills: practical competence, confidence and what classes can change","words":1149,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which program components produce durable objectively measured changes?","How can training be combined with equipment, access and financial support?"]},{"article_id":"contact-lenses","title":"Contact lenses: materials, wear schedules, cleaning systems and eye-infection risk","words":746,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual fitting, solution compatibility and symptom diagnosis require eye care.","The relative infection risk of every current material and replacement system is not resolved here."]},{"article_id":"hearing-aids","title":"Hearing aids: styles, OTC eligibility, self-fitting evidence and communication limits","words":822,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual hearing assessment, fitting and treatment selection are outside this reference.","Long-term outcomes and usability of every OTC interface remain unresolved."]},{"article_id":"earwax","title":"Earwax: normal protection, impaction, removal methods and uncertain treatment comparisons","words":823,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Diagnosis and safe removal depend on examination and eardrum status.","Head-to-head comparisons of current products and home devices remain incomplete."]},{"article_id":"nasal-irrigation","title":"Nasal irrigation: saline types, delivery methods, symptom evidence and water safety","words":707,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["An individual’s diagnosis, immune status and suitability for rinsing require clinical judgment.","Long-term comparisons of current volumes, concentrations and devices remain incomplete."]},{"article_id":"shaving-and-hair-removal","title":"Shaving and hair removal: cutting, pulling, dissolving, laser treatment and avoidable injuries","words":845,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual suitability of chemical or energy-based removal is outside this page.","Direct comparisons of every home device, material and skin tone remain incomplete."]},{"article_id":"tattoos","title":"Tattoos: injected pigment, infection, allergic reactions, removal and uncertain long-term risk","words":844,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual skin reactions and removal decisions require clinical assessment.","Long-term pigment-specific causal risks and exposure dose remain incompletely established."]},{"article_id":"piercing-aftercare","title":"Piercing aftercare: healing sites, jewelry materials, infection and conflicting cleaning advice","words":854,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Diagnosis of infection versus allergy and decisions about jewelry removal need clinical assessment.","Comparative trials of site-specific cleaning and movement routines are not synthesized here."]},{"article_id":"bathing","title":"Bathing: hygiene needs, skin barriers, infant safety and the eczema-frequency debate","words":1025,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["An individual eczema regimen and bathing adaptations for disability need appropriate care advice.","Longer-term frequency trials and direct comparisons of cleanser routines remain limited."]},{"article_id":"insect-bite-prevention","title":"Insect-bite prevention: repellents, treated clothing, tick checks and product-specific age limits","words":916,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Individual pediatric suitability and destination-specific disease prevention need appropriate advice.","Current labels and local vector conditions must be checked for a specific product or trip."]},{"article_id":"hearing-protection","title":"Hearing protection: earplug fit, earmuff seals, noise ratings and safe-listening limits","words":823,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Workplace exposure assessment, pediatric fit and individual hearing symptoms require appropriate professional assessment.","Long-term protection from every fit-testing protocol or consumer device is not established here."]},{"article_id":"rash","title":"Rash: skin changes, competing causes and when assessment is urgent","words":711,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"itching","title":"Itching: skin, nerve and systemic causes, with or without a rash","words":752,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"numbness-and-tingling","title":"Numbness and tingling: temporary pressure, nerve patterns and urgent warning signs","words":728,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"weakness","title":"Weakness: reduced power, fatigue and where the problem may arise","words":776,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"tremor","title":"Tremor: rhythmic shaking, activation patterns and competing explanations","words":707,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"swelling","title":"Swelling: tissue fluid, lymphatic drainage and patterns that need urgent care","words":741,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"night-sweats","title":"Night sweats: overheating, drenching episodes and what the pattern can mean","words":720,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"unintentional-weight-loss","title":"Unintentional weight loss: changes in intake, absorption and illness","words":741,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"palpable-lumps","title":"Palpable lumps: skin growths, cysts, lymph nodes and what examination can establish","words":727,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"abdominal-pain","title":"Abdominal pain: location, changing patterns and limits of symptom-based reassurance","words":690,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment is appropriate for an individual presentation?","Which explanation fits after examination and follow-up?"]},{"article_id":"liver-tests","title":"Liver tests: enzymes, bilirubin, proteins and what a liver panel can tell you","words":1318,"questions":8,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which abnormal patterns require prompt investigation in the person’s actual clinical context?","How should discordant enzymes, clotting results and imaging be reconciled?"]},{"article_id":"kidney-tests","title":"Kidney tests: creatinine, estimated filtration, urine albumin and why results differ","words":1311,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.3","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which marker or measured filtration method is most useful when estimates disagree?","How much of a change reflects illness, measurement variation or a persistent condition?"]},{"article_id":"urine-tests","title":"Urine tests: urinalysis, dipsticks, cultures and collecting the right 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should bed insulation, humidity and individual sensitivity be measured together?"]},{"article_id":"bedding-and-sleep","title":"Bedding and sleep: fabrics, thermal properties, mattresses and comfort evidence","words":962,"questions":8,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.4","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which fabric constructions work across ordinary home conditions?","Do reported cooling benefits persist in randomized trials with objective sleep measurements?"]},{"article_id":"light-at-night","title":"Light at night: brightness, spectrum, timing and limits of screen-filter 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interactions alter suitability for a particular person?"]},{"article_id":"antihistamines","title":"Antihistamines: generations, routes, drowsiness and OTC suitability","words":954,"questions":7,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.4","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which product best fits an individual’s symptoms, conditions and medicines?","What is the frequency and best management of ingredient-specific cessation itching?"]},{"article_id":"decongestants","title":"Decongestants: oral ingredients, nasal sprays, rebound and phenylephrine status","words":841,"questions":6,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.4","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How clinically useful are 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product labeling?"]},{"article_id":"travelers-diarrhea","title":"Travelers’ diarrhea: infection, severity, hydration and competing prevention evidence","words":813,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which preventive strategies have the best benefit-harm balance for defined high-risk travelers?","Which modern diagnostics improve outcomes for persistent symptoms rather than merely detecting organisms?"]},{"article_id":"cuts-and-scrapes","title":"Cuts and scrapes: cleaning, covering and recognizing wounds needing care","words":746,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which 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remain incompletely assessed; qualified review is pending."]},{"article_id":"adhesive-bandages-and-dressings","title":"Adhesive bandages and dressings: wound contact, moisture and skin protection","words":825,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which covering and change interval fit this wound and the surrounding skin?","Contemporary minor-injury comparisons and qualified review remain incomplete."]},{"article_id":"topical-antibiotics","title":"Topical antibiotics: first-aid ointments, infection prevention and contact 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pressure problem and footwear does the proposed device address?","Long-term device-specific comparisons, disease-associated childhood indications and qualified review remain incomplete."]},{"article_id":"kinesiology-tape","title":"Kinesiology tape: elastic support, sham comparisons and uncertain benefits","words":828,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Does tape add a meaningful benefit to the rehabilitation plan for this condition?","Long-term function, healing and reliable harms data remain limited; qualified review is pending."]},{"article_id":"artificial-tears","title":"Artificial tears: lubricant formulations, preservatives and trial 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occupations?"]},{"article_id":"screen-related-eye-strain","title":"Screen-related eye strain: dryness, focusing demands and break-rule evidence","words":859,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What is the most useful break strategy for different tasks?","Which findings persist in longer, independently replicated trials?"]},{"article_id":"eye-health-supplements","title":"Eye health supplements: assessed AMD indications, formulas and wellness claims","words":846,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessed AMD stage warrants a formula discussion?","How do formulation, background diet and long-term adherence alter benefit and harm?"]},{"article_id":"vision-training-claims","title":"Vision training claims: convergence therapy, reading outcomes and myopia exercises","words":849,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do adult or post-concussion indications compare?","Which novel programs improve meaningful outcomes in independently replicated trials?"]},{"article_id":"contact-lens-solutions","title":"Contact lens solutions: cleaning, disinfection, saline and peroxide systems","words":870,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which system is compatible with a person’s lens and eye?","How well do laboratory rankings predict infection outcomes during ordinary use?"]},{"article_id":"cosmetic-contact-lenses","title":"Cosmetic contact lenses: appearance changes, fitting and infection evidence","words":839,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What is current population-based infection incidence by verified product and care practice?","How do manufacturing, access, fitting and behavior independently contribute?"]},{"article_id":"eye-makeup-and-hygiene","title":"Eye makeup and hygiene: application sites, contamination and ingredient 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formulation?","How will the 2026 consultation affect future cross-contact information?"]},{"article_id":"non-gmo-labels","title":"Non-GMO labels: voluntary claims, bioengineered disclosure and safety assessment","words":763,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What sourcing or testing criteria does a particular private label use?","Which product-specific assessment supports a claimed nutritional or environmental difference?"]},{"article_id":"plant-based-food-labels","title":"Plant-based food labels: ingredients, nutrient comparisons and allergy 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relevant population?"]},{"article_id":"whole-grain-labels","title":"Whole-grain labels: retained grain parts, ingredient quantities and misleading shortcuts","words":1207,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What whole-grain proportion does the specific manufacturer’s formulation establish?","How consistently do shoppers distinguish composition from milling and variety claims?"]},{"article_id":"sugar-free-and-no-added-sugar-labels","title":"Sugar-free and no-added-sugar labels: total sugars, sweeteners and claim 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diet?"]},{"article_id":"reduced-fat-food-labels","title":"Reduced-fat food labels: reference products, light wording and calorie comparisons","words":824,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which reference food and portion basis support the actual reduction?","What ingredients replace fat, and do studies of that substitution show the intended health outcome?"]},{"article_id":"antacids","title":"Antacids: neutralizing acid, ingredient differences and combination products","words":976,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which particular formulations improve meaningful symptoms in which populations?","What product-specific interactions and causes of persistent symptoms require assessment?"]},{"article_id":"acid-suppressing-medicines","title":"Acid-suppressing medicines: H2 blockers, PPIs and short versus continuing treatment","words":867,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which patients have a continuing documented indication and what follow-up is appropriate?","How large are rare long-term harms in populations outside available randomized trials?"]},{"article_id":"motion-sickness-medicines","title":"Motion-sickness medicines: antihistamine tablets, scopolamine patches and sedation","words":957,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What medicines meaningfully treat established symptoms rather than prevent their onset?","How do benefit, alertness and anticholinergic harms compare in older adults and children?"]},{"article_id":"nasal-corticosteroid-sprays","title":"Nasal corticosteroid sprays: inflammation control, delivery and product boundaries","words":924,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do specific devices and preparations compare in useful symptom control and adherence?","What evidence supports long-term use in populations less represented in trials?"]},{"article_id":"antifungal-medicines","title":"Antifungal medicines: skin, scalp, nail and oral treatment are different contexts","words":858,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do organism, site and resistance affect comparative treatment outcomes?","Which treatments improve recurrence and quality of life rather than laboratory cure alone?"]},{"article_id":"medicated-acne-products","title":"Medicated acne products: active ingredients, formulations and measured outcomes","words":899,"questions":6,"references":7,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which ingredient combinations improve outcomes important to particular patients with acceptable irritation?","How can evidence about scars, quality of life and serious adverse effects be improved?"]},{"article_id":"wart-removal-products","title":"Wart-removal products: salicylic acid, home freezing and clinical comparisons","words":840,"questions":6,"references":6,"depth_status":{"status":"expanded_explainer","edition":"4.5","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do contemporary consumer freezing devices compare with labeled salicylic preparations?","Which outcomes matter beyond disappearance, including pain, recurrence and pigment change?"]},{"article_id":"otc-sleep-aids","title":"OTC sleep aids: sedating antihistamines, labels and the limits of short-term 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activity units, cardiovascular surrogate trials and bleeding concerns","words":1181,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.7","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Do well-designed trials establish net clinical-event benefit while quantifying bleeding?","Which preparations have reliable active-enzyme exposure and reproducible activity assays?","What are interactions and safety in higher-risk patients, pregnancy, childhood and perioperative care?"]},{"article_id":"spermidine","title":"Spermidine: polyamines, extract and purified forms, autophagy biology, mortality associations and a negative memory 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populations?","How should communication supports be adapted and evaluated?","How transferable are school and university trial findings?","How do current local age, capacity and reporting rules apply to an individual situation?"]},{"article_id":"parenting-support","title":"Parenting support: developmental stages, positive discipline, tested programmes and caregiver wellbeing","words":1250,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which programme best fits a particular developmental stage, disability and cultural context?","How durable are effects when support ends?","How can access barriers and reporting differences be addressed?","Which structural supports most improve caregiver and child wellbeing?"]},{"article_id":"separation-and-divorce","title":"Separation and divorce: health, children’s adjustment, family context and safe support","words":1067,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which supports work for particular family circumstances and cultural contexts?","How much of observed health risk reflects prior vulnerability, resources or the transition itself?","How durable and transferable are parenting-programme effects?","What legal and safety arrangements fit the local jurisdiction and individual family?"]},{"article_id":"relationship-communication","title":"Relationship communication: listening, expressing needs, education evidence and safety limits","words":1144,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which skills themselves explain program effects rather than broader support?","How durable are effects across relationship types and circumstances?","How well are neurodivergent, disabled and LGBTQ+ participants represented?"]},{"article_id":"relationship-conflict","title":"Relationship conflict: disagreements, demand–withdraw patterns, counseling evidence and abuse distinctions","words":1088,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which contextual factors reliably modify conflict-strategy effects?","Who benefits or does not respond over several years?","How can research include diverse relationships without erasing coercion and safety differences?"]},{"article_id":"relationship-boundaries","title":"Relationship boundaries: personal limits, expectations, consent, privacy and evidence gaps","words":1055,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which boundary-teaching approaches have controlled evidence for meaningful outcomes?","How do culture, disability and dependency change the feasibility of expressing limits?","How can research distinguish negotiated privacy from fear-driven silence?"]},{"article_id":"intimate-partner-violence","title":"Intimate partner violence: forms of abuse, health effects, confidential support and intervention limits","words":1248,"questions":9,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which services are locally accessible and safe to contact?","How well do these interventions work for men, gender-diverse survivors and people with disabilities?","Which sustained programmes reduce repeat violence without unintended harms?"]},{"article_id":"coercive-control","title":"Coercive control: patterns of domination, constrained autonomy, health effects and safety-aware support","words":1118,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can services assess cumulative control with validated and inclusive measures?","Which interventions improve autonomy and safety over sustained follow-up?","How do local legal developments affect available remedies and unintended consequences?"]},{"article_id":"sexual-violence","title":"Sexual violence: consent, forms of harm, time-sensitive clinical care, forensic choices and recovery evidence","words":1109,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which local services are accessible without requiring a police report, and what safeguarding exceptions apply?","Which approaches provide sustained recovery outcomes for underrepresented survivors?","How can studies reliably capture adverse effects, attrition and outcomes important to survivors?"]},{"article_id":"safeguarding","title":"Safeguarding: child and adult thresholds, forms of abuse, person-directed protection and jurisdiction-specific reporting","words":1337,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.9","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which official local route and reporting duty applies to the person and concern?","How can safeguarding preserve autonomy while responding to coercion and impaired protection?","How consistently are new information-sharing duties and APS standards implemented?"]},{"article_id":"prenatal-care","title":"Prenatal care: appointments, screening choices, medicines and tailored support","words":1090,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which modern care schedules preserve outcomes and improve experience across resource settings?","Which tasks can safely be delivered remotely for each risk group?","How can services address access barriers and ensure result follow-up?","Which screening and prevention options fit an individual history and local pathway?"]},{"article_id":"birth-choices","title":"Birth choices: setting, mode, timing, pain relief, support and changing plans","words":1362,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How well do dated setting comparisons apply to a particular modern local service?","What are outcomes and experience with induction in groups excluded from ARRIVE?","How do rare analgesia risks and long-term outcomes compare?","Which support models provide accessible, respectful care across different settings?"]},{"article_id":"pregnancy-loss","title":"Pregnancy loss: miscarriage, stillbirth, recurrent loss, assessment and support","words":1195,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which evaluation changes care for a particular loss history?","How do management outcomes vary outside the confirmed early missed-loss trial?","Which support interventions are most useful to individuals and partners?","How should local definitions, access and reporting requirements be explained sensitively?"]},{"article_id":"newborn-examination-and-screening","title":"Newborn examination and screening: physical checks, blood spots, hearing, heart tests and follow-up","words":1229,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do current hip-screening strategies affect late diagnosis and unnecessary treatment?","How do specimen and follow-up systems affect real-world benefits?","How consistently are programmes implemented across places and medically complex newborns?"]},{"article_id":"neonatal-jaundice","title":"Neonatal jaundice: bilirubin, timing, measurement, treatment thresholds and evidence limits","words":1325,"questions":11,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How reliably do current threshold pathways prevent rare neurologic injury across settings?","Which follow-up systems reduce missed deterioration without unnecessary treatment?","Is any selected IVIG subgroup helped in robust trials?"]},{"article_id":"prematurity","title":"Prematurity: gestational-age groups, neonatal care, trial findings and developmental follow-up","words":1285,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do supportive-care effects transfer across gestational groups and resource settings?","Which feeding and respiratory approaches optimize multiple outcomes together?","How can developmental follow-up remain accessible and responsive to family needs?"]},{"article_id":"adolescent-confidential-care","title":"Adolescent confidential care: private visits, consent, legal limits, records and evidence gaps","words":1162,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which truthful explanations of privacy limits improve actual access and health outcomes?","How can portals support safe caregiver involvement while protecting legally confidential data?","How do disability, language, dependency and coercion alter privacy needs and feasible support?"]},{"article_id":"preeclampsia","title":"Preeclampsia: pregnancy hypertension categories, warning symptoms, placental tests, delivery trade-offs and postpartum follow-up","words":1246,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which tests improve outcomes in the local care pathway rather than accuracy alone?","Which pregnancies benefit from delivery at each gestational age?","What follow-up best supports cardiovascular and emotional health after affected pregnancies?"]},{"article_id":"ectopic-pregnancy","title":"Ectopic pregnancy: implantation sites, pregnancy of unknown location, urgent symptoms, follow-up and treatment evidence","words":1030,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which diagnostic follow-up is safest while pregnancy viability remains uncertain?","How do monitoring and treatment compare for populations excluded from selected trials?","What care supports both future pregnancy planning and emotional recovery?"]},{"article_id":"hyperemesis-gravidarum","title":"Hyperemesis gravidarum: severe pregnancy sickness, impaired intake, assessment, supportive care and uncertain treatment comparisons","words":1100,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.10","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which contemporary definitions best support recognition without delaying care?","Which interventions are more effective and tolerable for defined severity groups?","How can studies distinguish effects of illness, treatment, nutrition and confounding on later outcomes?"]},{"article_id":"workplace-accommodations","title":"Workplace accommodations: disability, job barriers, individual adjustments, confidentiality and employment evidence","words":1295,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which adjustments improve long-term participation and retention in defined jobs?","How do worker-reported and employer-reported effectiveness differ?","Which local legal protections, funding conditions and appeal routes apply?"]},{"article_id":"accessible-healthcare","title":"Accessible healthcare: physical equipment, communication, service adjustments, supported decisions and evidence gaps","words":1091,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which local services and equipment actually meet the individual’s needs?","Which changes improve meaningful participation and clinical outcomes in defined populations?","How do consent, information sharing and legal coverage apply to the actual decision and provider?"]},{"article_id":"disability-secondary-health-needs","title":"Disability and secondary health needs: co-occurring conditions, preventive care, pain, skin and condition-specific assessment","words":1250,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which needs arise in this individual rather than being assumed from a disability label?","Which checks and support strategies improve patient-important outcomes in defined groups?","How can services detect treatable new symptoms while respecting communication preferences and agency?"]},{"article_id":"adapted-exercise","title":"Adapted exercise: activity options, individual goals and condition-specific evidence","words":1120,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which adaptations support sustained participation among people excluded from many trials?","How do short-term fitness changes translate into long-term disease and daily-life outcomes?","How can trials report harms, accessibility and individual goals more consistently?"]},{"article_id":"wheelchair-seating-and-skills","title":"Wheelchair seating and skills: fit, controls, training and participation","words":1297,"questions":11,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which service arrangements sustain useful fit, maintenance and follow-up?","How do skills gains affect participation among less-studied ages, diagnoses and support needs?","How do cushion and seating comparisons perform across different environments and longer follow-up?"]},{"article_id":"augmentative-alternative-communication","title":"Augmentative and alternative communication: tools, access, user control and evidence","words":1279,"questions":11,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which forms and access methods support the user’s own communication across changing contexts?","How do communication interventions affect meaningful adult participation and long-term outcomes?","How can trials and service pathways include people poorly represented in current evidence?"]},{"article_id":"rehabilitation-services","title":"Rehabilitation services: teams, settings, referral, access and delivery evidence","words":1077,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which referral and information systems reduce inequitable delay or unmet need?","How do delivery models perform for populations excluded from stroke and SCI studies?","How can services preserve user goals and coordination across hospital, home and community transitions?"]},{"article_id":"transgender-health","title":"Transgender health: primary care, treatment choices, fertility and age-specific evidence","words":1253,"questions":9,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which treatment fits a particular person’s goals and medical circumstances?","How do adolescent outcomes vary by age, development, regimen and accompanying care?","What are the longer-term benefits and harms of specific hormone preparations and puberty suppression?","How can current local access and follow-up arrangements be explained without confusing policy and evidence?"]},{"article_id":"intersex-health","title":"Intersex health: distinct variations, medical needs, consent and lifelong support","words":1199,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which medical needs follow from a particular variation and prior treatment?","How can nonurgent options and consent be explained without pressure or stigma?","How do long-term patient-reported outcomes vary by procedure, timing and diagnosis?","Which practical, psychological and peer supports are most helpful across life stages?"]},{"article_id":"geriatric-care-assessment","title":"Geriatric care assessment: a coordinated plan beyond a screening score","words":1161,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which components and follow-up arrangements improve outcomes in a particular community?","How can assessment recommendations become timely accessible care?","Which outcomes matter most to an individual older person?","How do cancer-specific findings transfer to other illnesses, settings and levels of frailty?"]},{"article_id":"pregnancy-sleep","title":"Sleep during pregnancy: changing comfort, side sleeping, insomnia and specific disorders","words":1162,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which symptoms require diagnosis-specific assessment for an individual?","How do treatment effects vary with clinical history, trimester and access?","How can late-pregnancy sleep-position precautions be communicated without anxiety or blame?","What are the longer-term maternal and infant outcomes of tailored sleep-disorder treatment?"]},{"article_id":"sleep-with-newborn-care","title":"Sleep with newborn care: interruptions, shared support and persistent insomnia","words":1193,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which practical support is feasible for a particular family and feeding arrangement?","How can services distinguish insufficient opportunity from insomnia while preserving needed infant care?","Which interventions improve function for caregivers underrepresented in current trials?","How can safe overnight feeding plans account for fatigue, space and available help?"]},{"article_id":"eating-with-practical-constraints","title":"Eating with practical constraints: time, kitchen access, storage and familiar foods","words":1043,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which adjustments are usable and acceptable in an individual’s actual kitchen?","Which adaptations improve nutrition or independence in adequately controlled outcome studies?","How do transport, housing, equipment and food preferences interact with practical support?","How should support be tailored when intake, medical needs or capacity change?"]},{"article_id":"hydration-older-adults","title":"Hydration in older adults: low intake, clinical assessment, access to drinks, heat and individualized fluid needs","words":1107,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which support improves health and wellbeing beyond measured intake?","How can clinical assessment detect low-intake dehydration without relying on one sign?","How do existing restrictions, preferences, swallowing needs and access barriers alter the care plan?"]},{"article_id":"pregnancy-lactation-hydration","title":"Hydration during pregnancy and lactation: total water, drinks, heat, milk-supply evidence and supervised clinical care","words":1150,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which measures of intake and hydration meaningfully guide care in each stage?","Do interventions improve maternal or infant outcomes rather than a surrogate alone?","How should illness, heat,restricted fluids or feeding concerns change the individual clinical plan?"]},{"article_id":"thirst-and-planned-drinking","title":"Thirst and planned drinking: everyday water balance, exercise comparisons, heat-work guidance and overdrinking risk","words":1061,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which drinking approach fits the actual population, activity and clinical constraints?","Which comparisons address performance and which address health outcomes?","How can fluid access be planned while avoiding both inadequate intake and forced overdrinking?"]},{"article_id":"exercise-progression","title":"Exercise progression: load, volume, frequency, recovery and goal-specific evidence","words":1022,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do progression strategies perform over longer periods and outside supervised trials?","How should goals, recovery and access constraints be measured together?","Which approaches reduce injury across different activities without imposing unsupported fixed rules?"]},{"article_id":"exercise-adherence","title":"Exercise adherence: practical constraints, support, monitoring and trial limits","words":1051,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can support improve uptake among people poorly represented among volunteers or gym members?","Which components cause durable changes once support or incentives end?","How can delivery fidelity, practical constraints and meaningful activity outcomes be measured together?"]},{"article_id":"breakfast-and-skipping-breakfast","title":"Breakfast and skipping breakfast: definitions, food quality, trials and population limits","words":1196,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do breakfast composition and total intake shape longer-term effects?","How can trials include different sleep/work schedules and clinical populations?","Which school delivery models improve access and nutrition while avoiding unintended additional intake?"]},{"article_id":"late-night-eating","title":"Late-night eating: clock time, sleep timing, controlled trials and shift-work limits","words":1137,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.12","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do short-term timing mechanisms translate into long-term clinically meaningful outcomes?","Which arrangements are feasible and safe across different shifts and clinical populations?","How can studies separate timing, total intake, food quality, sleep and implementation effects?"]},{"article_id":"magnesium","title":"Magnesium: nutrient functions, foods, blood tests, preparations, deficiency, excess and supplement evidence","words":1711,"questions":11,"references":15,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which preparations improve patient-important outcomes in deficient versus magnesium-replete populations?","How should differing laboratory compartments and uncertain markers guide individualized assessment?"]},{"article_id":"biotin","title":"Biotin: vitamin functions, foods, deficiency, inherited disorders, hair claims, uncertain benefits and laboratory safety","words":1105,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which hair-loss populations with confirmed deficiency benefit on objective outcomes?","Which biomarkers have sufficiently validated clinical interpretation outside experimental depletion?"]},{"article_id":"manganese","title":"Manganese: essential trace-mineral functions, food sources, uncertain supplement benefits, status testing and excess exposure","words":1144,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which exposure biomarkers have validated individual clinical interpretation?","How should long-term total dietary risk and vulnerable-population uncertainty be characterized?"]},{"article_id":"diapers","title":"Diapers: cloth and disposable systems, materials, moisture and evidence limits","words":1115,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do current designs compare in independently funded, well-reported longer trials?","Which skin outcomes matter most across different care routines and populations?","How do environmental estimates change with contemporary products, energy and laundry access?"]},{"article_id":"pacifiers","title":"Pacifiers: design, feeding, sleep, age and dental evidence","words":1288,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do benefits and harms differ by infant feeding needs, age and sustained duration?","Which design features change meaningful outcomes in independently replicated comparisons?","How can sleep guidance be evaluated while distinguishing association from randomized evidence?"]},{"article_id":"food-container-materials-and-reuse","title":"Food-container materials and reuse: intended use, heat, cleaning and migration evidence","words":1012,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do standardized tests compare with current real-use exposures across repeated cleaning and storage?","Which migrants need improved identification, intake data and toxicological characterization?","How can reusable systems combine food safety, material durability and environmental outcomes?"]},{"article_id":"compostable-packaging","title":"Compostable packaging: labels, processing conditions, chemical migration and evidence limits","words":1092,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do certified materials perform across different home climates and actual commercial processing cycles?","What migrates into real foods during intended use, aging and reuse, and how does this contribute to total dietary exposure?","What complete breakdown products and compost residues remain, and what life-cycle comparisons apply to a defined packaging use?"]},{"article_id":"bcaas-and-eaas","title":"BCAAs and EAAs: amino-acid categories, synthesis, soreness and longer-term outcomes","words":1116,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["When does a supplement add meaningful benefit to an already adequate diet and training plan?","Which outcomes and populations benefit over months rather than laboratory hours?","How do preparation, background protein and comparators affect interpretation?","What long-term safety and effectiveness data exist for the actual product?"]},{"article_id":"gaba-supplements","title":"GABA supplements: oral preparations, brain access and mixed sleep or stress findings","words":1165,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Does the actual oral preparation produce a meaningful benefit beyond placebo for the intended outcome?","What are sustained effects and safety in broader clinical populations?","How much ingested GABA reaches human brain tissue, and which peripheral mechanisms matter?","How do subjective, objective and functional outcomes differ across preparations?"]},{"article_id":"digestive-enzyme-supplements","title":"Digestive enzyme supplements: targeted uses, blends and pancreatic replacement","words":1193,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.13","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent qualified clinical review is pending.","No systematic synthesis, independent formal evidence grade or exhaustive product comparison was completed.","Long-term clinical outcomes, uncommon harms, exact formulation comparisons and use in populations excluded from trials remain uncertain.","Full 2023 dyspepsia and 2026 metabolic reports were not directly accessible; their use is limited to inspected original abstracts and disclosures."]},{"article_id":"gene-therapies","title":"Gene therapies: addition, editing, delivery, disease-specific evidence and follow-up","words":1139,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which durable outcomes matter most to patients for each intervention?","How do late risks and repeat-treatment possibilities vary by platform?","How will long-term care, access and evidence gaps change for particular populations?"]},{"article_id":"car-t-cell-therapy","title":"CAR-T cell therapy: engineered immune cells, selected cancer comparisons and safety follow-up","words":1194,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which outcomes remain durable with longer follow-up in each disease and treatment line?","How do manufacturing delays and care access influence outcomes outside trials?","How should rare late harms be quantified for specific populations and products?"]},{"article_id":"stem-cell-and-bone-marrow-transplantation","title":"Stem-cell and bone-marrow transplantation: cells, donors, recovery and outcomes","words":1191,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Qualified clinical, lived-experience and methods review remains pending; no formal evidence grade or automatic updates.","No exhaustive transplantation guideline, disease-by-disease treatment recommendation or individual eligibility assessment was completed.","Current regimens, alternative donors, longer follow-up and patient-specific risk may differ from the selected trial comparisons.","Several original full clinical reports were inaccessible; use is bounded to inspected original methods/results abstracts, indexed passages and explicitly related investigator/network summaries."]},{"article_id":"bleeding-disorders","title":"Bleeding disorders: platelets, clotting factors, von Willebrand disease, inherited and acquired causes, tests and care","words":1164,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which assessment and prevention approaches best address uncommon acquired or platelet-function disorders?","How should low-certainty treatment recommendations be individualized across procedures and life stages?"]},{"article_id":"sickle-cell-disease","title":"Sickle cell disease: hemoglobin subtypes, trait, acute complications, prevention, pain care and treatment evidence","words":1120,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How durable are cell-therapy benefits and risks across ages, genotypes and broader clinical settings?","Which patient-important chronic-pain approaches have robust comparative evidence?"]},{"article_id":"thalassemia","title":"Thalassemia: alpha and beta forms, trait, transfusion dependence, iron overload, testing and evolving treatment evidence","words":1166,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What long-term comparative effects and rare harms emerge after cell therapies?","How should clinical categories and organ-specific monitoring be individualized across different globin forms?"]},{"article_id":"cystic-fibrosis","title":"Cystic fibrosis: CFTR function, diagnosis, multisystem care and treatment evidence","words":1159,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do genotype-specific benefits and safety change over longer follow-up and in underrepresented populations?","Which ongoing therapies remain useful in different modulator-treated clinical contexts?","How can care reduce treatment burden while preserving function, safety and access?"]},{"article_id":"down-syndrome","title":"Down syndrome: chromosome types, individual development, lifelong health care and evidence gaps","words":1125,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can comparative adult care studies reflect meaningful function, participation and individual preferences?","Which screening and treatment approaches improve important outcomes in different co-occurring conditions?","How can transition and accessible care improve while condition-specific evidence remains limited?"]},{"article_id":"surgery-and-anesthesia","title":"Surgery and anesthesia: care phases, sensation and sedation, outcomes and safety evidence","words":999,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do technique comparisons differ across procedures, baseline health and recovery outcomes?","Which safety-system components and implementation practices cause durable improvements?","How can risk discussions reflect uncertainty and individual goals without universal technique rankings?"]},{"article_id":"organ-transplantation","title":"Organ transplantation: organ types, donor pathways, continuing care and outcome evidence","words":1166,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.14","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can survival, participation, quality of life and treatment burden be compared across current organ-specific pathways?","How do estimates change with candidate selection, graft loss and longer follow-up?","How can equitable access and donor assessment improve without turning population averages into individual promises?"]},{"article_id":"social-determinants-of-health","title":"Social determinants of health: structural conditions, causal questions and policy evaluations","words":1322,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which structural interventions produce sustained health gains and for whom?","How do resources, service quality and implementation change intervention effects?","How can assistance respect people’s priorities while measuring whether needs were actually met?"]},{"article_id":"community-prevention-and-public-health","title":"Community prevention and public health: programmes, policies, implementation and outcomes","words":1178,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How will the proposed programme reach people who face access barriers?","Which benefits, burdens and unintended consequences should be measured locally?","Can delivery be sustained and evaluated as populations and services change?"]},{"article_id":"health-equity","title":"Health equity: fairness, need, access and measurable differences","words":1172,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Qualified clinical, public-health, methods and lived-experience review remains pending; no formal evidence grade or automatic updating.","No exhaustive health-equity intervention synthesis, complete causal explanation of every disparity or individual risk prediction was completed.","Targeted-population benefits do not by themselves establish narrowing of between-population gaps; implementation, sustainability and who is reached need evaluation.","Some full original intervention and algorithm reports were unavailable; relevant claims are bounded to inspected original abstracts, indexed passages and recorded access limits."]},{"article_id":"healthcare-access-and-costs","title":"Healthcare access and costs: eligibility, available services, affordability and outcome evidence","words":1335,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which financing changes improve meaningful health and financial outcomes across current service settings?","How can programme designs address remaining geographic, quality and practical barriers after direct fees change?","How can evaluations distinguish service use from outcomes while respecting population and policy differences?"]},{"article_id":"public-health-surveillance","title":"Public health surveillance: collection methods, signals, changing ascertainment and evidence limits","words":1185,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can surveillance improvements demonstrate useful action and meaningful health effects rather than report volume alone?","How do reporting, sampling and diagnostic changes alter trends across underrepresented populations?","How can timely data use protect rights, trust and the communities represented?"]},{"article_id":"screening-programs-and-policy","title":"Screening programmes and policy: invitation, complete pathways, benefits and harms","words":1168,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do newer risk-stratified pathways change benefits, harms and participation compared with older invitation trials?","How can programme evaluation capture access, diagnostic completion, treatment capacity and informed choice as well as testing volume?","When should new evidence change introduction, modification or cessation decisions in a particular jurisdiction?"]},{"article_id":"occupational-health-hazards","title":"Occupational health hazards: exposure, risk assessment, prevention, worker participation and health surveillance","words":1093,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How well do feasible controls reduce exposure and patient-important outcomes in specific sectors?","Which participation and enforcement approaches protect precarious workers without shifting responsibility onto them?"]},{"article_id":"workplace-infection-prevention","title":"Workplace infection prevention: transmission routes, cleaner air, vaccination, sick leave, task-specific PPE and exposure response","words":1134,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which feasible combinations reduce infections in specific workplaces and transmission conditions?","How do paid leave, staffing, access to vaccination and equipment use affect prevention in practice?"]},{"article_id":"occupational-noise-and-hearing","title":"Occupational noise and hearing: exposure measurement, ototoxic chemicals, prevention, hearing checks and evidence limits","words":1106,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which engineering and organizational controls prevent long-term hearing loss under real work conditions?","How durable are fit-training benefits, including consistent use and combined chemical exposures?"]},{"article_id":"workplace-dust-and-respirators","title":"Workplace dust and respirators: dust types, source control, filters, fit testing, medical evaluation and equipment limits","words":1186,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.15","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How do engineering controls and sustained equipment use reduce disease across specific tasks?","How does fit change across models, wearers and work conditions, and how well does measured fit predict actual protection?"]},{"article_id":"systematic-reviews-and-meta-analysis","title":"Systematic reviews and meta-analysis: review purposes, pooling, overlap and interpretation","words":1155,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How well do available reviews answer the exact population, comparison and outcome of interest?","Which original studies and cohorts overlap across reviews and follow-up reports?","How do synthesis choices and critical methodological weaknesses change interpretation of the apparent average?"]},{"article_id":"bias-in-health-research","title":"Bias in health research: selection, measurement, missing results and uncertain direction","words":1248,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which specific mechanism could distort this outcome and analysis, and in which direction under plausible assumptions?","Does apparently missing information reflect poor reporting, flawed conduct or both?","How do tool-version changes and uncertain empirical averages affect a transparent result-specific judgment?"]},{"article_id":"certainty-and-uncertainty","title":"Certainty and uncertainty: confidence intervals, meaningful effects and evidence appraisal","words":958,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which uncertainty comes from sampling, model assumptions, study bias, indirectness or missing evidence?","What range of effects remains compatible with the data relative to a justified practical threshold?","Which communication methods improve understanding and decisions, as distinct from short-term trust measures?"]},{"article_id":"conflicting-health-guidelines","title":"Conflicting health guidelines: compare questions, evidence, values, versions and settings","words":997,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Do the apparently competing recommendations actually address the same population, action, outcome and setting?","Which differences reflect evidence selection, certainty judgments, values, resources or outdated versions?","What further matched appraisal and qualified clinical interpretation are needed before applying guidance to a particular decision?"]},{"article_id":"health-misinformation-and-influencers","title":"Health misinformation and influencers: claim accuracy, uncertainty, credentials, incentives and communication evidence","words":1076,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which communication approaches improve verified health behavior across different audiences without widening access barriers?","How well do brief accuracy prompts and transparent disclosures work across present-day platforms and repeated exposure?"]},{"article_id":"conflicts-of-interest-and-research-integrity","title":"Conflicts of interest and research integrity: financial and other interests, disclosure, management and evidence appraisal","words":1194,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which management safeguards preserve independent analysis and reporting across different funding arrangements?","How do transparent disclosures affect real clinical decisions rather than hypothetical appraisal alone?"]},{"article_id":"retractions-and-source-updates","title":"Retractions and source updates: corrections, expressions of concern, versions, provenance and evidence reassessment","words":1177,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How reliably does status metadata propagate across saved copies, indexing platforms and evidence syntheses?","When does removal of a particular study materially change a synthesis or clinical recommendation?"]},{"article_id":"study-designs","title":"Study designs: descriptive, observational, experimental and predictive questions","words":1897,"questions":13,"references":16,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which design and comparison actually produced this claim?","Does the inference concern prediction, description or changing an outcome?","What alternatives and setting differences remain despite a transparent report?"]},{"article_id":"causation-and-confounding","title":"Causation and confounding: assumptions, selection and competing explanations","words":1324,"questions":9,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which exposure versions and population define the causal claim?","What selection or unmeasured causes could change the estimate?","Would another plausible causal structure produce the observed association?"]},{"article_id":"randomized-trials","title":"Randomized trials: assignment, analysis targets and application to care","words":1387,"questions":10,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.16","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which clinical effect and analysis population were prespecified?","What follow-up or adherence assumptions affect interpretation?","How do the trial’s care setting, comparator and outcomes relate to the decision?"]},{"article_id":"cell-cultured-foods","title":"Cell-cultured foods and cultivated meat","words":924,"questions":6,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.17","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term comparative health outcomes and product-specific nutritional, environmental and allergen conclusions require their own evidence. Authorization and availability can change by jurisdiction."]},{"article_id":"natural-and-artificial-flavors","title":"Natural and artificial flavors: what is actually different?","words":919,"questions":7,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.17","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Ingredient lists generally do not give flavor-mixture concentrations; a label alone cannot establish individual dose or risk."]},{"article_id":"skin-absorption","title":"Skin absorption: what gets through, what stays in skin, and why dose matters","words":825,"questions":5,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.17","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Absorption measurements cannot provide one universal percentage or determine every person’s long-term outcome for every formulation."]},{"article_id":"everyday-emfs","title":"Everyday EMFs: electric cars, Wi-Fi and health","words":1216,"questions":8,"references":13,"depth_status":{"status":"expanded_explainer","edition":"explainer-series","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Direct long-term disease estimates for a particular Tesla model or bedside router are not established by the selected measurement studies.","The animal synthesis has a correction and competing interpretations; neither underlying dataset has been independently reanalysed by Atlas.","A complete current regulatory audit and qualified clinical or medical-physics review have not been completed."]},{"article_id":"understanding-lab-results","title":"Understanding abnormal laboratory results","words":935,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How should a change be interpreted when a laboratory changes assay methods?","Which comparison population and decision framework apply to a particular patient?"]},{"article_id":"menopausal-hormone-therapy","title":"Menopausal hormone therapy: systemic, local and bioidentical explained","words":924,"questions":6,"references":12,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Absolute benefits and harms by specific preparation, route, age and clinical history.","Independent reconciliation of divergent timing and mortality interpretations.","Comparative long-term outcomes for currently marketed compounded preparations."]},{"article_id":"medical-report-language","title":"Positive, negative and unremarkable: medical report language","words":898,"questions":6,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How consistently do reporting services use uncertainty terms across specialties?","Which test-specific follow-up resolves an indeterminate result without unnecessary procedures?"]},{"article_id":"hba1c","title":"HbA1c versus blood sugar: different measurements, different timescales","words":969,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which marker best reflects glucose exposure when red-cell survival is altered?","How should persistent discordance be evaluated with a particular assay and clinical context?"]},{"article_id":"compounded-medicines","title":"Compounded, generic and brand-name medicines","words":1101,"questions":7,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Country-specific substitution and compounding rules beyond the selected US examples","Comparative outcomes and batch-quality evidence for individual compounded preparations","Subsequent FDA policy, litigation or shortage-list changes"]},{"article_id":"aqi-meaning","title":"Air Quality Index and PM2.5","words":996,"questions":6,"references":9,"depth_status":{"status":"expanded_explainer","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent medical review and a comprehensive literature synthesis remain unfinished.","The best index design for pollutant mixtures, rapid changes and individual susceptibility remains under study.","No local live air-quality feed or personalized exercise threshold is provided."]},{"article_id":"adaptogens","title":"Adaptogens: plants, stress-support claims, traditional use and clinical evidence","words":1028,"questions":6,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which standardized preparations produce reproducible meaningful benefits in which populations?","Long-term effects, interactions and the evidence for multi-plant combinations remain incompletely established."]},{"article_id":"pre-workout-supplements","title":"Pre-workout supplements: ingredients, tingling, pumps, performance and uncertainty","words":1059,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which finished formulas add meaningful benefits beyond simpler ingredient comparisons?","Long-term effects and use in underrepresented populations or with medical conditions remain incompletely established."]},{"article_id":"vo2-max-watch","title":"VO2 max: oxygen use, watch estimates, laboratory testing and health-risk interpretation","words":1049,"questions":6,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How well do current algorithms track within-person change across diverse clinical and demographic groups?","The practical consequences of score-driven behavior and updated software need separate evidence."]},{"article_id":"statistical-significance","title":"Statistical significance and clinical meaning","words":1272,"questions":8,"references":12,"depth_status":{"status":"expanded_explainer","edition":"4.18","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How different decision frameworks change conclusions for a specific clinical question","Population- and outcome-specific meaningful-change thresholds","Bayesian intervals, equivalence and noninferiority methods beyond this introduction"]},{"article_id":"copper-water-bottles","title":"Copper water bottles: what leaches, what the evidence shows, and what to check","words":963,"questions":6,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.20","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent product-specific migration tests across water chemistry, lining condition, cleaning, temperature and repeat use.","Clinical outcomes of ordinary bottle use and evidence for claimed digestion or immune benefits.","Specialist appraisal for infants, liver disease and inherited copper-handling disorders; no personal copper allowance is supplied."]},{"article_id":"remineralization-and-trace-mineral-drops","title":"Remineralization and trace mineral drops: what are you adding back?","words":888,"questions":7,"references":10,"depth_status":{"status":"expanded_explainer","edition":"water-claims-expansion","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent trials of specified commercial drops on meaningful clinical outcomes, rather than composition alone.","Long-term effects of changing water mineral contributions in populations with inadequate total intake.","Product-specific finished-water mineral amounts and contaminant testing after the added stage."]},{"article_id":"oxygenated-water","title":"Oxygenated water: what does extra oxygen in a drink actually do?","words":975,"questions":7,"references":10,"depth_status":{"status":"expanded_explainer","edition":"water-claims-expansion","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent replication of specified nanobubble formulations with preregistered clinically meaningful outcomes.","Reliable measurement of consumed oxygen exposure and any physiologically meaningful intestinal absorption.","Long-term safety and effects in populations poorly represented in the small trials."]},{"article_id":"structured-and-crystal-water","title":"Structured and crystal water: what vortex devices, gemstones and shungite actually change","words":1049,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"pending","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Whether a particular marketed device produces a reproducible, lasting change in the finished drinking water under ordinary use.","Whether a defined product improves meaningful human outcomes in well-controlled studies.","The composition and leaching behavior of any particular loose-stone or shungite batch; this guide did not test products."]},{"article_id":"colloidal-silver","title":"Colloidal silver: particles, promises and actual medical uses","words":872,"questions":8,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.20","independent_expert_review":false,"authored_body_words":872},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which specifically characterized formulation, route and indication is being tested?","What longer-term controlled human evidence could resolve safety and clinical-benefit questions?","No oral dosing schedule, self-treatment plan or qualified medical signoff is supplied."]},{"article_id":"raw-water","title":"Raw water: what untreated spring water leaves unanswered","words":950,"questions":8,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.20","independent_expert_review":false,"authored_body_words":950},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What are the measured contaminants, collection practices and current conditions at the exact source?","Which treatment and monitoring requirements apply in the relevant jurisdiction?","This is not a universal household treatment recipe, current local advisory feed or personalized water plan."]},{"article_id":"cast-iron-cookware","title":"Cast iron cookware: seasoning, iron transfer and the limits of anemia claims","words":905,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent migration tests that quantify real seasoning condition, enamel wear and the foods actually eaten.","Well-controlled trials separating food iron, absorbed iron and clinical outcomes while accounting for adherence, infection and baseline iron status.","Qualified appraisal of cookware decisions in iron-overload disorders without imposing unsupported blanket dietary restrictions."]},{"article_id":"aluminum-cookware","title":"Aluminum cookware: surfaces, food migration and what health evidence can tell us","words":897,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent, representative product testing that separates anodization quality, additional coatings, wear and food matrix.","Better estimates of household cookware contributions to total and absorbed aluminum, including people with impaired kidney function.","Clinical outcomes from ordinary cookware use and representative prevalence of lead-contaminated products, beyond selected samples."]},{"article_id":"grilling-and-charring","title":"Grilling and charring: cooking chemicals, human evidence and practical checks","words":853,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How much exposure reduction ordinary households achieve across different foods, grills and recipes.","Whether particular cooking modifications reduce clinical cancer outcomes, rather than only measured compounds.","Better repeated exposure measurements and independent replication of specific human associations."]},{"article_id":"antinutrients","title":"Antinutrients: different compounds, absorption studies and the whole diet","words":852,"questions":7,"references":10,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How specific preparation changes affect nutrient status across complete diets over longer periods.","Which populations show meaningful adaptation to habitual phytate intake and by what mechanisms.","More clinical-outcome evidence separating individual compounds from the overall dietary pattern."]},{"article_id":"homeopathic-products","title":"Homeopathic products: dilution, evidence, labels and replacement risks","words":878,"questions":8,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which well-conducted trials would resolve the low-certainty signals for specific conditions?","How often do current products differ from their labeled composition?"]},{"article_id":"oil-pulling","title":"Oil pulling: what plaque studies show, what they do not, and practical limits","words":878,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Do adequately powered, independently replicated trials show fewer cavities or lasting gum benefits?","How do specific oils and commercial blends compare using the same clinical endpoints and follow-up?"]},{"article_id":"antioxidants-and-oxidative-stress","title":"Antioxidants and oxidative stress: what the chemistry does—and does not—tell you","words":945,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which specific tissue measurements predict clinically meaningful changes in a given disease?","How do formulation, baseline nutrient status and dose change benefit and harm?","Independent qualified appraisal of ingredient-specific uses and interactions."]},{"article_id":"resting-heart-rate","title":"Resting heart rate: counting a pulse, interpreting a trend and knowing its limits","words":863,"questions":7,"references":9,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent validation of current devices and their specific resting-rate summary algorithms across ages, skin tones, illnesses and medicines.","Which home pulse-monitoring schedules improve meaningful outcomes in defined populations; no universal schedule or optimal pulse target is established here."]},{"article_id":"nosebleeds","title":"Nosebleeds: first aid, recurring bleeding and treatment evidence","words":863,"questions":7,"references":8,"depth_status":{"status":"expanded_explainer","edition":"4.21","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which moisturizing or antiseptic products benefit particular recurrent-nosebleed populations, and how current formulations compare.","How differing topical tranexamic-acid protocols perform across comparable emergency settings; this guide has not repeated a systematic review."]},{"article_id":"private-wells","title":"Private wells: testing, interpreting results and treatment follow-up","words":1049,"questions":14,"references":10,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":661},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The household’s actual water, well construction and local contamination conditions have not been assessed.","Local sampling, construction and treatment requirements need current place-specific advice.","Full appraisal of newer representative private-well surveys and clinical outcomes remains incomplete."]},{"article_id":"headaches","title":"Headaches: patterns, causes, diaries and assessment","words":1222,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"batch1_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Complete subtype-specific treatment comparisons and current absolute benefit–harm estimates.","How diary-assisted care and different reassurance approaches affect long-term outcomes in diverse populations."]},{"article_id":"food-recalls-and-illness-reporting","title":"Food recalls and illness reporting: identifying products, following notices and preserving useful information","words":1162,"questions":14,"references":12,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":756},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["This page does not provide a live recall feed or verify an individual package.","Current product notices, national reporting routes and public-health instructions may change.","The effectiveness of different alert designs and the completeness of consumer reporting have not been systematically reviewed here."]},{"article_id":"diarrhea","title":"Diarrhea: short episodes, persistent changes and getting help","words":1082,"questions":11,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch1_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current pathogen-specific treatment choices and local testing availability require separate appraisal.","Adult strain-specific probiotic benefit and patient-important outcomes remain uncertain."]},{"article_id":"sleep-paralysis","title":"Sleep paralysis: sleep transitions, frightening experiences, recurrence and assessment","words":1133,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"first-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current, adequately powered randomized trials for recurrent isolated sleep paralysis.","Long-term treatment benefit, harms and applicability across age and clinical groups.","Which assessment and support best reduces fear, sleep avoidance and daytime burden?"]},{"article_id":"meal-replacements","title":"Meal replacements and nutrition drinks: partial meals, complete diets and clinical support","words":1033,"questions":13,"references":9,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":683,"authored_faq_answer_words":314},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No current brand comparison or product-specific nutritional assessment is supplied.","Current national programme eligibility, duration rules and individual medicine plans require accessible current guidance and clinical advice.","Long-term comparative outcomes, maintenance strategies and formulation-specific safety require broader appraisal; the final five-year DiRECT paper was not retrieved in this pass."]},{"article_id":"muscle-cramps","title":"Muscle cramps: nighttime and exercise patterns, causes, treatment evidence and assessment","words":1399,"questions":14,"references":14,"depth_status":{"status":"expanded_explainer","edition":"first-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which prevention strategies improve symptoms, sleep and function in specific cramp populations?","Independent replication of longer-duration magnesium findings and formulation comparisons.","Better standardized outcomes and harms reporting, including pregnancy, neurological disease and exercise settings."]},{"article_id":"infant-crying-and-colic","title":"Infant crying and colic: expected patterns, illness clues, feeding checks, safe coping and remedy evidence","words":1273,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"4.11","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which safe interventions improve caregiver wellbeing as well as crying in diverse families?","Which probiotic strains have reproducible benefits in particular feeding groups, and how do current products compare with studied preparations?","How well do real-world crying-support programmes prevent injury rather than change knowledge alone?"]},{"article_id":"swallowing-problems","title":"Swallowing problems: dysphagia, assessment and everyday decisions","words":1285,"questions":13,"references":12,"depth_status":{"status":"expanded_explainer","edition":"batch1_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Cause-specific treatment effectiveness and comparative instrumental-test outcomes need separate appraisal.","Effects of texture strategies on pneumonia, hydration, nutrition, adherence and quality of life in diverse populations remain uncertain."]},{"article_id":"nightmares-and-night-terrors","title":"Nightmares and night terrors: recall, responses, assessment and treatment evidence","words":1188,"questions":14,"references":12,"depth_status":{"status":"expanded_explainer","edition":"batch-1-draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical review and a comprehensive search are not completed.","Comparative harms, access, long-term durability and underrepresented populations need fuller review.","This guide does not diagnose an event or provide personal medicine, awakening or trauma-treatment instructions."]},{"article_id":"sous-vide-and-vacuum-sealed-foods","title":"Sous vide and vacuum-sealed foods: cooking, cooling and package limits","words":808,"questions":13,"references":6,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":397},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which consumer methods have independently validated heat-up and chilling performance across typical household equipment?","How should current packaging instructions be translated into method-specific consumer choices?"]},{"article_id":"wild-mushrooms-and-foraging","title":"Wild mushrooms and foraging: identification limits, preparation hazards and poisoning","words":1046,"questions":14,"references":9,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":697,"authored_faq_answer_words":333},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No specimen, photograph, app output or home processing method is assessed or approved here.","Species-specific preparation evidence and regional identification resources require dedicated appraisal.","Surveillance reports cannot establish individual poisoning probabilities; current commercial-product recalls require checking the actual notice.","Original app-comparison papers were identified but complete methods were not retrieved; no accuracy percentages are used."]},{"article_id":"seafood-toxins-and-shellfish","title":"Seafood toxins and shellfish: harvest advisories, cooking limits and illness clues","words":930,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":473},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can surveillance better capture unrecognized single-person illness and noncommercial harvest exposure?","Which toxin-specific diagnostic methods become widely available and independently validated?"]},{"article_id":"sleep-debt-and-recovery","title":"Sleep debt and recovery: short nights, catch-up sleep, different recovery measures and practical limits","words":1123,"questions":12,"references":11,"depth_status":{"status":"expanded_explainer","edition":"second-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Feasible, longer-term recovery strategies and clinical outcomes outside tightly controlled laboratories.","How individual needs, age, disease and differing outcomes alter recovery.","Which consumer estimates of accumulated loss have been validated against meaningful recovery outcomes?"]},{"article_id":"drowsy-driving","title":"Drowsy driving: warning signs, prevention and the limits of countermeasures","words":1115,"questions":13,"references":11,"depth_status":{"status":"expanded_explainer","edition":"batch-2-draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical and transport-safety review are not completed.","Long-term crash outcomes, device generalizability and underrepresented driver groups need fuller appraisal.","This guide does not provide individual driving clearance, a timed caffeine/nap protocol or a universal licensing standard."]},{"article_id":"health-anxiety","title":"Health anxiety: illness worries, checking and reassurance, medical assessment and treatment evidence","words":1170,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","edition":"second-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Treatment matching and longer-term functioning, not only questionnaire-score reduction.","Harms, treatment access and outcomes in children, older adults and people underrepresented in trials.","How best to coordinate necessary medical follow-up with treatment of excessive checking and reassurance seeking."]},{"article_id":"blood-in-urine","title":"Blood in urine: visible bleeding, microscopic findings and assessment","words":1047,"questions":11,"references":11,"depth_status":{"status":"expanded_explainer","edition":"batch2_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How current risk-based algorithms and validated markers affect missed diagnoses and long-term patient outcomes.","Cause-specific treatment and follow-up after a negative evaluation need separate appraisal."]},{"article_id":"rectal-bleeding","title":"Rectal bleeding: appearance, urgency, tests and follow-up","words":949,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"batch2_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current pathway implementation, persistent symptoms after negative investigation and long-term patient outcomes.","Cause-specific bleeding treatment and individual antithrombotic decisions need separate clinical assessment."]},{"article_id":"fecal-incontinence","title":"Fecal incontinence: bowel leakage, assessment and treatment choices","words":1093,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch2_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative long-term benefits, device revisions and outcomes in populations underrepresented in trials.","Individualized neurogenic and pediatric bowel pathways need separate research."]},{"article_id":"vaginal-discharge","title":"Vaginal discharge: ordinary variation, changing symptoms, assessment and urgent contexts","words":1098,"questions":12,"references":11,"depth_status":{"status":"expanded_explainer","edition":"batch2_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How should self-sampling and newer diagnostic panels be compared across diverse symptomatic populations and healthcare settings?","Persistent unexplained discharge needs cause-specific specialist assessment beyond this selected-source overview."]},{"article_id":"asbestos-in-homes","title":"Asbestos in homes: suspected materials, renovation and exposure questions","words":888,"questions":14,"references":8,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":503},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["How can an assessor characterize an undocumented past disturbance when no contemporaneous air measurements exist?","What management and disposal requirements apply to this building and jurisdiction?"]},{"article_id":"floodwater-and-home-cleanup","title":"Floodwater and home cleanup: safe entry, contaminated belongings and recovery decisions","words":931,"questions":14,"references":7,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":529},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which hazards and contaminants were present in this specific flood and building?","What inspections, disposal rules, assistance and housing arrangements apply locally?"]},{"article_id":"bedbugs","title":"Bedbugs: confirming an infestation, containing belongings and checking control","words":1001,"questions":14,"references":8,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":657,"authored_faq_answer_words":327},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which affordable monitoring and treatment programs work best across different shared-housing settings?","Which symptom treatments improve patient-important outcomes in clinical trials?"]},{"article_id":"rem-sleep-behavior-disorder","title":"REM sleep behavior disorder: dream enactment, safer nights and assessment","words":1121,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch-3-draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent clinical and neurological review and an exhaustive updated search are not completed.","Long-term injury prevention, comparative treatment harms and applicability beyond older male samples need fuller appraisal.","This guide does not diagnose recorded behavior or prescribe a medicine, supplement dose or personal follow-up schedule."]},{"article_id":"detraining-and-return-to-exercise","title":"Detraining and returning to exercise: what changes during a break","words":1058,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"third-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Maintenance and retraining studies in broader ages, disabilities and everyday unsupervised settings.","How different outcomes recover after medically necessary inactivity rather than a voluntary training break.","Which practical return strategies reduce injuries without rigid universal percentage rules."]},{"article_id":"hoarding-disorder","title":"Hoarding disorder: difficulty discarding, safer homes and treatment","words":1301,"questions":14,"references":10,"depth_status":{"status":"expanded_explainer","edition":"third-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term home function and safety after different treatment programmes.","Treatment access and outcomes for people with limited insight, children and populations poorly represented in trials.","Controlled medication evidence and clearer comparisons of specific therapy components."]},{"article_id":"abnormal-menstrual-bleeding","title":"Abnormal menstrual bleeding: patterns, heavy periods, testing and treatment choices","words":974,"questions":10,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch3_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Cause-specific treatment, pregnancy/postpartum bleeding and detailed postmenopausal investigation belong to separate clinical pathways.","This targeted review does not compare every device, medicine, procedure or fertility outcome."]},{"article_id":"pain-during-sex","title":"Pain during sex: patterns, assessment, comfort and treatment evidence","words":1216,"questions":12,"references":12,"depth_status":{"status":"expanded_explainer","edition":"batch3_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Comparative long-term treatment benefits, harms and access across diverse anatomies, gender histories, ages and pain mechanisms remain incompletely covered.","Penile structural disorders, painful orgasm, post-treatment cancer care and cause-specific pelvic disease need separate clinical pathways."]},{"article_id":"delirium","title":"Delirium: sudden changes in attention, quiet symptoms, care and recovery","words":945,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"batch3_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["The guide does not establish a home diagnosis,drug regimen or intensive-care treatment protocol.","Pediatric delirium tools,withdrawal syndromes and end-of-life management require separate context."]},{"article_id":"anaphylaxis","title":"Anaphylaxis: recognizing danger, emergency plans and follow-up","words":1037,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch3_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No age/weight dose chart,ampoule preparation,intravenous algorithm or individualized prescribing is provided.","The guide does not independently compare every rescue product,immunotherapy or longer-term recurrence-prevention strategy."]},{"article_id":"smoke-alarms-and-home-fire-escape","title":"Smoke alarms and home fire escape: detection, maintenance and a workable plan","words":919,"questions":12,"references":8,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":569},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which detection, installation and maintenance requirements apply to this home?","What assistance and building-specific evacuation arrangements are needed for every occupant?"]},{"article_id":"lithium-ion-battery-safety","title":"Lithium-ion battery safety: charging, damage, compatibility and disposal","words":828,"questions":12,"references":6,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":505},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Is this exact charger, pack and device combination authorized by its manufacturer?","What local service accepts this battery in its current condition?"]},{"article_id":"portable-space-heaters","title":"Portable space heaters: placement, power, fuel and overnight use","words":784,"questions":12,"references":7,"depth_status":{"status":"expanded_explainer","independent_expert_review":false,"authored_body_words":475},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["What clearance, electrical supply and permitted setting does this exact model require?","What suitable heating arrangement is available when people are asleep or unable to supervise?"]},{"article_id":"psychosis","title":"Psychosis: symptoms, assessment and care after a first episode","words":1293,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","edition":"fourth-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Which accessible early-care components best sustain everyday recovery after specialist programmes end.","Better stratified prevention trials and care outcomes beyond transition to psychosis.","How medical, affective and substance-related presentations differ from selected schizophrenia-spectrum trial populations."]},{"article_id":"schizophrenia","title":"Schizophrenia: symptom patterns, diagnosis and ongoing support","words":1230,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","edition":"fourth-milestone-batch","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Long-term comparative benefits and harms beyond the relatively short maintenance trials.","Which practical rehabilitation approaches improve direct everyday outcomes in varied service settings.","Better treatment evidence for persistent negative and cognitive symptoms and populations underrepresented in trials."]},{"article_id":"dissociative-disorders","title":"Dissociative disorders: detachment, memory, identity and pathways to care","words":1061,"questions":13,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch-4-draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Independent qualified psychiatric review and an exhaustive updated search are not completed.","Comparative treatment effectiveness, durability, harms and evidence for dissociative amnesia remain incompletely assessed.","This guide does not diagnose a person, verify a historical event, prescribe medication or provide a trauma-memory recovery procedure."]},{"article_id":"severe-bleeding-first-aid","title":"Severe bleeding first aid: recognition, direct pressure and trained bleeding control","words":892,"questions":10,"references":8,"depth_status":{"status":"expanded_explainer","edition":"batch4_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No tactical-rescue protocol,improvised tourniquet construction or unsupervised wound-packing procedure is supplied.","Clinical-effectiveness evidence and simulation teaching results do not establish identical effects on survival."]},{"article_id":"dental-injuries-and-emergencies","title":"Dental injuries and emergencies: knocked-out teeth, fractures, swelling and urgent care","words":1064,"questions":12,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch4_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No home splinting,root-canal procedure,antibiotic prescription or individualized painkiller regimen is supplied.","Published recommendations do not guarantee tooth survival;late complications and follow-up vary."]},{"article_id":"eye-injuries-and-splashes","title":"Eye injuries and splashes: flushing, foreign objects, assessment and recovery","words":950,"questions":10,"references":9,"depth_status":{"status":"expanded_explainer","edition":"batch4_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["No do-it-yourself object extraction,ocular pH testing,drug regimen or open-globe procedure is provided.","Chemical burns,large abrasions,contact-lens infection and combined injuries need individual assessment beyond simple-scratch trial populations."]},{"article_id":"home-and-long-term-care","title":"Home and long-term care: services, settings, assessment, funding and quality","words":1211,"questions":11,"references":10,"depth_status":{"status":"expanded_explainer","edition":"batch4_draft","independent_expert_review":false},"traceable_passages":true,"expert_review_completed":false,"systematic_synthesis_completed":false,"remaining_questions":["Current comparative outcomes, staffing adequacy, affordability and continuity across service models and jurisdictions require more specific evidence and local assessment.","Insurance appeals, detailed means tests, employment law and housing contracts need current service-specific advice; no personal entitlement or financial determination is provided."]},{"article_id":"cinnamon-supplements","title":"Cinnamon supplements: product identity, glucose findings and safety 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